Leading the FightAgainst Solid Tumors
About Us
Pioneering Novel Approaches
to Deliver on the Promise of TILs
At Turnstone, our mission is to develop and deliver new medicines to treat patients with solid tumors.
Solid tumors represent the greatest unmet need in oncology. They account for over 90% of all cancer cases and contribute a substantial disease burden to society. Approved immunotherapies have been a significant advancement in the treatment of solid tumors, however, many patients do not respond to such therapies and the vast majority of these patients experience relapsed disease. We believe the biggest challenge in creating curative immunotherapies for patients with solid tumors is the large number and diversity of T-cells, known as tumor-reactive T-cells, that are needed to recognize and attack the tumor.
To overcome this barrier, we are pioneering a next-generation approach with tumor-infiltrating lymphocyte (TIL) therapy based on the identification, selection and expansion of these tumor-reactive T-cells (Selected TILs). We are advancing a differentiated pipeline of Selected TIL therapies to address the most significant challenges in the field, including their development in clinical combinations with our proprietary viral immunotherapies, to further potentiate the therapeutic benefit of our TILs.
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One Turnstone
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One Focus
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One Fight
Leadership
Experienced Team of
Leaders and Innovators
Turnstone has assembled a seasoned management team, an accomplished Board of Directors and a distinguished Scientific Advisory Board whose contributions to science have meaningfully advanced the field and helped inform our understanding of the relationship between cancer and the immune system.
Our passionate team of leaders comprises world-renowned professionals with deep expertise in TILs, cell therapy, tumor immunology, innate and adaptive immunity, oncolytic viruses, and in the discovery and development, manufacturing, and business and commercial development of complex biologics.

Sammy Farah, PhD, MBA
President & Chief Executive Officer

Stewart Abbot, PhD
Chief Scientific Officer

Saryah Azmat
Chief Business Officer

Christine Blodgett
Vice President, Human Resources

Mike Burgess, MBChB, PhD
Interim Chief Medical Officer

P. Joseph Campisi, Jr., Esq.
General Counsel

José Manuel Otero, PhD
Chief Technology Officer

Venkat Ramanan, PhD
Chief Financial Officer

David Stojdl, PhD
SVP, Discovery Research

Chad Green, PhD
SVP, Technical Operations

TJ Langer
SVP, Cell Therapy Development and External Innovation

Adina Pelusio
SVP, Clinical Operations

Karen Major
VP, Regulatory

George Smith, MBA, PhD
VP, Cell Therapy Business Operations

James Mulé, IPhD
Scientific Director of Cell-Based Therapies
Moffitt Cancer Center

