Driving The Power of Innate and Adaptive Tumor Immunity
About Us
Turnstone Biologics’ mission is to deliver breakthrough cancer immunotherapies by advancing two leading and complementary platforms targeting tumor immunity, to improve survival for people with cancer.
Turnstone Biologics is a privately-held clinical stage biotech company with offices in New York City (USA), San Diego (USA) and Ottawa (Canada). Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity plus local expression of encoded therapeutics, while the TIL cell therapy platform leverages clinically validated protocols to add industry-leading cell selection strategies. Our development programs drive innate and adaptive tumor immunity to provide benefit to the millions of cancer patients underserved by current treatment options.
Our scientific founders, Drs. John Bell, David Stojdl and Brian Lichty, are world leaders in the oncology and immunotherapy fields. Collectively, they have authored more than 200 publications in leading journals, and have spent years engineering and developing technologies to create the next generation of powerful, targeted therapies for cancer patients.
Our passionate team of leaders in oncology have decades of experience in biotechnology, academia and pharmaceutical drug development. With comprehensive capabilities in immuno-oncology discovery, basic research, translation, clinical development, manufacturing, and commercialization, we are committed to bringing new medicines to people with cancer to improve their lives.
Our Science
Turnstone Biologics is focused on driving innate and adaptive tumor immunity through the development of two independent, yet complementary platforms, built on a foundation of validated clinical success.
Turnstone’s proprietary vaccinia virus platform has been engineered to stimulate the immune system, drive antigen presentation and recognition, and re-shape the tumor microenvironment. The high degree of tumor selectivity and large transgene capacity of the virus can be utilized to deliver other agents and therapeutics directly to sites of tumors throughout the body for local expression, reducing their potential for systemic toxicity.
There has been strong clinical evidence demonstrating the benefit of TIL therapy in solid tumors, however, driving clinical benefit in harder to treat, lower mutational burden cancer indications, is the next needed innovation in the field. Turnstone’s proprietary TIL platform combines leading methods for identifying relevant tumor reactive T cells from TILs with the latest advancements in cell sorting and cell rejuvenation, enabling rapid advancement of these highly promising enriched T cell therapies to address a broad range of solid tumors.
Pipeline
Turnstone is developing two highly innovative and complementary therapeutic platforms. Our RIVAL pipeline is derived from our viral immunotherapy platform, with the lead RIVAL-01 program in early clinical development. Our TIDAL pipeline is derived from our cell therapy platform, with the lead TIDAL-01 program expected to enter the clinic by early 2022.
Leadership
Turnstone Biologics was founded by world-leading experts in cancer immunotherapies who have defined and advanced the field over the course of multiple decades. Our leadership team includes experts from academia and the life sciences industry who share the vision of bringing innovative immunotherapies based on our unique viral and TIL therapy platforms to people with cancer.
Sammy Farah, PhD, MBA
President & Chief Executive Officer
Dr. Sammy Farah has extensive vaccine expertise and almost 20 years of scientific, business and executive management experience in the biotechnology industry. He joined Turnstone Biologics from Synthetic Genomics Vaccines, Inc., where he served as President. Prior to that, he was Chief Business Officer of Immune Design Corp. And before then, Sammy was at Versant Ventures where he specialized in biotechnology investing and new company formation, and at Merck & Co., Inc. where he led technology support for multiple commercial vaccine franchises before joining the business development and licensing group to evaluate and execute new external technology and research partnerships. Dr. Farah earned an M.B.A. from the Wharton School at the University of Pennsylvania, a Ph.D. in biochemical engineering from Stanford University, and a B.S. in biochemical engineering from the Massachusetts Institute of Technology.
Stewart Abbot, PhD
Chief Scientific Officer
Dr. Abbot has more than 20 years of research and development experience in cell-based products and leads Turnstone’s R&D organization. He joined Turnstone from Adicet Bio where he was Chief Scientific and Chief Operating Officer, responsible for R&D activities for allogeneic gamma delta T cell therapies. Prior to this, Dr Abbot served as Chief Development Officer at Fate Therapeutics and oversaw development of hematopoietic and induced pluripotent stem cell-based immunotherapeutics. His previous roles included Executive Director of Integrative Research and Senior Director of Research at Celgene, where he led technology and cell therapy product scouting, alliance identification and business development activities, initiated engineered T cell programs, and developed novel therapeutic candidates based on hematopoietic stem cells and human placenta-derived cells; and Head of the Molecular and Cellular Biology research group for GE Global Research at General Electric. Dr. Abbot holds a B.Sc. in Biological Sciences from the University of Edinburgh, M.Sc. in Biomedical Engineering from the University of Strathclyde in Glasgow, and Ph.D. in Pathology from the University of London.
Saryah Azmat
Chief Business Officer
Ms. Azmat leads business development, corporate strategy, and capital formation at Turnstone. Her contributions and leadership have been critical to the growth of the business, including Turnstone’s recent acquisition of Myst Therapeutics and ongoing investor relations activities. Ms. Azmat joined Turnstone from Bristol-Myers Squibb (“BMS”), where she was the Global Lead for Oncology Search & Evaluation. During her six-year tenure at BMS, Ms. Azmat executed over 15 major transactions spanning all stages of preclinical and clinical development. Prior to BMS, she was a consultant for global biopharma clients at Putnam Associates, where she managed clinical and commercial stage projects. Ms. Azmat earned a B.A. in engineering sciences and a B.E. in biomedical engineering from the Thayer School of Engineering at Dartmouth College.
Steve Bernstein, MD
Chief Translational Officer
Steven Bernstein, M.D., has more than 20 years of experience as a treating physician, translational scientist and pharmaceutical executive. Prior to joining Turnstone, Dr. Bernstein served as Chair, Immuno-Oncology Translational Research and Development, and Head, Integrated Science, at Bristol-Myers Squibb. Prior to BMS, he was as an academic physician scientist most recently at the University of Rochester’s James P. Wilmot Cancer Institute, where he was Professor of Medicine, Co-Director of the Hematological Malignancy and Lymphoma Biology Programs and Co-PI of the University of Rochester/Arizona Cancer Center NCI SPORE grant in lymphoma. Dr. Bernstein was a member of the Lymphoma Working Group of SWOG, and the Scientific Advisory Boards of both the Lymphoma Research Foundation and the Leukemia and Lymphoma Society.
P. Joseph Campisi, Jr., Esq.
General Counsel
Joseph serves as Senior Vice President and General Counsel, bringing to Turnstone more than 30 years of experience in mergers and acquisitions, collaborations, and securities offerings and corporate governance. Joseph joined Turnstone from Scorpion Therapeutics where he was Executive Vice President, General Counsel and Secretary. Prior to this, Joseph was Senior Vice President and Deputy General Counsel at Bristol-Myers Squibb (“BMS”), where he oversaw the Transactional Practice Group of the BMS Law Department. During more than 16 years at BMS, Joseph was responsible for the completion of over 100 strategic transactions, including the sale of BMS Medical Imaging, the divestiture of the BMS diabetes business, the sale of ConvaTec, and the initial public offering and subsequent split-off of Mead Johnson Nutrition, as well as the acquisitions of Medarex, Inc. and Celgene Corporation. Before BMS, Joseph was a partner at the law firm Pillsbury Winthrop Shaw Pitman LLP, where he was a member of the firm’s Corporate and Securities and Life Sciences practice groups, and spent time in the firm’s offices in New York, London, Hong Kong and San Francisco during his 13-year tenure there. Joseph obtained a Juris Doctor with distinction from Hofstra University School of Law, a Master of Business Administration (Finance), and a Bachelor of Science (Accounting) from St. John’s University. He is admitted to the bar in both the State of New York and the State of California and is licensed in the State of New York as a Certified Public Accountant (inactive).
