Cancer Immunotherapy
Re-Engineered

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:
Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another day at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

If you are interested in being a part of a growing Manufacturing Sciences team, then this role may be for you! As a Scientist/Engineer, Manfacturing Sciences, you will report to the Manufacturing Sciences lead, within the Bioprocess Development and Manfuacturing Sciences team. With responsibilities spanning our multi-virus platform, key duties as they relate to this role will include:

• Batch Analysis, data analysis, data mining, data trending, and preparing the data for presentation to management
• Master Batch Record review, and field copy review
• Support the process development team through Drug Substance process scale up, and intensification for GMP manufacturing
• Participate in the development of a novel tech transfer strategy that can demonstrate success if/when travel is limited (COVID-19 restrictions)
• Lead the tech transfer of complex biologic processes between our external CDMO network spanning Canada, the United States, and Europe
• Lead engineering run campaigns at our external CMO network in preparation for GMP manufacturing
• Act as technical lead for investigation of process deviations and technical excursions
• Support drafting and reviewing of regulatory documentation
• Perform risk assessments across a variety of process, manufacturing, and equipment challenges
• Participate in equipment selection, procurement, and qualification processes
• Represent the Manufacturing Sciences team at Technical Operations cross-functional program meetings

What’s in it for you?
In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience & Qualifications:

Qualifications:

Turnstone Tech Ops is a virtual organization, where all of our wetbench work is executed third party CMO/CRO partners. We have offices in Ottawa, Canada and New York, USA – but considering the nature of our work and the global climate, this position can be stationed virtually – ideally within the Eastern time zone. This role is best suited for someone with the following:
• 5-7 years of overall experience within the biotech/pharmaceutical industry
• Bachelors degree in Science / Engineering, with a Master’s or PhD considered an asset.
• Trained in one of the following fields: chemical engineering, biology, biochemistry, or virology
• Basic knowledge of cell biology, and virology
• Experience working with biologic processes (viruses) considered an asset
• Experience with aseptic manufacturing processes (non-terminally sterilized drug substance) considered an asset
• Excellent computer skills, including Microsoft Excel and Powerpoint
• Excellent data analysis capabilities including statistical methods. Experience with statistical software, e.g. JMP, SAS, considered an asset
• Enjoy data mining, trending, and graphing data for presentation within reports or at meetings
• Excellent written communication skills to enable drafting of reports and risk assessments
• Previous experience drafting or reviewing Batch Records considered an asset
• Knowledge of GMPs considered an asset
• Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency, and function effectively in a fast-paced and dynamic environment

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:
Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another day at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

This position is a 6 month contract with the opportunity for renewal, pending the assessment of project outcomes, resource allocations, and mutual assessment of it.

Responsibilities include:
• Perform technical review of analytical data for completeness, accuracy, and GxP compliance in a timely manner to support critical timelines for delivering investigational drug to clinical trials
• Support the execution of new launches, processes and procedures, perform multi-batch trend analysis and compile study documentation
• Work with Quality Control colleagues, vendors, and cross functional teams to support investigations and projects
• Perform Raw material review and assessment for compliance with compendial requirements and specifications.
• Stays up to date on new SOPs, procedures, and techniques via training sessions, team meetings, and internal communication avenues
• Supports designing and implementation of Quality control projects to comply with GxP, regulatory, and Turnstone policies.
• Support management of inventory for QC reference standards, cell banks, and GxP materials

What’s in it for you?
In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience & Qualifications:

Qualifications:

• 2+ years of hands-on experience in the lab performing and data review of methods such as:
o virological and cellular assays (tissue culture, plaque assay, etc)
o molecular assays (qPCR, PCR, ELISAs, Western blot, etc)
o Compendial methods (Sterility, Endotoxin, Mycoplasma, adventitious agents etc)
• Education: diploma or degree in microbiology, biochemistry, biotechnology, or relevant field
• 2+ years experience in Quality control performing product release testing and review
• Knowledge in biological drugs such a viral vaccines, gene therapy, and cell therapies an asset
• Experience using Microsoft applications (Excel, Word, PowerPoint)
• Experience with analytical software such as JMP would be an asset
• Must have knowledge of GMP regulations
• Good organizational and time management skills
• Demonstrated attention to details
• Excellent communication and able to work with different teams

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:
Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another day at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

Responsibilities include: working as part of a team at Turnstone’s Ottawa lab, running established complex analytics to support product characterization, preclinical study sample testing, and analytical development.