Eric Tran, PhD
Adoptive Cell Therapy Laboratory Lead
Providence Cancer Institute

Jerel Davis, PhD
Chairman & Director
Versant Ventures

Mike Burgess, MBChB, PhD
Executive Director
Turnstone Biologics

Sammy Farah, PhD, MBA
Director
Turnstone Biologics

Robert Gould
Director
Fulcrum Therapeutics

Rishi Gupta, JD
Director
OrbiMed

Stefan Larson, PhD
Director
Sectoral Asset Management

Patrick Machado
Director
Former CFO/CBO Medivation

Santhosh Palani, PhD
Director
PFM Health Sciences

Kanya Rajangam, MD, PhD
Director
Senti Biosciences

Jeff Courtney
In Memoriam
Our Approach
Pipeline
Designed to Shift the Paradigm
for the Treatment of Solid Tumors
Our Selected TIL approach has the potential to drive therapeutic benefit and curative outcomes across multiple challenging solid tumors. Leveraging our Selected TILs as well as our viral immunotherapy, we are advancing a broad pipeline aimed at overcoming limitations in existing treatments for cancer patients with critical unmet need.
Platform | Program | Overview | Indication | Discovery | Preclinical | Phase 1/2 | Phase 3 | Study Collaborator |
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Selected TILs
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TIDAL-01 | Neoantigen selected tumor-specific TILs to drive TIL product potency | Cutaneous Melanoma Uveal Melanoma |
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Breast Cancer Colorectal Cancer |
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Combination with proprietary oncolytic viral immunotherapy | Colorectal Cancer |
OV monotherapy dose escalation ongoing
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TIDAL-02 | Broad antigen selected tumor-specific TILs with streamlined manufacturing and TIL quality enhancements | Cervical Cancer Head & Neck Cancer Lung Cancer |
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TIDAL-03 | Engineered selected TILs optimized for functional persistence and elimination of IL-2 toxicities | Solid Tumors |
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Viral Immunotherapy
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RIVAL Discovery | Takeda collaboration for novel viral immunotherapies | Undisclosed |
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Selected TILs | |||
Discovery | Preclinical | Phase 1/2 | Phase 3 |
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TIDAL-01 ![]() +
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TIDAL-01 +
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TIDAL-01 ![]() |
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TIDAL-02 ![]() |
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TIDAL-03 |
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Viral Immunotherapy | |||
Discovery | Preclinical | Phase 1/2 | Phase 3 |
RIVAL Discovery ![]() |
Takeda maintains right to license select RIVAL Discovery program candidates
OV (oncolytic viral) monotherapy dose escalation trial ongoing – Clinical trial identifier: NCT04301011
Partners
Optimizing Technological Innovations
Through Strategic Partnerships
We are backed by successful top-tier life science and biotech investors committed to Turnstone’s growth, and have forged select collaborations with key academic institutions, major biopharmaceutical companies, elite researchers and prominent international cancer medical centers to accelerate the development of our next-generation Selected TIL and immunotherapy pipeline.
Together with our strategic partners, we are devoted to delivering transformative therapies to the millions of cancer patients underserved by current treatment options.
Key Collaborators
In November 2022, Turnstone announced a Cooperative Research and Development Agreement with the National Cancer Institute (NCI) to study TIL therapy in novel combinations with viral immunotherapy.
In April 2022, Turnstone announced a TIL therapy research collaboration with CRCHUM to develop novel strategies for tumor-reactive T-cell selection in Turnstone’s TIL therapy candidates against solid tumor indications.
Select Investors
News
Careers
Empowering Our People
to Drive Science Forward
Turnstone is committed to true innovation, fearless execution and operational excellence. Our team work with an unrelenting sense of urgency to fulfill our mission. Our decision-making is driven by bold science and our therapeutics are designed with the patient at the forefront of our thoughts.
We continue to build a values-driven organization that embraces diversity, equity, and recognizes that the sum of our parts drives more success than any single individual. Our talented people and deeply ingrained culture are vital elements in maintaining our competitive edge in the vast biotech universe and key to unlocking the full potential of cancer immunotherapy.
If you are passionate about making a difference for patients and are excited by our mission and science, Turnstone might just be for you.
Team Opportunities
Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.
At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.
What would the role be like?
Turnstone Biologics is seeking a Senior Scientist to join the Translational Medicine team to play a key role in defining the kinetics and mechanisms of action of our TIL therapy. Turnstone’s T cell therapy platform generates an exciting new selected TIL drug product that revolutionizes the generation of tumor-targeted T cells for adoptive cell therapy. We track engraftment of the drug and dive deep into the mechanism of action in the periphery and in the tumor. This is an exciting opportunity to work alongside the clinical team and senior scientists in Discovery Research, Process Development, and T cell manufacturing to perform translational research that will deepen our understanding of mechanisms of action of our novel TIL therapy.