José Manuel Otero, PhD
Chief Technology Officer
Dr. Otero heads bioprocess development, manufacturing, and CMC at Turnstone, across both viral and cell-based therapies, bringing with him nearly 20 years of industry experience in vaccines and complex biologics. He joined Turnstone from Seres Therapeutics, Inc., where he was Vice President of Bioprocess Development and Manufacturing. Dr. Otero oversaw expansion of the group and was the team leader for the first synthetic microbiome therapy to enter clinical studies in the U.S. Dr. Otero started his career at Merck & Co., Inc., where he was Head of Fermentation Development before becoming a Director of Engineering to support multiple commercial vaccine franchises. He earned a Ph.D. in chemical and biological engineering from Chalmers University of Technology, and an M.Eng. in biomedical engineering and a B.S. in chemical engineering from the Massachusetts Institute of Technology.
David Stojdl, PhD
SVP, Discovery Research
Dr. David Stojdl pioneered the exploration of host-virus interactions critical to oncolytic therapy to guide the clinical development of more effective virus platforms. At the Ottawa Regional Cancer Centre, he first identified VSV as an oncolytic virus and defined the archetypal role of interferon signaling in tumor-specific oncolytic virus targeting. Since joining the CHEO Research Institute in 2004, Dr. Stojdl has discovered and developed several novel oncolytic vector platforms, including the Maraba oncolytic virus platform. Dr. Stojdl also directs the CHEO Automated Screening Centre (CASC), leveraging state-of-the-art high-throughput robotic screening technology to uncover new insights for the clinical development of oncolytic virus biotherapies. Dr. Stojdl is a professor in the Department of Pediatrics and Department of Biochemistry, Microbiology and Immunology at the University of Ottawa. He was a scientific co-founder and consultant to Jennerex Biotherapeutics (later acquired by SillaJen Biotherapeutics). He received a Ph.D. from the University of Ottawa and an M.S. and B.S. in microbiology and immunology from the University of Western Ontario.
TJ Langer
SVP, Cell Therapy Development and External Innovation
TJ Langer is SVP of Cell Therapy Development and External Innovation and brings with him more than 16 years of biopharma product discovery, development and commercialization experience to Turnstone. TJ was the CEO of Myst Therapeutics before it was acquired by Turnstone in 2020, a biotech company he founded which pioneered novel cellular immunotherapies based on tumor infiltrating lymphocytes (TIL) for the treatment of solid tumors. Prior to Myst, TJ was responsible for the development of cell therapy at Kite Pharma and was influential in progressing YESCARTA® from pre-IND through to post-BLA approval. He subsequently led the development of engineered TCR cell therapy targeting patient specific neoantigens following Gilead’s acquisition of Kite. TJ earned a B.E. in Biomedical Engineering from Vanderbilt University.
Maura Campbell, PhD
VP, Intellectual Property & Contracts
Dr. Maura Campbell has spent more than 20 years in technology transfer and the management and commercialization of intellectual property (IP). She has business management experience in all key sectors of biotech, including private and public companies, universities and research institutes, and government-funded public sector research organizations (National Centre of Excellence [NCE]). Maura joined Turnstone Biologics from VBI Vaccines where she served as Director, Intellectual Property. She also was with the Ottawa Hospital Research Institute (OHRI) as a Senior Research Program Manager, where she oversaw the oncolytic vaccine project commercialization. Earlier in her career, Maura was the Director of Intellectual Property for PainCeptor Pharma Corporation, the Manager of Technology Transfer & Commercialization for the OHRI, and the Manager of Technology Transfer at the Institute for Robotics and Intelligent Systems at NCE. She has served as an IP consultant to a number of Canadian start-ups including Neurochem, Conjuchem, Aonix, AMRIC and Sussex Research Labs. Maura received a Ph.D. in biochemistry from the University of Ottawa, and an M.Sc. and a B.Sc. in biochemistry from Queen’s University in Kingston.
Karen Major
VP, Regulatory
Karen Major has 18 years of Regulatory Affairs experience, specializing in the global development of biotechnological oncology products. Prior to joining Turnstone, she was Sr. Director Regulatory Affairs at Arbutus Biopharma, focusing on chronic HBV. Prior to that, she held the same position at Tekmira Pharmaceuticals, developing siRNA-LNP products in oncology, infectious disease and metabolic indications. Karen led the Regulatory Affairs departments at YM BioSciences (acquired by Gilead in 2013) and Viventia Biotechnologies. Karen holds an honors BSc in Pharmacology and Toxicology from the University of Toronto, a post-graduate diploma in Regulatory Affairs and Quality Operations from Seneca College, and a Regulatory Affairs Certification (RAC) from RAPS.
Adina Pelusio
VP, Clinical Operations
Adina Pelusio has more than 15 years of experience in drug development, most recently as the Vice President, Clinical Operations at SillaJen Biotherapeutics (formerly Jennerex, Inc), where she spent a decade advancing oncolytic viruses in clinical trials. In addition to overseeing the Clinical Operations department at SillaJen, she managed and pioneered the medical educator role to expand hospital personnel comfort and knowledge globally with oncolytic viruses. Prior to Jennerex, Ms. Pelusio served as a SWAT Senior Clinical Research Associate at PPD, a large, global CRO, where she was tasked with study rescue and served on a technology committee assigned with developing training for CRAs and project teams on new technologies within the field.
Jerel Davis, PhD
Chairman & Director,
Versant Ventures
Dr. Jerel Davis is a Managing Director at Versant Ventures and is based in Vancouver. Since joining Versant in 2011, he has played a critical role in launching and investing in a number of Versant’s portfolio companies including Quanticel Pharmaceuticals, Crispr Therapeutics, Blueline Bioscience, Northern Biologics and several of the Inception Sciences discovery start-ups. He has also led Versant’s execution of build-to-buy structured acquisitions with Celgene, Roche and Bayer. Over the last few years, Jerel has focused on establishing Versant’s presence in Canada, including the launch of new companies in Vancouver, Toronto and Montreal. Prior to joining Versant, Jerel was Associate Principal at McKinsey and Company where he advised pharmaceutical, biotechnology, medical device and molecular diagnostics companies. He has worked in a number of healthcare markets globally including the United States, Europe, China, Russia and India. Jerel was a post-doctoral researcher at Stanford University and worked in research at Amgen.
Brad Bolzon, PhD
Director,
Versant Ventures
Brad Bolzon, Ph.D., is a Managing Director and Chairman of Versant. He combines 13 years of global pharmaceutical industry experience and a similar tenure as a venture capitalist. Brad is the architect of Versant’s investment strategy. His track record consists of successive outlier returns including Amira (sale), Okairos (sale), Speedel (sale), Quanticel (sale), Novira (sale), Flexion (2014 IPO), Crispr (2016 IPO), BioTie (sale), Jecure (sale), Inception (multiple sales) and BlueRock (sale), and he continues to manage several other promising investments.
Prior to joining Versant, Brad served as Executive Vice President, Global Head of Business Development, Licensing & Alliances at Roche. Under his leadership, Roche established alliances with over 75 venture-backed biotech companies worldwide and transformed its R&D pipeline into an industry leader. Prior to that, Brad held executive roles at Eli Lilly in drug discovery, clinical research, regulatory affairs and business development. He earned Master of Science and Ph.D. degrees in Pharmacology from the University of Toronto.
