Leading the Fight

Against Solid Tumors

Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.

At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.

Position overview:

We are seeking an enthusiastic and driven Scientist with a strong background in immunology and genomics to join our team of immunologists driving the development of Selected-TIL therapies for the treatment of cancer. The successful candidate will deploy functional genomics, single cell sequencing and cellular immunology to support preclinical programs advancing our TIL platform. In this role, you will have the opportunity to develop your ability to think strategically, drive fast-paced execution, and collaborate with team members across the research department.

The Responsibilities include but are not limited to the following:

• Contribute to target evaluation and validation for select TIL improvement using in vitro assays such as cytotoxicity, expansion, and cytokine secretion.
• Genetically engineer immune cell populations and screen for novel targets.
• Contribute to product characterization and target identification using gene expression profiles, genome annotation, TCR sequencing and single cell RNA sequencing data.
• Independently design, execute, analyze, and troubleshoot experiments to support preclinical discovery in discovery in immunology therapeutic areas.
• Communicate and collaborate effectively with colleagues to drive progression of the project.

Experience:

• Ph.D. with a strong background in Immunology and bioinformatics or computational biology.
• Experience with current NGS platforms including single-cell analysis algorithms.
• Advanced immunology laboratory skills, with demonstrated proficiency in multi-parameter flow cytometry biochemical, immunological and cell biology techniques.
• Proficiency in R or Python is highly preferred.
• Prior experience in analyzing and integrating TCR-seq or CITE-seq datasets is preferred.
• Experience with genetically engineering primary immune cells using CRISPR-based approaches is preferred.
• Experience with guide-seq, circle-seq or site-seq is a plus.
• Excellent written and oral communication skills, including an ability to explain complex ideas to other team members.
• Strong interpersonal skills and a communication style that matches the Turnstone style: respectful, transparent, and constant.

 The anticipated salary range for this role is $100,000 – $125,000.

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.

At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

We are seeking a passionate and driven Research Technician/Associate to join our team of immunologists driving the development of Selected-TIL therapies for the treatment of cancer. The successful candidate will provide support and assistance to senior researchers at our San Diego site using state-of-the-art instrumentation and following established laboratory standard operating procedures (SOPs).  In this role, you will have the opportunity to develop your ability to think strategically, drive fast-paced execution, and collaborate with team members across the research department.

The Responsibilities include but are not limited to the following:

• Molecular editing of immune cell populations and rapid expansion.
• Validation of editing using PCR and western blot or flow cytometry.
• Assessment of TIL phenotype using flow cytometry.
• Isolation of tumor and immune cells from patient samples.
• Assessment of TIL functionality using in vitro assays to measure cytotoxicity, expansion, and cytokine secretion.
• Support other team members by preparing reagents and materials.
• Generate quality data and study summary reports in a timely manner.
• Contribute to a team-centric culture that values transparency, innovation, integrity, and purpose.

Experience:

• B.S in Biology with previous experience in immunology is required.
• Must have experience with immune cell culture with excellent sterile technique.
• Experience with multi-parameter flow cytometry is preferred.
• Experience with lentiviral and/or CRISPR-CAS9 techniques for editing and engineering immune cells is a plus.
• Experience with DNA isolation, PCR, and western blot analysis is a plus.
• Experience with tumor digestion and cell sorting is a plus.
• Strong work ethic, positive team-oriented attitude is a must.

The anticipated salary range for this role is $70,000 – $85,000.

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.

At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:
Turnstone is seeking a Research Associate to join our team of immunologists driving the development of TIL therapies for the treatment of cancer. This successful candidate will drive various aspects of in vitro by designing and executing experiments, analyzing data and presenting results in a collaborative team setting. This is an exciting opportunity to work alongside senior researchers and project teams to perform discovery and development research that will ultimately create new medicines for cancer patients at our state of the art facilities in San Diego. We have an open, transparent and dynamic culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.

The Responsibilities include but are not limited to the following:

• Perform isolation, expansion and phenotyping of various immune cell populations (T cells, DCs and B cells) for use in immunologic assays.
• Design, execute and analyze in vitro studies to assess TIL expansion, phenotype and functionality.
• Assessment of TIL phenotype using flow cytometry (from simple to complex panels, including spectral cytometry)
• Assessment of TIL functionality using in vitro assays to measure cytotoxicity, expansion, and cytokine secretion.
• Generate quality data and study summary reports in a timely manner.
• Prepare data/figures to present to senior research staff.
• Contribute to a team-centric culture that values transparency, innovation, integrity, and purpose.