We have an open, transparent and dynamic culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements. If you are passionate about immunology with experience in T cell biology, flow cytometry, cell-based and co-culture assays, and are looking to make an impact on behalf of patients, then this opportunity is just what you are looking for.
What’s in it for you?
In this role, you will work closely with Translational Medicine leadership to develop and execute plans for clinical sample analysis. Explore T cell phenotypes and mechanisms of action that correlate with response using blood and tissue samples from patients treated with our cutting-edge therapies. We want you to develop your ability to think strategically and mentor others while driving fast-paced execution in a highly collaborative and cross-functional environment. With our company size and growth you will have plenty of opportunities to be an inspirational and collaborative leader.
The Responsibilities include the following:
- Design, develop, and optimize flow cytometry and cell-based in vitro assays to determine pharmacokinetics, pharmacodynamics, safety, and efficacy of our TIL therapy products.
- Work closely with manufacturing to characterize tumor-reactivity of drug product and on-treatment samples.
- Understand on-treatment T cell activity, function, cell states, activation and exhaustion phenotypes.
- Generate data, create figures, and communicate translational results and future plans with key stakeholders.
- Collaborate with clinical, discovery research, process development, and manufacturing teams to determine therapeutic mechanisms of action.
- Ensure high ethical standards and that study reports are accurately generated in a timely manner .
- Supervise and/or mentor team members.
- Contribute meaningfully to a team-centric culture that embraces scientific excellence, integrity, and urgency.
How do you know if you’re the right fit?
- Ph.D. in Immunology/Oncology (research primarily focused in immunology) with multiple years post graduate experience and/or biotech or pharmaceutical industry experience.
- Expert knowledge of cell-based in vitro assays, multi-parameter flow cytometry, and common molecular techniques.
- Robust understanding of innate and adaptive immune cells in anti-tumor responses is required.
- Deep knowledge and experience in T cell function/differentiation/signaling/regulation, metabolism/phenotypic analysis, understanding of inhibitory and costimulatory targets and pathways and/or neoantigen biology and vaccines is highly preferred.
- People management and project leadership experience is preferred.
The anticipated salary range for this role is $120,000 – $145,000.
To Apply:
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.
At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.
What would the role be like?
We are looking for a Research Associate to join our Translational Medicine team of immunologists and support the analysis of clinical samples. You will work alongside senior researchers and supporting technical colleagues within project teams at our state-of-the-art facilities in San Diego. Your role would be to perform cell-based translational immunology studies, scrutinize your data, and present your results in a collaborative team setting. This is an exciting opportunity to help us understand the qualities of our TILs and their mechanism of action in samples from our patients treated in clinical trials.
What’s in it for you?
This is a chance to develop your skills and gain experience by working closely with a strong team of immunologists. We are exploring T cell phenotypes that correlate with response using blood and tissue samples from our patients. We want you to learn from our established procedures and develop your experimental abilities to contribute to the understanding of our cutting-edge therapies. If you are passionate about immunology with experience in T cell biology, flow cytometry, cell-based and co-culture assays, and are looking to make an impact on behalf of patients, then this opportunity is just what you are looking for.
The Responsibilities include the following:
- Characterization of TIL drug products for tumor-reactivity and cytotoxic potential by co-culturing TILs with tumor antigen-pulsed antigen presenting cells.
- Use flow cytometry to measure T cell differentiation, cytotoxicity, expansion, cytokine seceretion, and activation and exhaustion phenotypes.
- Isolate and cryopreserve immune cells from patients’ blood samples.
- Explore additional characterization of human blood and tumor samples to support development of novel biomarker assays.
- Generate data, create figures, and communicate results with Translational Medicine leadership.
- Ensure high ethical standards and that study reports are accurately generated in a timely manner.
- Work closely with other team members to learn from and share knowledge.
- Contribute meaningfully to a team-centric culture that embraces scientific excellence, integrity, and urgency.
How do you know if you’re the right fit?
- B.S or M.S in Biology with previous experience in immunology is required.
- Must have extensive experience with mammalian and immune cell culture with excellent sterile technique.
- Experience with multi-parameter flow cytometry, ELISA, nucleic acid extraction, and sequencing, is preferred.
- Experience with molecular biology techniques and cellular transfection is preferred.
- Strong work ethic, positive team-oriented attitude is a must!
The anticipated salary range for this role is $70,000 – $85,000.
To Apply:
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.
At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.
Position overview:
We are seeking an enthusiastic and driven Scientist with a strong background in immunology and genomics to join our team of immunologists driving the development of Selected-TIL therapies for the treatment of cancer. The successful candidate will deploy functional genomics, single cell sequencing and cellular immunology to support preclinical programs advancing our TIL platform. In this role, you will have the opportunity to develop your ability to think strategically, drive fast-paced execution, and collaborate with team members across the research department.
The Responsibilities include but are not limited to the following:
- Contribute to target evaluation and validation for select TIL improvement using in vitro assays such as cytotoxicity, expansion, and cytokine secretion.
- Genetically engineer immune cell populations and screen for novel targets.
- Contribute to product characterization and target identification using gene expression profiles, genome annotation, TCR sequencing and single cell RNA sequencing data.
- Independently design, execute, analyze, and troubleshoot experiments to support preclinical discovery in discovery in immunology therapeutic areas.
- Communicate and collaborate effectively with colleagues to drive progression of the project.
Experience:
- Ph.D. with a strong background in Immunology and bioinformatics or computational biology.
- Experience with current NGS platforms including single-cell analysis algorithms.
- Advanced immunology laboratory skills, with demonstrated proficiency in multi-parameter flow cytometry biochemical, immunological and cell biology techniques.
- Proficiency in R or Python is highly preferred.
- Prior experience in analyzing and integrating TCR-seq or CITE-seq datasets is preferred.
- Experience with genetically engineering primary immune cells using CRISPR-based approaches is preferred.
- Experience with guide-seq, circle-seq or site-seq is a plus.
- Excellent written and oral communication skills, including an ability to explain complex ideas to other team members.
- Strong interpersonal skills and a communication style that matches the Turnstone style: respectful, transparent, and constant.
The anticipated salary range for this role is $100,000 – $125,000.
To Apply:
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.
At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
We are seeking a passionate and driven Research Technician/Associate to join our team of immunologists driving the development of Selected-TIL therapies for the treatment of cancer. The successful candidate will provide support and assistance to senior researchers at our San Diego site using state-of-the-art instrumentation and following established laboratory standard operating procedures (SOPs). In this role, you will have the opportunity to develop your ability to think strategically, drive fast-paced execution, and collaborate with team members across the research department.
The Responsibilities include but are not limited to the following:
- Molecular editing of immune cell populations and rapid expansion.
- Validation of editing using PCR and western blot or flow cytometry.
- Assessment of TIL phenotype using flow cytometry.
- Isolation of tumor and immune cells from patient samples.
- Assessment of TIL functionality using in vitro assays to measure cytotoxicity, expansion, and cytokine secretion.
- Support other team members by preparing reagents and materials.
- Generate quality data and study summary reports in a timely manner.
- Contribute to a team-centric culture that values transparency, innovation, integrity, and purpose.
Experience:
- B.S in Biology with previous experience in immunology is required.
- Must have experience with immune cell culture with excellent sterile technique.
- Experience with multi-parameter flow cytometry is preferred.
- Experience with lentiviral and/or CRISPR-CAS9 techniques for editing and engineering immune cells is a plus.
- Experience with DNA isolation, PCR, and western blot analysis is a plus.
- Experience with tumor digestion and cell sorting is a plus.
- Strong work ethic, positive team-oriented attitude is a must.
The anticipated salary range for this role is $70,000 – $85,000.
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
To Apply:
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.
At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
Turnstone is seeking a Research Associate to join our team of immunologists driving the development of TIL therapies for the treatment of cancer. This successful candidate will drive various aspects of in vitro by designing and executing experiments, analyzing data and presenting results in a collaborative team setting. This is an exciting opportunity to work alongside senior researchers and project teams to perform discovery and development research that will ultimately create new medicines for cancer patients at our state of the art facilities in San Diego. We have an open, transparent and dynamic culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.
The Responsibilities include but are not limited to the following:
- Perform isolation, expansion and phenotyping of various immune cell populations (T cells, DCs and B cells) for use in immunologic assays.
- Design, execute and analyze in vitro studies to assess TIL expansion, phenotype and functionality.
- Assessment of TIL phenotype using flow cytometry (from simple to complex panels, including spectral cytometry)
- Assessment of TIL functionality using in vitro assays to measure cytotoxicity, expansion, and cytokine secretion.
- Generate quality data and study summary reports in a timely manner.
- Prepare data/figures to present to senior research staff.
- Contribute to a team-centric culture that values transparency, innovation, integrity, and purpose.
Preferred Experience:
- B.S or M.S in Biology with previous experience in immunology.
- Extensive experience with mammalian cell culture with excellent sterile technique.
- Experience with multi-parameter flow cytometry.
- Experience with Immune cell culture and functional assays.
- Experience with cell sorting is a plus.