Mike Burgess, MBChB, PhD
Executive Director,
Turnstone Biologics, SpringWorks Therapeutics
Dr. Mike Burgess brings 20 years of drug research and development experience to Turnstone Biologics. At Bristol-Myers Squibb, he led strategy and execution of translational medicine, early-stage clinical trials and clinical pharmacology across all therapeutic areas, including oncology. Prior to this at Roche, Mike held several different senior leadership positions, including acting global head of Roche Pharma Research and Early Development (pRED) and Senior Vice President and Global Head of Oncology Research and Early Development. Before joining Roche, Mike spent 7 years at Lilly working on early stage oncology trials. Mike received his medical degree (MBChB) and a Ph.D. in molecular biology from the University of Bristol, UK and spent 10 years as a practicing physician in pediatrics and pediatric oncology.
Sammy Farah, PhD, MBA
Director,
Turnstone Biologics
Dr. Sammy Farah has extensive vaccine expertise and almost 20 years of scientific, business and executive management experience in the biotechnology industry. He joined Turnstone Biologics from Synthetic Genomics Vaccines, Inc., where he served as President. Prior to that, he was Chief Business Officer of Immune Design Corp. And before then, Sammy was at Versant Ventures where he specialized in biotechnology investing and new company formation, and at Merck & Co., Inc. where he led technology support for multiple commercial vaccine franchises before joining the business development and licensing group to evaluate and execute new external technology and research partnerships. Dr. Farah earned an M.B.A. from the Wharton School at the University of Pennsylvania, a Ph.D. in biochemical engineering from Stanford University, and a B.S. in biochemical engineering from the Massachusetts Institute of Technology.
Robert Gould
Director,
Fulcrum Therapeutics
Robert Gould joined Fulcrum as president and CEO at the time of the company’s launch in 2016, bringing over 30 years of experience to the role. Previously, he served as president and CEO of Epizyme from 2010 to 2015. Prior to joining Epizyme, Robert served as director of novel therapeutics at the Broad Institute of MIT and Harvard from 2006 to 2010. Robert spent 23 years at Merck where he held a variety of leadership positions, culminating in the role of vice president, licensing and external research. Throughout his time at Merck, Robert was instrumental in advancing more than 20 compounds from discovery into clinical development in multiple therapeutic areas. Robert received a B.A. from Spring Arbor College and a Ph.D. from the University of Iowa and completed postdoctoral studies at the Johns Hopkins University.
Rishi Gupta, JD
Director,
OrbiMed
Rishi Gupta is a private equity partner at OrbiMed. Prior to that, he was a healthcare investment banker at Raymond James & Associates, served as manager of corporate development at Veritas Medicine and was a summer associate at Wachtell, Lipton, Rosen & Katz. Rishi has published scientific articles on the mechanisms of HIV entry into host cells and legal articles on intellectual property laws in the developing world. In addition to Turnstone Biologics, he serves or has served on the boards of Dimension Therapeutics, Symbiomix Therapeutics, Avitide, Verona Pharma, ChemoCentryx and Sientra. He has also been actively involved with OrbiMed’s investments in Acceleron Pharma, CoGenesys, Supernus Pharmaceuticals, Adimab, Receptos, Aragon Pharmaceuticals, Seragon Pharmaceuticals, Alector, Arsanis, Biotie, Invitae and ORIC Pharmaceuticals. Rishi earned a J.D. from the Yale Law School and an A.B. degree magna cum laude in biochemical sciences from Harvard College.
Stefan Larson, PhD
Director,
Sectoral Asset Management
Dr. Larson joined Sectoral in 2018 as Partner – Private Equity, responsible for leading biotechnology private equity investments. Prior to joining Sectoral, Dr. Larson was an Entrepreneur-in-Residence and later Venture Partner with Versant Ventures, where he led the establishment of their Toronto-based Discovery Engine and was the founding CEO of Northern Biologics. Dr. Larson was also a co-founder of two medical device companies: Perimeter Medical Imaging, and Tornado Spectral Systems. He began his career at McKinsey & Company in San Francisco and Toronto. Dr. Larson received his B.Sc. in Biology from McGill University, and his M.Sc. in Molecular and Medical Genetics from the University of Toronto, prior to completing his Ph.D. in Biophysics at Stanford University.
Patrick Machado
Director,
Former CFO/CBO Medivation
Patrick Machado is a co-founder of Medivation, Inc., a biopharmaceutical company, and has served on its Board of Directors since April 2014. Prior to his retirement in April 2014, Mr. Machado served as Medivation’s Chief Financial Officer since its inception in September 2003 and as its Chief Business Officer since December 2009. From 1998 until 2001, Mr. Machado was employed by ProDuct Health, Inc., a privately-held medical device company, as Vice President, Chief Financial Officer and General Counsel from 1998 to 2000, and as Senior Vice President and Chief Financial Officer from 2000 to 2001. From 2001 until 2002, Mr. Machado served as a consultant to Cytyc Corporation, to assist with transitional matters related to Cytyc Corporation’s acquisition of ProDuct Health, Inc. Mr. Machado received a J.D. from Harvard Law School and a B.A. and B.S. in German and Economics, respectively, from Santa Clara University.
Santhosh Palani, PhD
Partner,
PFM Health Sciences
Santhosh is a Partner at PFM Health Sciences, where he invests in private and public biotechnology companies. He has served on the boards of companies in gene editing, cell therapy, and targeted oncology fields. Previously, he was a Principal at New Enterprise Associates (NEA), where he invested in early-stage private companies in the biopharmaceutical sector. Prior to that, he was a Vice President at Cowen and Company in Equity Research, where he covered SMID Cap Biotechnology stocks. He previously served as an Associate Director in oncology clinical development at Pfizer, and as a Scientist in oncology preclinical development at Takeda Pharmaceuticals (Millennium). He earned his PhD in Bioengineering from the University of Pennsylvania and completed his postdoctoral work in Biochemistry and Molecular Biophysics at Columbia University. He is a CFA® Charterholder.
Jeff Courtney
In Memoriam
Jeff Courtney helped to form Turnstone Biologics and was an outstanding leader for FACIT (Fight Against Cancer Innovation Trust). Jeff’s life’s work and warm personality inspires all of us at Turnstone Biologics to drive forward our mission to help cancer patients, and we greatly miss his presence, leadership and friendship.
Partners
We are backed by top-tier life science and biotech investors and are partnered with institutions who are committed to Turnstone’s growth and advancing transformative technologies that meaningfully alter the treatment paradigm of cancer therapy. Since our inception in 2015, we have raised more than $360 million in venture capital and non-dilutive financing and secured partnerships with major biopharmaceutical companies, including a billion-dollar deal with Takeda Pharmaceutical Company Limited.
In December 2019, Turnstone Biologics announced a global collaboration and license agreement with Takeda to develop novel viral immunotherapies from Turnstone’s proprietary vaccinia virus platform for a broad range of cancer indications.
News
Careers
We continue to build a world-class team of specialists as we collaborate to transform cancer care. If you’re a passionate person, and our mission and science excite you, Turnstone Biologics might be for you.
Turnstone Biologics’ team works with a sense of urgency to fulfill our mission. Our decision-making is driven by science and our therapeutics are designed with the patient in mind. We value transparency, innovation, integrity and purpose. Our employees, with their relentless drive and expertise, are the basis of our success.