What’s in it for you?
In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience & Qualifications:

Qualifications:

This role is best suited for an analyst early in their career, looking for a development opportunity, and with the following experience:
• 2+ years of hands-on experience in the lab (school lab experience counts) performing several methods such as:
o virological and cellular assays (tissue culture, plaque assay, killing assay, TCID50, infections, etc)
o molecular assays (qPCR, PCR, Bradford, ELISAs, Western blot, etc)
• Education: diploma or degree in biochemistry, biotechnology, or relevant field
• Agile in a lab setting, able to quickly learn established methods
• Experience following a procedure several times to generate precise and accurate results
• Careful and diligent method execution and reporting
• Organized and able to manage time to enable the execution of several experiments at once when required
• Very comfortable using Microsoft applications (Excel, Word, PowerPoint). Experience with analytical software such as JMP would be an asset.

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:
Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another day at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

In this role, you will have the opportunity to lead a team of dedicated and high-performing scientists to direct the development and qualification of analytical assays for release and characterization testing of our platform technologies of novel biotherapeutics, from live virus products to synthetic peptide vaccines. This team also heavily supports analytics for preclinical animal studies. Current products are in early clinical development and so many assays are at the starting line of their analytical life cycle management. This is an opportunity to establish rigorous and far reaching processes for assay qualification and validation, with an eye to Phase 3 and beyond. This role will necessitate partnering very closely with many other teams within Technical Operations (Bioprocess Engineering, Manufacturing Sciences, Quality Control, Analytical Operations, Quality Assurance), Regulatory Affairs, and Research (preclinical studies) to generate assays that are relevant and cutting edge. The associate director of analytical development will also be involved at times in meetings with external parties in support of regulatory interactions, diligence meetings, business partnerships, etc. This role will have elements of technical oversight, helping the team strategize and investigate technical problems, and operational oversight, ensuring that resources are used wisely and the team is supported in their efforts.

We are looking for a scientist that enjoys working as a team and growing as a leader, someone that believes that WHAT we do and HOW we do it are both critical to success. We are looking for a leader that can prioritize a heavy workload where resources are always limiting, supporting higher level discussions around regulatory implications and employee career development, as well as someone that is willing to roll up their sleeves and pitch in on the ground floor when required. You’ll have experience working with some or all the following, as they relate to analytical development:

Priority areas of interest:
• Biophysical and analytical chemical methods that support particle measurements, virus particle state assessment, and protein profiling with special attention to HPLC-based methods. Understanding of other related methods such as LC-MS, DLS, zetasizer, nanosight, FFF-MALS, etc are considered an asset.
• In depth knowledge of the methods, instruments, and regulatory considerations of next generation sequencing and it’s use in GMP environments considered an asset
• Experience developing qPCR methods for GMP an asset

Secondary areas of interest (already well supported within the team, but further asset in understanding critical methods): Cellular and molecular methods such as virus titering by plaque assay, genome quantitation by qPCR, impurity assessment by ELISA or qPCR, etc.
• Developing analytics for biological product characterization and release, experience with live virus products an asset
• Engaging in discussions with colleagues on their analytical needs, assessing/investigating various technologies to support those needs, and making decisions on technologies to pursue
• Supporting Quality Control scientists in their suspect results investigations to ascertain root cause and path forward
• Developing methods to support GMP product characterization or release and supporting the method life cycle management
• Developing methods to support preclinical studies to interrogate virus or protein levels in animal tissues – GLP knowledge an asset
• Performing or managing assay qualification and validation according to principles in ICH Q2, especially as is appropriate to support early clinical development
• Working closely with external CROs and vendors to drive projects to completion in a timely and scientifically sound manner
• Act as subject matter expert in analytical development during diligence and regulatory interactions
• Experience working within GMP quality systems is a must (change control, deviations, corrective and preventive actions, document control)

What’s in it for you?
In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience & Qualifications:

Qualifications:

This role is best suited for a scientist with 8+ years experience in directly leading analytical method development and qualification of complex biologics in support of GMP clinical product release, leading complex projects, and supporting regulatory submissions. Candidates for this roles will have directly coached and supervised a team of analytical scientists for at least 5 years and worked with external vendors to achieve a project goal. Candidates have likely achieved either a Masters or PhD in a relevant scientific discipline and are looking to use their knowledge in a meaningful and impactful way, while also learning about new methods, products, and processes. Candidates with less formal academic training may also be considered, but having more deep, diverse, and extensive experience will be crucial. Learning agility is critical as the methods leveraged by the Turnstone CMC analytics team are extremely broad and cutting edge. Candidates have demonstrated the ability to manage both small and large projects, multi-tasking effectively, and having an external presence that is professional, collaborative, and influential.

Travel during the COVID-19 pandemic is highly restricted and unlikely to be necessary. However, upon resumption of regular office life, you will need to travel on occasion to our various vendors (global) and also visit our Ottawa and NYC offices often to stay connected, productive, and excited. This role will report to the Director of Analytical Development and Quality Control at Turnstone. Based on a mutual discussion of fit, the successful candidate(s) will reside at either the Ottawa or New York office location, though special consideration will be given to anyone living in eastern North America who is able to travel on occasion (post COVID-19).

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.