- Strong work ethic, attention to details and positive team-oriented attitude is a must.
The anticipated salary range for this role is $70,000 – $85,000.
To Apply:
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.
At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.
Position Overview:
Turnstone’s T cell therapy technology is based on a Selected-TIL process that revolutionizes the generation of tumor targeted T cells for adoptive cell therapy. We are looking for a passionate and driven team player with experience in molecular biology, cell culture, flow cytometry and immunologic assays to help develop these next gen T cell products for preclinical and clinical evaluation. You will work alongside senior researchers at our Ottawa research facility (located at Carleton University), designing and executing cell-based immunology studies following established standard operating procedures (SOPs). In this role, you will have the opportunity to develop your ability to think strategically, drive fast-paced execution and collaborate with team members across the research department.
Responsibilities include but are not limited to the following:
- Design, execute and analyze in vitro studies to assess TIL expansion, phenotype and functionality.
- Co-culture of TIL and tumor cells for assessment of T cell reactivity by cytokine secretion, proliferation and cell killing.
- Generate quality data and study summary reports in a timely manner.
- Communicate findings to senior research staff.
- Contribute to a team-centric culture that embraces scientific excellence, collaboration, innovation, integrity and hard-work.
Requirements:
- Scientific degree with Immunology experience is required.
- Multi-parameter flow cytometry experience is required.
- Must have experience with mammalian cell culture, experience with immune cell culture is preferred.
- Strong work ethic with a positive team-oriented attitude.
- Ability to effectively multi-task and adapt in a fast-paced environment.
To Apply:
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.
At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.
Job Summary
The Director, Clinical Data Management & Biostatistics will take the data management lead on outsourced Phase I/II/III studies. Since the studies are outsourced, the individual will provide vendor management oversight including biostatistics services and strategic biostatistics consultants as well as review of DMPs, CRFs, DVS, perform UAT, etc. The individual must be an experienced Data Manager who is able to work independently and cross functionally. This individual must be self-motivated and collaborative amongst internal stakeholders as well as external and CRO partners as appropriate.
Responsibilities
- Responsible for assessing in house data management needs and driving the selection and implementation of any in-house data management solutions including developing policies and procedures
- Responsible for clinical data management activities for outsourced studies
- Ensures data management activities for clinical trials within assigned research program(s) are completed in a timely and accurate manner
- Leads statistical and programming vendors to plan and implement statistical and programming project plans
- Develops proposal requests to service providers; evaluates and approves service level agreements
- Oversees service providers to perform core data management functions including IWR/IVRS, CRF, edit check and CRF completion guidelines development, user acceptance testing, data cleaning, reviewing listings, and database locking procedures
- Works collaboratively with Biostatistics and Programming during data integration leading up to a regulatory filing
- Establish inter- and intradepartmental processes to improve the efficiency and quality of data processing
- Leads and manages DM tasks outsourced to external vendors and ensures that milestones, deliverables, quality and timelines are met within budget and in accordance with regulatory requirements.
- Develops positive partnerships with CROs and ensure a high standard of deliverables are maintained.
- Serves as the DM focal point on assigned studies for all local interfaces and preserves a fluent workflow with the other interfacing departments and local procedures and processes.
- Prepares and maintains timelines for the assigned studies and communicates to management any issues so that appropriate actions can be taken.
- Prepares status reports and updates for data management as required
- Collects and monitors study metrics
- Plans and oversees preparation of safety committee data management as well as annual report data management Approves data management plans for completeness and accuracy of required documentation
- Oversees, review of the DMP and other pertinent documents for all assigned studies.
- Oversees and performs UAT on CDMS components as needed.
- Provides input into CDMS requirements, assuring protocol requirements are met.
- Supports validation efforts to minimize the company’s exposure to regulatory risk by validating all electronic data streams and systems in support of organizational objectives
Skills, Qualifications, And Requirements
- BS Life Sciences or Computer Science
- 8-10 years of data management experience in a clinical research setting
- Strong working knowledge and prior experience directly managing/overseeing service providers and CRO’s is required
- Prior experience managing clinical data for multiple studies at one time
- Experience with computerized clinical data management systems is required
- Knowledge of SAS and database programming
- Systems integration experience
- Understanding of CDASH and CDISC standards
- Ability to work independently and collaboratively in a fast-paced, matrixed team environment consisting of internal and external team members
- Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines
The anticipated salary range for this role is $175,000 – $210,000