Team Opportunities
Turnstone Biologics is dedicated to excellence and innovation in every aspect of our science and business. We are actively looking for exceptional individuals who share our passion for developing and delivering next-generation cancer immunotherapies. We offer competitive compensation and benefits and are an equal opportunity employer.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
• Provide first-level support for internal staff and talent resolving laptop (PC and Mac), mobile devices, network issues, software support, account login, and A/V issues
• Communicate effectively with technical and nontechnical users both in person and through Microsoft Teams, email, chat, and our help desk ticketing system, Zendesk
• Provision and deprovision hardware, user accounts, software, and cloud¬-based applications, such as Office 365, Okta, Egnyte, and DocuSign
• Troubleshoot issues effectively – know when to use your resources and when to escalate
• Assist with account management and purchasing of hardware and help maintain inventory levels
• Prioritize and manage help desk tickets and evaluate/execute urgent tasks as needed
• Investigate malware, PUA alerts, and other security-related incidents, along with patching machines/vulnerabilities
• Identify ways to streamline common processes and ensure we maximize value within IT
• Participate in technology program rollouts, such as when new services and applications become available
• Documentation support: participation in the creation of and adherence to documented procedures
Requirements
The ideal candidate should have a college degree or equivalent mix of education, certifications, and experience. They should also have minimum 2–3 years of experience as an IT systems administrator and demonstrate knowledge/skills in most of the following areas:
• Thorough knowledge of Microsoft Office 2016, Office 365, Microsoft Teams, and Windows 10
• Working knowledge of MacOS, AAD, Intune, DNS, DHCP, TCP/IP, LAN/WAN/WiFi
• Knowledge of Crestron AV and meeting space technologies
• Proficiency with mobile devices (iPhone & Android)
• Interested in learning and taking on increasingly complex tasks
• Strong organizational and task management skills
• Able to work independently and within a team environment
• Ability to handle multiple tasks and meeting deadlines while maintaining a strong commitment to quality of work
• Scripting knowledge and an automation mind-set
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
Turnstone is seeking a Research Associate to join our team of immunologists driving the development of our growing pipeline of T cell and oncolytic virus immunotherapies. This is an exciting opportunity to work along side senior researchers and project teams to perform discovery and development research that will ultimately create new medicines for cancer patients.
Turnstone’s T Cell therapy technology is based around a powerful new Selected-TIL process that revolutionizes the generation of tumour targeted T cells for adoptive cell therapy. Your role will be to work with a team of immunologists and molecular biologists to invent and develop these next gen T cell products for preclinical and clinical evaluation. There will be additional opportunities to continually refine the technology and manufacturing processes for this class defining therapy. If you have experience with T cell manipulation, engineering and culture, then this opportunity may be just what you are looking for.
You will work along side senior researchers and supporting technical colleagues within project teams at our state of the art facilities in San Diego and participate in designing and executing cell-based human immunology studies following established laboratory standard operating procedures (SOPs). We have an open, transparent and dynamic culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.
In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!
We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and grow your career right along with the company.
The Responsibilities include the following:
-Drive various aspects of in vitro and in vivo studies including but not limited to: designing and executing experiments, organizing teams, scheduling and managing complex multi-disciplinary experiments including data collection, analysis, and interpretation.
-Prepare data/figures to present to senior research staff
-Generate study reports in a timely manner
-Write and review SOPs
-Contribute to a team-centric culture that embraces scientific excellence, integrity, and urgency
Experience:
-Degree in Immunology/Microbiology/Biochemistry (research primarily focused in immunology) with recent biotech or pharmaceutical industry experience preferred
-Extensive experience with immune assays including flow cytometry, ELISA, ELISPOT, immune cell culture and common molecular techniques.
-Experience with T cell engineering is highly desirable
-Experience studying T cell metabolism and cell state is a plus
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
Turnstone’s T Cell therapy technology is based around an exciting new Selected-TIL process that revolutionizes the generation of tumour targeted T cells for adoptive cell therapy. Your role will be to join a team of immunologists and molecular biologists who invent and develop these next gen T cell products for preclinical and clinical evaluation. There will be additional opportunities to continually refine the technology and manufacturing processes for this class defining therapy. If you have experience with T cell manipulation, engineering and culture then this opportunity may be just what you are looking for.
You will work along side senior researchers and supporting technical colleagues within project teams at our state of the art facilities in San Diego and participate in designing and executing cell-based human immunology studies following established laboratory standard operating procedures (SOPs). We have an open, transparent and dynamic culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.
What’s in it for you?
In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!
We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and grow your career right along with the company.
The Responsibilities include the following:
-Design and execution of in vitro and in vivo studies to understand T cell activity, function, cell state and phenotype from human and rodent tissues
-Participate individually or as part of project teams to schedule and manage complex multi-disciplinary experiments including data collection, analysis, and interpretation.
-Prepare data/figures and presentations to communicate results from experiments to senior research staff
-Generate study reports in a timely manner
-Write and review SOPs and overseeing training for team members
-Contribute to a team-centric culture that embraces scientific excellence, integrity, and urgency
Experience:
-Ph.D. in Immunology/Microbiology/Biochemistry (research primarily focused in immunology) with post graduate experience or and/or biotech or pharmaceutical industry experience
· This role will be positioned out of our new San Diego site
-Deep knowledge and experience in T cell function/differentiation/signaling/regulation, metabolism/phenotypic analysis of inhibitory and costimulatory targets and pathways and/or neoantigen biology and vaccines is highly preferred.
-Robust understanding of innate and adaptive immune systems is required
-An expert knowledge of immune based in vitro assays, flow cytometry and common molecular techniques such as cell based and biochemical assays to interrogate the immunological mileu of human blood tissue or tumour samples, including ICS, ELISpot assay, ELISA, RNA seq
-Experience with T cell engineering highly preferred
-Experience studying T cell metabolism and cell state highly preferred
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
This role will be responsible for elevating the Program Leadership/Project Management and Alliance Management functions to ensure creation of the program plans and budgets, as well as day-to-day planning, coordinating and tracking of critical activities. You will be responsible for providing critical Program/Project Management expertise and support to Turnstone Biologics internal programs and strategic partnerships to ensure all Program / Project milestones and deliverables are met, and that tasks are well managed and executed. You will also be responsible for driving the program timelines to keep them on schedule and within budget. Additional coordination responsibilities, as highlighted in more detail below, also include planning, facilitating, and following-up on regular program team meetings; anticipating and managing potential program issues; understanding the scope, schedule and resources for the program; utilization of Gantt charts and other project management tools to facilitate communication within the team, across the organization, and with external collaborators.
RESPONSIBILITIES
· Oversee internal program leadership, project management and alliance management
· Partner with the Program Leaders, project and alliance managers to optimize team effectiveness and decision making
· Coordinate the management of internal and external programs including project planning, progress tracking and budget planning & tracking
· Interface internally by acting as a liaison and facilitator of cross functional teams (i.e., Clinical Development, Clinical Operations, Technical Operations, Regulatory, Quality Assurance, Finance, etc.) in planning and executing trials
· Champion the development of the Program Leadership Department through introduction of new tools and processes for continuous improvement
· Sets key performance indicators and create timelines for driving internal and external programs on schedule.
· Facilitate highly effective team building and communication
· Proactively and independently, identifies and resolves program team challenges
· Perform effective risk management assessments with the Program Team, the Program Leader, and stakeholders
· Drive information flow and communicates program status to all stakeholders in collaboration with the Program Leaders and Project Managers.