 Preferred Experience:

• B.S or M.S in Biology with previous experience in immunology.
• Extensive experience with mammalian cell culture with excellent sterile technique.
• Experience with multi-parameter flow cytometry.
• Experience with Immune cell culture and functional assays.
• Experience with cell sorting is a plus.
• Strong work ethic, attention to details and positive team-oriented attitude is a must.

The anticipated salary range for this role is $70,000 – $85,000.

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.

At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

Turnstone’s T cell therapy technology is based on a Selected-TIL process that revolutionizes the generation of tumor targeted T cells for adoptive cell therapy. We are looking for a passionate and driven team player with experience in molecular biology, cell culture, flow cytometry and immunologic assays to help develop these next gen T cell products for preclinical and clinical evaluation. You will work alongside senior researchers at our Ottawa research facility (located at Carleton University), designing and executing cell-based immunology studies following established standard operating procedures (SOPs). In this role, you will have the opportunity to develop your ability to think strategically, drive fast-paced execution and collaborate with team members across the research department.

 Responsibilities include but are not limited to the following:

• Design, execute and analyze in vitro studies to assess TIL expansion, phenotype and functionality.
• Co-culture of TIL and tumor cells for assessment of T cell reactivity by cytokine secretion, proliferation and cell killing.
• Generate quality data and study summary reports in a timely manner.
• Communicate findings to senior research staff.
• Contribute to a team-centric culture that embraces scientific excellence, collaboration, innovation, integrity and hard-work.

 Requirements:

• Scientific degree with Immunology experience is required.
• Multi-parameter flow cytometry experience is required.
• Must have experience with mammalian cell culture, experience with immune cell culture is preferred.
• Strong work ethic with a positive team-oriented attitude.
• Ability to effectively multi-task and adapt in a fast-paced environment.

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.

At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.

Job Summary

The Director, Clinical Data Management & Biostatistics will take the data management lead on outsourced Phase I/II/III studies. Since the studies are outsourced, the individual will provide vendor management oversight including biostatistics services and strategic biostatistics consultants as well as review of DMPs, CRFs, DVS, perform UAT, etc. The individual must be an experienced Data Manager who is able to work independently and cross functionally. This individual must be self-motivated and collaborative amongst internal stakeholders as well as external and CRO partners as appropriate.

Responsibilities

• Responsible for assessing in house data management needs and driving the selection and implementation of any in-house data management solutions including developing policies and procedures
• Responsible for clinical data management activities for outsourced studies
• Ensures data management activities for clinical trials within assigned research program(s) are completed in a timely and accurate manner
• Leads statistical and programming vendors to plan and implement statistical and programming project plans
• Develops proposal requests to service providers; evaluates and approves service level agreements
• Oversees service providers to perform core data management functions including IWR/IVRS, CRF, edit check and CRF completion guidelines development, user acceptance testing, data cleaning, reviewing listings, and database locking procedures
• Works collaboratively with Biostatistics and Programming during data integration leading up to a regulatory filing
• Establish inter- and intradepartmental processes to improve the efficiency and quality of data processing
• Leads and manages DM tasks outsourced to external vendors and ensures that milestones, deliverables, quality and timelines are met within budget and in accordance with regulatory requirements.
• Develops positive partnerships with CROs and ensure a high standard of deliverables are maintained.
• Serves as the DM focal point on assigned studies for all local interfaces and preserves a fluent workflow with the other interfacing departments and local procedures and processes.
• Prepares and maintains timelines for the assigned studies and communicates to management any issues so that appropriate actions can be taken.
• Prepares status reports and updates for data management as required
• Collects and monitors study metrics
• Plans and oversees preparation of safety committee data management as well as annual report data management Approves data management plans for completeness and accuracy of required documentation
• Oversees, review of the DMP and other pertinent documents for all assigned studies.
• Oversees and performs UAT on CDMS components as needed.
• Provides input into CDMS requirements, assuring protocol requirements are met.
• Supports validation efforts to minimize the company’s exposure to regulatory risk by validating all electronic data streams and systems in support of organizational objectives