To Apply:
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Turnstone Biologics is a clinical stage biotechnology company developing new medicines to treat and cure solid tumors by pioneering a differentiated approach with a clinically validated technology, tumor infiltrating lymphocyte (TIL) therapy. Turnstone’s innovative TIL therapy, which is designed to extend the efficacy of TILs to multiple solid tumor indications by selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) for tumor eradication, represents the Company’s foundational therapeutic modality driving its cancer immunotherapy pipeline. The Company recently commenced two clinical trials in various solid tumor types with its lead Selected TIL therapy candidate, TIDAL-01, one of which is in collaboration with Moffitt Cancer Center. Turnstone is developing additional strategies to further potentiate the clinical benefit of Selected TILs, including use in combination with their novel viral immunotherapy.
At Turnstone, the science drives decision-making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’. If you are a passionate person, and our science excites you – this opportunity may be for you.
Job Summary
Reporting to the Vice President, Clinical Development, the Director, Clinical Science will be a key contributor to Turnstone’s clinical development programs. The Director is supporting the planning and execution of clinical studies in a timely manner, in adherence with GCP, appropriate SOP’s and government regulations. He / She also conducts ongoing medical/safety data reviews, plans and supports study reporting and acts as a primary point-of-contact for site specific clinical questions.
Responsibilities
- Under the direction and oversight of the VP, Clinical Development, design, oversee and/or execute, as needed and as appropriate, key clinical deliverables including document development necessary for study design, activation, conduct and reporting (protocols, ICFs, IBs, CRFs, SAPs, Clinical study reports (CSRs).
- Assume a lead role in clinical study data review and interpretation and contribute to the development of deliverables required for ongoing study data review process.
- Work closely with individuals in other functional areas (e.g., clinical operations, project and program management, safety and pharmacovigilance, regulatory affairs and quality, pre-clinical and research, manufacturing, finance, contract resources, vendors etc.) in the creation, management, and execution of the clinical development plans, in developing innovative and efficient solutions to medical and scientific clinical trial issues, and ensuring the successful execution and completion of Turnstone’s clinical trials.
- Contribute content to regulatory submissions (INDs, NDAs, MAA etc.) as well as to documents to support Regulatory Authority interactions (briefing books, response documents etc.).
- Provide medical and scientific input and generate content for abstracts, posters, presentations and manuscripts.
- Contribute medical and scientific input into the Clinical Development Plans for preclinical and early-stage clinical assets.
- Identify risks, develop risk mitigation plans, and escalate risk mitigation strategies as appropriate.
- Contribute to and optimize an effective KOL and investigator communication strategy, interacting with investigators as warranted to obtain necessary information before, during and after the study.
- Working with other departments, create functional policies and procedures to provide strong and efficient clinical development processes that are appropriate for a matrixed environment.
- Ensure that relevant SOPs are current and complete.
- Assess, recommend, track functional budgetary and staffing needs for medical/clinical aspects of clinical trials
- May also assist with other broad or diverse activities as needed, and when appropriate, including Clinical Development activities (e.g., contributing to the development of an IND for a preclinical asset, etc), Business Development activities (e.g., contributing to Search and Evaluation efforts, Diligence, etc), or other non-clinical departmental activities.
- Other related duties as assigned.
Qualifications
- Advanced degree such as PhD, Pharm D, MD or equivalent is preferred and +5 years directly related experience in a clinical development-biopharmaceutical environment, or the equivalent combination of education and experience.
- Demonstrated skills and understanding in Phase 1-3 clinical trial design and data interpretation; experience with oncology clinical trials is required.
- Knowledge of applicable FDA Code of Federal Regulations, Good Clinical Practices (GCP), ICH Guidelines, is required.
- Familiarity with the drug approval process through NDA or BLA or ex-US drug approval process is preferred.
- Sufficient content expertise and prior experience to be able to be a key contributor to document development such as INDs, Protocols, ICFs, IBs and regulatory submission package (NDA/MAA), under the direction and oversight of the VP, Clinical Development.
- Sufficient scientific knowledge and prior experience to play a lead role in the process of clinical study data review and interpretation.
- Proven track record of successfully delivering projects on time, to budget and the required quality.
- Excellent interpersonal, verbal and written communication skills.
- Team player, with the ability to move in a fast paced and dynamic environment.
- Ability to build and maintain effective internal and external professional relationships.
- Ability to travel approximately 25% of the time.
The anticipated salary range for this role is $160,000 – $200,000
To Apply:
Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.
Contact
California
9310 Athena Circle
Suite 300
La Jolla, CA 92037
USA
(347) 897-5988
Ontario
12 York Street
3rd Floor
Ottawa, ON K1N 5S6
CANADA
(613) 421-8930