· Coordinate production of regular status reports (milestones, status, issues, decisions), following review by the Program Leader and Program Team, for executive and senior management
· Coordinate portfolio reviews
· Support program knowledge management and data integrity procedures
· Partner with business development to initiate strategic relationships
· Manage and optimize the value of our strategic alliances across research, development and clinical
· Function as the internal and external point of contact for collaboration management and progress
· Support sponsored research contract execution
· Interface externally with collaborators, vendors, contractors, and consultants to ensure communication and deliverables in accordance with planned program objectives
· Identify platform, program and product issues
· Support regulatory filings
· Support setting of program strategy
· Support corporate financing initiatives
· Mentor and develops program leadership & management group members
Experience & Qualifications:
Minimum of a BA/BS is required, while an advanced degree (PharmD, PhD) is highly desirable.
· 10+ years of work experience, 8-10 years of Program/Project or Alliance Management experience, preferably within a matrixed pharmaceutical, biotechnology or medical device organization
· Extensive project planning experience required, especially an understanding of the clinical development and product commercialization processes. PM Certification is a plus
· Oncology experience is highly desirable.
· Advanced (gene or cell) therapy experience is highly desirable.
· Proactive mindset with strong formal and informal leadership, facilitation, teamwork and influence management/negotiation skills.
· Must have excellent verbal and written communication skills as well as exceptional organizational capability.
· Prior experience in leading and managing interdisciplinary or cross functional pharmaceutical or biotech teams is required.
· Ability to drive program plans and timelines (across multiple functional areas) is essential
· Proven success in goal setting, prioritization and time management is required
· Understanding of FDA and/or EMA quality and regulatory processes. Prior experience with regulatory filings is highly desired
· Experience working with external partners is highly desirable
· Experience actively participating in a steering committee or joint development committee for pharmaceutical, biotech, or medical device product development is highly desired
· Ability to work independently in decision-making and resolution of program obstacles and conflicts
· Familiarity with developing budgets and forecasting is desirable
· Keen insight, independent judgment and tactful discretion are required
· Must be able to demonstrate strong analytical and problem-solving capabilities
· Ability to function autonomously, with an appreciation of detail while being cognizant of “the big picture”
· Proficiency with Microsoft Word, Excel, PowerPoint, and Project is required.
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
The Research Technician provides support and assistance to senior researchers and project teams by performing a variety of experimental techniques using state-of-the-art instrumentation, and following established laboratory standard operating procedures (SOPs). The Research Technician is responsible for experimental laboratory duties such as: tissue culture; cell-based functional assays; ELISAs; qRT-PCR; Western blots; immunohistochemistry/immunofluorescence.
The candidate is expected to keep accurate experimental records and contribute to data analysis and figure preparation under supervision of senior research staff.
Additional responsibilities will include inventory management; laboratory organization; routine maintenance and calibration of laboratory equipment.
The incumbent will participate in an innovative research environment and will support a team working to translate basic research findings into novel therapeutic strategies. The position will contribute both intellectually and experimentally to the success of a multidisciplinary team.
Responsibilities:
• Prepare media and solutions
• Tissue culture: maintain primary cells and cell line cultures
• Perform Western and Southern blots
• PCR Analysis
• Assist lab members with various experiments
• Keep accurate experimental records
• Autoclave instruments
• Responsible for following Standardized Operating Protocol for lab tests
• Assist in the summation or analysis of data required for communications/reports/presentations.
• Perform a range of duties associated with maintaining laboratory readiness in cooperation with other team members
• Inventory management, i.e. order/unpack/restock/organize lab supplies as required
• laboratory equipment maintenance and operation
• Other duties as required
Experience & Qualifications:
• Undergraduate degree in science (BSc) or diploma with an acceptable combination of education and experience.
• 2-3 years’ experience in an academic or industrial laboratory preferred
• Must have good analytical and problem solving abilities with strong attention to detail
• Knowledge and experience with standard software (e.g. LIMS, Microsoft Office Suite, GraphPad Prism)
• Knowledge and commitment to Occupational Health and Safety Procedures and Biosafety Procedures in a laboratory.
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
The Director of Program Management will design appropriate program management plans and processes to support clear communication, decision making, prioritization and resource planning. Interact collaboratively with colleagues to ensure alignment on project action items, deliverables, and vision. Responsible for planning and execution of product development projects in the RIVAL portfolio. Plans and directs schedules and monitors budget/spending. Ensures consistent practices throughout all phases of the project life cycle. Drives the development and manages the execution of high quality, integrated cross-functional plans for projects. Applies project management best practices in the development, initiation, planning, execution, control and closing of projects. Provides clear direction on product development requirements to meet expectations of internal and external stakeholders. Interacts with research and development, manufacturing, clinical and regulatory departments and with external stakeholders. Responsible for project performance, risk management, administration, financial management and issue resolution for functional group.
• Ensuring that programs in the Research and Development portfolios are supported with appropriate and consistent Project/Program Management support, including:
o Facilitating the development of cross functional strategy and ensuring appropriate communication to internal stakeholders
o Defining program level plans that include scope, timelines, milestones, deliverables, key Go/NoGo decisions points, resources, and budgets
o Tracking and owning program timeline, milestone, and budget data
o Leading the team through planning for cross functional transitions
o Ensuring that changes to program timelines are appropriately communicated to the team and Leadership
o Coordinating team meetings as needed to meet team deliverables, track decisions and follow up on action items
o Working with the team to identify program risks and develop mitigation strategies
o Partnering with Program Team Leader to drive the team to clear and effective decision points.
• Ensuring that corporate alliances and/or academic collaborations are supported with Alliance management support, including:
o Facilitating joint team meetings at appropriate frequency to meet the needs of the team
o Ensuring internal team and leadership team is aware of and working towards meeting collaboration expectations
o Understanding Turnstone positions on strategic goals and ensuring appropriate communication to partner
o Ensuring team is meeting contractual obligations and flagging to leadership when contractual interpretation is required
• Maintaining close cross-departmental relationships to ensure that all critical parties are aware of project activities, issues and contingencies.
• Proactively, and independently, identifies and resolves program team challenges.
• Preparing information with appropriate input from program team members for internal as well as external partner review/governance meetings
• Developing and implementing communication tools that enhance information exchange within program teams and across functions
• Serving as an integral member of the program management function, ensuring cross-functional alignment of program strategies.
• Driving high performing, cross-functional teams to promote effective communication and ensure integration and alignment of internal subject matter experts via team meetings and program updates
• Performing effective risk management assessments with the Program Team, the Program Leader, and stakeholders
• Reviews and proposes revised program work plans to accommodate changes in technical, marketing, or business objectives
• Providing input along with other senior managers in establishment of strategic plans and objectives. Accountable for making final decisions on administrative or operational matters and ensuring operations effective achievement of objectives.
• Partnering with functional leaders to define project strategies and proactively identify and escalate risks, gaps and challenges, key dependencies and decisions points. Works with teams to develop scenarios and solve problems
• Tailoring program, approach and systems to small and rapidly growing organization.
Experience & Qualifications:
In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth, we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!
We are in the early stages of building strategies, structures and process so this role will be busy and expanding. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.
Requirements:
• MSc or BSc Degree
• 8+ years experience in a project management role in a biotechnology or pharmaceutical company
• PMP Project Management Certificate preferred
• Experience with advanced therapeutics including virus- and cell-based therapies preferred
• Oncology experience is highly desirable
• Familiar with drug development process and a demonstrated understanding of the clinical development process
• Ability to foster business relationships with internal and external business partners.