Skills, Qualifications, And Requirements

• BS Life Sciences or Computer Science
• 8-10 years of data management experience in a clinical research setting
• Strong working knowledge and prior experience directly managing/overseeing service providers and CRO’s is required
• Prior experience managing clinical data for multiple studies at one time
• Experience with computerized clinical data management systems is required
• Knowledge of SAS and database programming
• Systems integration experience
• Understanding of CDASH and CDISC standards
• Ability to work independently and collaboratively in a fast-paced, matrixed team environment consisting of internal and external team members
• Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines

The anticipated salary range for this role is $175,000 – $210,000

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.

At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.

Job Summary

Reporting to the Vice President, Clinical Development, the Director, Clinical Science will be a key contributor to Turnstone’s clinical development programs. The Director is supporting the planning and execution of clinical studies in a timely manner, in adherence with GCP, appropriate SOP’s and government regulations. He / She also conducts ongoing medical/safety data reviews, plans and supports study reporting and acts as a primary point-of-contact for site specific clinical questions.

Responsibilities

• Under the direction and oversight of the VP, Clinical Development, design, oversee and/or execute, as needed and as appropriate, key clinical deliverables including document development necessary for study design, activation, conduct and reporting (protocols, ICFs, IBs, CRFs, SAPs, Clinical study reports (CSRs).
• Assume a lead role in clinical study data review and interpretation and contribute to the development of deliverables required for ongoing study data review process.
• Work closely with individuals in other functional areas (e.g., clinical operations, project and program management, safety and pharmacovigilance, regulatory affairs and quality, pre-clinical and research, manufacturing, finance, contract resources, vendors etc.) in the creation, management, and execution of the clinical development plans, in developing innovative and efficient solutions to medical and scientific clinical trial issues, and ensuring the successful execution and completion of Turnstone’s clinical trials.
• Contribute content to regulatory submissions (INDs, NDAs, MAA etc.) as well as to documents to support Regulatory Authority interactions (briefing books, response documents etc.).
• Provide medical and scientific input and generate content for abstracts, posters, presentations and manuscripts.
• Contribute medical and scientific input into the Clinical Development Plans for preclinical and early-stage clinical assets.
• Identify risks, develop risk mitigation plans, and escalate risk mitigation strategies as appropriate.
• Contribute to and optimize an effective KOL and investigator communication strategy, interacting with investigators as warranted to obtain necessary information before, during and after the study.
• Working with other departments, create functional policies and procedures to provide strong and efficient clinical development processes that are appropriate for a matrixed environment.
• Ensure that relevant SOPs are current and complete.
• Assess, recommend, track functional budgetary and staffing needs for medical/clinical aspects of clinical trials
• May also assist with other broad or diverse activities as needed, and when appropriate, including Clinical Development activities (e.g., contributing to the development of an IND for a preclinical asset, etc), Business Development activities (e.g., contributing to Search and Evaluation efforts, Diligence, etc), or other non-clinical departmental activities.
• Other related duties as assigned.

Qualifications

• Advanced degree such as PhD, Pharm D, MD or equivalent is preferred and +5 years directly related experience in a clinical development-biopharmaceutical environment, or the equivalent combination of education and experience.
• Demonstrated skills and understanding in Phase 1-3 clinical trial design and data interpretation; experience with oncology clinical trials is required.
• Knowledge of applicable FDA Code of Federal Regulations, Good Clinical Practices (GCP), ICH Guidelines, is required.
• Familiarity with the drug approval process through NDA or BLA or ex-US drug approval process is preferred.
• Sufficient content expertise and prior experience to be able to be a key contributor to document development such as INDs, Protocols, ICFs, IBs and regulatory submission package (NDA/MAA), under the direction and oversight of the VP, Clinical Development.
• Sufficient scientific knowledge and prior experience to play a lead role in the process of clinical study data review and interpretation.
• Proven track record of successfully delivering projects on time, to budget and the required quality.
• Excellent interpersonal, verbal and written communication skills.
• Team player, with the ability to move in a fast paced and dynamic environment.
• Ability to build and maintain effective internal and external professional relationships.
• Ability to travel approximately 25% of the time.

 The anticipated salary range for this role is $160,000 – $200,000

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.