• Proven ability to influence others to get things done without formal authority.
• Demonstrated ability to map out new business processes and improve existing processes
• Ability to facilitate, negotiate and communicate in cross-functional team environment to achieve overall project goals.
• Self-motivated, comfortable in fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities
• Effective communication, interpersonal skills, collaboration and negotiation skills
• Highly organized and efficient, close attention to details and able to orchestrate multiple projects simultaneously
• Able to represent and communicate project timelines/priorities at senior management meetings
• Proficiency in using Microsoft Office suite – Word, Excel, PowerPoint and Project.
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
This role is part of the Computational Sciences team parting with the Translational Medicine Biomarker team to build and utilize big-data platforms to analyze preclinical, translational, and clinical data. This is a hands-on technical role in which you will aggregate patient clinical data and biomarker data (bulk and single cell NGS and TCRseq, multiplexed flow cytometry, pathology, functional immunology, and proteomic data) to assist in the identification of relevant biomarkers as well as to generate hypotheses that will define and drive the next generation of oncology therapies.
The responsibilities for this role include:
• Manage and evolve global data platforms for clinical and multidimensional correlative data and integrate and analyze such data to understand and define predictive biomarkers, mechanisms of action, mechanism of resistance and disease selection so to drive our optimal clinical development as well as discovery efforts.
• Design and implement computational bioinformatic methodologies to analyze and interpret data from a wide variety of sources including clinical data, external literature, high throughput genomic data, multidimensional pathology data, flow cytometry, functional immune and proteomic data.
• Utilize APIs, data exploration and visualization tools as well as bioinformatics approaches to support discovery, pre-clinical and clinical studies including, but not limited to, informing new disease indications for our therapies, and developing predictive biomarkers
• Collaborate with domain experts in privacy, security, and compliance to ensure that the R&D data platforms uphold privacy, security, and compliance requirements
Experience & Qualifications:
• PhD or Master’s degree in bioinformatics, computer science, statistics, data science or a related field with a particular focus on data analysis.
• This role will be positioned out of either site in San Diego or Ottawa
• Willingness to travel (when it’s safe as it pertains to global pandemics) up to 10-30% to other Turnstone sites and/or external CMOs throughout North America (USA, Canada) and Europe
• First-hand experience using patient clinical and biomarker data (proteomic, flow cytometry, pathology and genomic data-bulk and single cell NGS) in concert with preclinical and public NGS data to develop and support disease selection and biomarker strategies
• 5 years of experience in life sciences, pharma or informatics industry working with clinical trials data, genomics, and biomarker data is preferred.
• 5 years of hands-on experience of applying data science methods and tools to diverse problems using R and/or Python is preferred.
• Expert programmer in at least one language, with experience working in production environments.
• Experience with statistical analysis, bioinformatics/genomics tools (such as GATK, BEDtools, VCFtools, STAR aligner, DEseq, etc.), data visualization, and databases
• Working understanding of innate and adaptive immune systems is preferred
• Experience with data analysis – RNA-Seq, single cell analysis, flow cytometry, variant calling
• Experience with existing and upcoming machine learning methods (supervised and unsupervised) in pharmaceutical data analysis
• Collaborative development skills using version control systems (e.g., Git)
• Familiarity with using virtualized working environments such as Docker
• Proven ability to work in a matrix environment is preferred
• Comfortable in a dynamic environment with competing priorities
• Strong communication both written and spoken
• Strong interpersonal skills and a communication style that matches the Turnstone style: respectful, transparent, and constant
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
This role will build and utilize big-data platforms to analyze preclinical, manufacturing and clinical data. This is a hands-on technical role in which you will aggregate and analyze multiple data types including bulk and single cell genome and transcript sequence data, multiplexed flow cytometry, proteomics, pathology, functional immunology, and manufacturing data. You will help define mechanisms of action, manufacturing optimization strategies and product portfolio development and selection as well as to generate hypotheses that will define and drive the next generation of oncology therapies.
We are in the early stages of building strategies, structures and process so this role will be busy and expanding. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.
The responsibilities of this role include:
• Model and analyze large, complex genomics datasets using machine learning and statistical methods to generate biological insights.
• Support cross-functional collaborations between informatics team and other R&D and GMP manufacturing functions and teams.
• Create and/or operate computational approaches and analytical tools or customize existing applications (as required) to interrogate immune cell quantity, function and phenotype within the tumor microenvironment.
• Investigate the biology of tumor-reactive T cells, nucleic acid in cancer, generate statistically secure findings, and relate them to performance and clinical value of novel gene and cellular therapies.
• Consult within research and cross-functionally to analyze problems, recommend informatics-based solutions, or determine computational strategies.
• Work closely with interdisciplinary teams including research, clinical, product development, laboratory operations, and external collaborators.
• Represent company externally in informatics and industry conferences.
• Stay abreast of industry and academic developments in biological computational science.
• Generate, interpret and communicate knowledge from gene expression profiles, genome annotation, TCR sequencing and single cell RNA sequencing data.
• Manipulate publicly accessible, commercial, or proprietary genomic, proteomic, or post-genomic databases.
• Improve user interfaces to bioinformatics software and databases.
• Instruct others in the selection and use of optimal and appropriate bioinformatics tools
• Review professional literature to maintain professional knowledge.
• Contribute to building a culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.
Requirements
• Ph.D. (or MSc + at least 3 years) in Bioinformatics, Computational Biology, Statistics, Biological Sciences, Cancer Biology, Genetics, Genomics, Computer Science, Physics, or equivalent preparation and experience.
• This role will be positioned out of either site in San Diego or Ottawa
• Willingness to travel (when it’s safe as it pertains to global pandemics) up to 25% to other Turnstone sites
• Proven track record of strong contributions demonstrated by highly cited publications, impactful tools, products, or data sets used by the scientific community, presentations at international conferences, and awards.
• Deep expertise in cancer genomics
• Track record of scientific contributions to successful drug or diagnostic development programs
• Experience with NGS software workflows and analysis of single cell, whole exome, or targeted NGS sequencing data (DNA and RNA) on Illumina HiSeq/MiSeq sequencers
• Experience with Illumina NGS workflows including library construction, hybrid capture enrichment, or amplicon-based sequencing
• Collaborative development skills using version control systems (e.g., Git)
• Familiarity with using virtualized working environments such as Docker
• Experience working in the cloud (AWS), on a Linux based high-performance computing cluster, and contributing to shared code bases is desirable
• Proficiency with statistical analysis in R or Python, and data visualization highly desirable
• Experience with ELN and LIMS systems is desirable
• Working knowledge of RNA-Seq, flow cytometry, variant calling, single cell genomics analysis is preferred
• Lead authorship roles on high-impact publications is desirable
• Experience in supporting informatics in the FDA regulated / GMP manufacturing setting is desirable
• Working understanding of innate and adaptive immune systems is preferred
• Able to work effectively in a fast-paced, small biotech environment
• Willingness to roll-up sleeves and pitch in to help team hit milestones
• Strong ability to prioritize, multi-task, and work in an evolving environment
• Excellent presentation and written / verbal communication skills
• Strong interpersonal skills and a communication style that matches the Turnstone style: respectful, transparent, and constant
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
The Research Associate or Senior Associate, in this individual contributor, lab-based role, will work in a collaborative environment to perform Analytical testing and development to support Turnstone’s TIL cell therapy development programs. This position will join the development group and work with the analytical testing group that values data quality, high productivity and teamwork. The key deliverables for this role are precise, accurate, and high-quality data presented, communicated, and integrated in an effective manner. This position will require thorough documentation of all experimental steps and final data readout.
Responsibilities:
• Execution of key analytical methods such as multi-parameter flow cytometry, bioassays and qPCR-based methods and data analysis in support of process development activities, product characterization, and raw materials testing.
• Provide support to other groups for assay development, qualification, and transfer into Analytical Development
• Developing processes and methods to improve lab execution and data analysis
• Timely and thorough documentation and completion of electronic laboratory notebooks
• Author reports detailing experimental work and summarizing results
• Contribute to an overall high-performing laboratory, with a willingness to contribute in all ways, such as ordering, tracking, and maintaining inventory of lab supplies and reagents
Experience & Qualifications:
• BS in a scientific discipline 2+ yrs experience (1+yrs with MS) of relevant industrial experience. Final role can be commensurate with relevant industry experience.
• Experience with flow cytometry or cell-based bioassays, ELISA, and PCR techniques
• Experience with aseptic cell culture and cell-based assays.
• Ability to follow laboratory procedures with attention to detail, and successfully execute experiments at the bench.
• Experience with other techniques in molecular biology, such as RT-PCR is preferred
• Previous experience with cell therapy products is preferred
• Demonstrated ability to effectively work in cross functional teams, meet deadlines, and prioritize multiple projects
• Experience working in a self-driven, performance/results oriented, fast paced matrix environment
• Working knowledge of statistical software (R, JMP, Minitab) is preferred.
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
As an Engineer or Sr. Engineer (depending on your relevant experiences and expertise), you will provide process development and engineering support for process design, characterization, and improvements with a goal of ultimately enabling GMP manufacturing. Primary responsibility will be to design, lead, and execute experiments that contribute to development and characterization of the TIL cell therapy manufacturing process. Experiments will be performed to identify and define Critical Process Parameters and process ranges. Additionally, you will draft and review study plans and reports, analyze and trend process data, perform Design of Experiments (DoEs), and provide technical support for manufacturing sciences, technology, and process changes. Turnstone works in a highly cross-functional environment, so your contributions will be critical for our pre-clinical, clinical, and regulatory workflows, with an opportunity to engage and enable your colleagues across the business.
Responsibilities:
• Develop manufacturing processes for cell therapy products and develop process improvements and efficiencies
• Lead and execute laboratory studies to support process design and development, characterization and process improvements
• Write and review technical documentation
• Participate and report to a cross-functional development team to advance production activities
• Assist in technology transfer to GMP manufacturing by generating development reports and providing on-site technical support.
• Authoring and assistance in the technical review of supporting documents, reports, including CMC sections for regulatory filings.
• This is a hands-on position requiring conducting laboratory experiments, good documentation review skills, good writing skills, and the flexibility to move between the management and execution of each required function as needed.
• Act as technical expert to train and supervise process technicians
Experience & Qualifications:
• Minimum of 3 years of relevant industry experience, with role flexibility available commensurate with experience
• Degree in Biochemical Engineering, Chemical Engineering, Biomedical Engineering, Biotechnology or related discipline with pharmaceutical/biotech manufacturing & process development experience required
• Fluency with cGMP manufacturing and regulatory regulations and requirements for pharmaceuticals and devices
• Cell culture and aseptic processing experience
• Working knowledge of scientific and engineering principles
• Experience in statistical analysis using JMP or Minitab
• Practical experience in GMP operations
• Ability to function efficiently and independently in a changing environment
• Self-motivated and willing to accept temporary responsibilities outside of initial job description
• Excellent interpersonal, verbal and written communication skills are essential in this collaborative work environment
• Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities
• The primary location of the position is San Diego, but may be required to travel, based on business priorities
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
As the Sr. Engineer/Sr. Scientist of upstream process development, you will report to the Head of Drug Substance Process Development. As part of this role, you will lead all of the technical aspects of our virus process development program across cell line, media/feed strategies, infection/harvest and bioreactor scale up and development. You will be a critical member of our Process Development team and help contribute to the overall strategy and execution of our virus CMC and translation. Specifically, you will:
· Develop the upstream process development targets and strategy to reach our program needs across a suite of virus-based drug products
· Contribute as the subject matter expert to the overall upstream process development of our virus pipeline supporting cell line development, media development, feed strategy development, infection and harvest conditions, and bioreactor scale up
· Lead interactions with our external CDMO network to accomplish efficient process development advancement
· Collaborate with Drug Product development, Manufacturing Sciences and Manufacturing Operations to support smooth translation of processes through inception to clinical manufacturing
· Participate in technology transfer of our processes to local and international GMP partners
· Support Manufacturing Sciences team with scale-up of the manufacturing processes, and deviation investigations
· Employ QbD principals to perform process characterization studies
· Act as subject matter expert for review of data in regulatory filings
What’s in it for you?
In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size (approximately 100 team members, and growing fast!) we will give you plenty of opportunities to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!
We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.
Experience
Turnstone Technical Operations is a virtual organization, where the majority of our wetbench work is executed at third party CMO/CRO partners. We have offices in Ottawa, Canada and San Diego, USA and this role would ideally inspire you to relocate. Most of our virus development team is stationed in Ottawa and most of our partnerships are in Europe – therefore being in Ottawa would be ideal, but if you believe you can be successful in San Diego, we would love to speak with you! This role is best suited for someone with the following:
· Scientist or Engineer with advanced degree in Biochemical Engineering, Biotechnology or in other related Science field (virology, biology, biochemistry, protein chemistry, pharmaceutical chemistry)
· 5-7 years of experience in upstream process development within biotech/pharma
· Experience with process scale up, deployment and technology transfer of complex biological processes in a GMP manufacturing environment, and process qualification/validation are strongly preferred
· Proven expertise and technical depth in upstream process development (mammalian cell culture expression systems, ideally for the manufacture of live-viruses) is required
· Experience with media and feed development strategies
· Expertise in microcarrier, and aseptic process experience, is strongly preferred
· Experience leading bioreactor development workstreams and support scale up from benchm, to pilot, to GMP scale SUB
· Excellent communication skills with the proven ability to build open and collaborative relationships, work effectively as a member of a multidisciplinary team
· Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency, and function effectively in a fast-paced and dynamic environment
· The candidate must exude a mature communication style that matches the Turnstone style: respectful, transparent, with a high degree of integrity and humility
· Able to manage competing priorities effectively and adapt to changing priorities
· Analytical and quantitative approach to problem solving, with the ability to self-start and independently investigate technically challenging problems
· Excellent computer skills, including JMP, Microsoft Excel, Powerpoint and Word
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
The Logistics Specialist will be a part of the Logistics Team and broader Manufacturing and Supply Chain Team which is responsible for a global portfolio of logisitics operations across multiple product modalities (virus and cell therapies) and core business functions (R&D, Tech Ops). Will be focused on handling logistics in support of the rapid development of our cell therapy products. Relevant regulatory, brokerage, and cold chain shipping experience within the context of autologous cell therapies is a firm requirement.
The Specialist will report to the Manager, Logisitics (member of the Extended Technical Operations Leadership team at Turnstone).
Responsibilities:
Quoting, arranging, and handling of time-critical and temperature-controlled shipments.
Identify and select carriers and vendors who will meet service requirements for shipments
· Determine pick-up and export routing, documentation requirements, and filing of custom queries upon request.
· Log, track and analyze for final KPI’s all the data from each shipment, must maintain accurate and organize records and chain of custody
· Support team members with other duties as required, such assisting requestors with problem resolution and owning the projects from beginning to end.
· Work with external partners Brokers, CMOs, CTO’s, Storage Vendors.
· Participate in cross-functional teams that support process improvements and/or team development.
· Identify and resolve delivery related issues through timely communication with internal teams, carriers, and external partners.
· This is a global role; candidates must be cognizant of time zones and flexible enough to be able to work within them
Qualifications and Experience:
· Bachelor’s degree in a scientific, business or related discipline
· Ability to function in a team environment and pursue information when it is not readily available. Comfortable in a fast-paced company environment and able to adjust workload based upon changing priorities, and willing to accept temporary responsibilities outside of initial job description
Strong communication skills to ensure regular and effective communication within the business and externally with 3rd parties.
Customer service focused/mindset / Continuous Improvement mind-set
Used to working at a high speed in a fast-paced, dynamic environment.
Familiarity with international supply chain constituents; brokers, freight forwarders, freight providers, carriers, CMOs/CROs, depot/warehouse providers, and regulatory standards such as permits, labeling and transportation rules.
Knowledge of Packing and Material Management operation in accordance with GMP manuals and guidance as well as experience with transport and temperature control practices such as, temperature monitoring, labels required bu the TSA and DOT, types of labeling codes and Harmonized tariff input.
· Experience maintaining spreadsheets and other databases of information as required.
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
As the Associate Director of Formulation and Drug Product Development, you will provide leadership to a team of Scientists, drive the strategic development plan and direct all Drug Product (DP) and formulation development efforts to support our viral-based platforms (RIVAL). Reporting to the head of viral development, you will:
· Participate as an active member of the Viral Development leadership team, to support overall analytical and process development needs across Drug Substance and Drug Product development
· Manage a cross-functional matrix team (Clinical, Supply Chain, Regulatory, Quality, Tech Ops) to develop overall Drug Product development strategy for a suite of viral-based products
· Provide leadership and guidance to a small team of Scientists
· Drive development of improved viral delivery systems (IV infusion, IT or IM injections) to enable optimization of pharmacy DP handling and administration
· Develop and drive the overall stability program strategy at all key stages of manufacture
· Work closely with the Analytical Development team to ensure appropriate and robust assays are in place to enable stability assessments, and drug product characterization
· Lead all aspects of pre-formulation and formulation development across a range of DP images (liquid, and lyophilization)
· Drive to definition of DP critical quality attributes through forced degradation studies and advanced analytical tools
· Support biophysical analytical development and design of characterization studies
· Participation in regulatory strategy and document authoring/reviewing for interactions with FDA, EMA, Health Canada, MFDS, and other jurisdiction as they emerge
What’s in it for you?
In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!
We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.
Experience & Qualifications:
Turnstone Technical Operations is a virtual organization, where nearly all of our wetbench work is executed at third party CMO/CRO partners. We have offices in Ottawa, Canada and San Diego, USA and ideally you feel motivated to relocate for this role to one of those sites. Most of our virus development team is stationed in Ottawa Canada, and most of our partnerships are in Europe – therefore relocating to Ottawa would be ideal, but if you feel you can be successful from San Diego, then let’s chat! This role is best suited for someone with the following:
· 8-10 years of overall experience within the biotech/pharmaceutical industry
· Minimum of 3 years of leadership experience demonstrated as either having direct reports, and/or demonstrated leadership across complex projects and cross functional teams
· Scientist with advanced degree (PhD strongly preferred but not required)
· Strong interpersonal skills required
· Experience developing and/or interpreting biophysical analytical methods
· Expertise developing novel formulations (experience developing live virus formulations considered a very strong asset)
· Experience working with drug transfer devices and planning pharmacy handling procedures
· Expertise managing stability programs, including knowledge of relevant regulatory guidances, considered a strong asset
· Educated in one of the following fields: Biochemical Engineering, Biological/Biomedical Engineering, Virology, Biology, or Biochemistry
· Experience designing, and planning accelerated studies to evaluate degradation pathways and define CQAs
· Excellent computer skills, including Microsoft Excel and Powerpoint
· Able to manage competing priorities effectively and adapt to changing priorities
· Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency, and function effectively in a fast-paced and dynamic environment
· The candidate must exude a mature communication style that matches the Turnstone style: respectful, transparent, with a high degree of integrity and humility
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.
At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
Reporting to the Chief Financial Officer, this role will be responsible for managing the global accounting and finance function of Turnstone Biologics Corp. The Controller will oversee general and technical accounting, budget and forecasting management, tax operations and planning, equity administration, and, in the event the company undertakes an initial public offering of its securities, SEC reporting and compliance. The position will be directly involved with some or all the following.
Responsibilities:
Accounting and Controls
· Develop accounting and reporting systems and policies to ensure compliance with generally accepted accounting principles. Oversee timely and efficient monthly and quarterly closing and reporting process. On transition to a public company, ensure accurate and timely SEC filings (10-K, 10-Q, 8-K)
· Lead the annual audit process, prepare all supporting information for the annual audit. Develop strong partnership with external auditors to ensure clean audit sign offs and efficient quarterly reviews
· Consult with appropriate resources to ensure that new accounting guidance are analyzed and understood from an accounting standpoint. Communicate impact of technical accounting matters to executive management as necessary.
· Own and drive efficient and effective delivery of accounting services across Turnstone, to include general accounting, account receivables, payables and payroll. Collaborate with IT to drive development of appropriate financial systems to support accounting operations.
· Partner with legal and business development on contractual terms to assess financial and accounting impact and oversee financial compliance with all significant contractual obligations
· Help lead fundraising and financing efforts, working closely with the executive team. Help manage ongoing relationships with financial institutions.
· Prepare and present financials to the company, Board Audit Committee and key stakeholders.
· Develop, implement and monitor internal controls and financial policies and procedures to ensure that the organization’s day-to-day operational activities are efficient and effective, and investments are in-line with budgets.
Financial Planning & Analysis
· Lead all aspects of financial planning, budgeting and forecasting. Work closely with business partners and the executive team to plan for key revenue and cost drivers.
· Develop annual budgets for the review and approval of Management and the Board of Directors; ensure that input is provided by Project Managers in the development of budgets and forecasts.
· Prepare and provide quarterly detailed financial reporting packages (budget/cash flow forecasting/variance analysis) to Management, the Board of Directors and Investors of the organization
· Develop the financial reporting infrastructure (e.g., program and function P&Ls) to enable strategic decisions, ongoing analysis and performance tracking by the executive team
Tax and Treasury
· Manage global tax compliance with all required federal, state, local, payroll, property and other applicable taxes. Ensure that the organization makes all required government remittances and remits applicable taxes in which it operates
· Oversee cash management and act as the company’s treasurer
· Manage stock plan administration activities
· Assist with the management of business insurance requirements
Experience & Qualifications:
-
Qualifications:
· Undergraduate degree in business administration, accounting, finance, economics or related field is required; CPA required
· 15 years or more experience with progressively increasing responsibilities and leadership roles with significant experience in Accounting function
· Life science experience is required
To Apply:
Please click here to apply!
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Contact
New York City
920 Broadway, 16th Floor,
New York, NY 10010, US
(347) 897-5988
Ottawa
12 York Street, 3rd Floor,
Ottawa, ON K1N 5S6, CA
(613) 421-8930
San Diego
Center for Novel Therapeutics
9310 Athena Circle
La Jolla, CA 92037, US
(347) 897-5988