Driving The Power of Innate and Adaptive Tumor Immunity

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

Turnstone is seeking a Research Associate to join our team of immunologists driving the development of our growing pipeline of T cell and oncolytic virus immunotherapies. This is an exciting opportunity to work along side senior researchers and project teams to perform discovery and development research that will ultimately create new medicines for cancer patients.

Turnstone’s T Cell therapy technology is based around a powerful new Selected-TIL process that revolutionizes the generation of tumour targeted T cells for adoptive cell therapy. Your role will be to work with a team of immunologists and molecular biologists to invent and develop these next gen T cell products for preclinical and clinical evaluation. There will be additional opportunities to continually refine the technology and manufacturing processes for this class defining therapy. If you have experience with T cell manipulation, engineering and culture, then this opportunity may be just what you are looking for.

You will work along side senior researchers and supporting technical colleagues within project teams at our state of the art facilities in San Diego and participate in designing and executing cell-based human immunology studies following established laboratory standard operating procedures (SOPs). We have an open, transparent and dynamic culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and grow your career right along with the company.

The Responsibilities include the following:

-Drive various aspects of in vitro and in vivo studies including but not limited to: designing and executing experiments, organizing teams, scheduling and managing complex multi-disciplinary experiments including data collection, analysis, and interpretation.

-Prepare data/figures to present to senior research staff

-Generate study reports in a timely manner

-Write and review SOPs

-Contribute to a team-centric culture that embraces scientific excellence, integrity, and urgency

Experience:

-Degree in Immunology/Microbiology/Biochemistry (research primarily focused in immunology) with recent biotech or pharmaceutical industry experience preferred

-Extensive experience with immune assays including flow cytometry, ELISA, ELISPOT, immune cell culture and common molecular techniques.

-Experience with T cell engineering is highly desirable

-Experience studying T cell metabolism and cell state is a plus

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

Turnstone’s T Cell therapy technology is based around an exciting new Selected-TIL process that revolutionizes the generation of tumour targeted T cells for adoptive cell therapy. Your role will be to join a team of immunologists and molecular biologists who invent and develop these next gen T cell products for preclinical and clinical evaluation. There will be additional opportunities to continually refine the technology and manufacturing processes for this class defining therapy. If you have experience with T cell manipulation, engineering and culture then this opportunity may be just what you are looking for.

You will work along side senior researchers and supporting technical colleagues within project teams at our state of the art facilities in San Diego and participate in designing and executing cell-based human immunology studies following established laboratory standard operating procedures (SOPs). We have an open, transparent and dynamic culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and grow your career right along with the company.

The Responsibilities include the following:

-Design and execution of in vitro and in vivo studies to understand T cell activity, function, cell state and phenotype from human and rodent tissues

-Participate individually or as part of project teams to schedule and manage complex multi-disciplinary experiments including data collection, analysis, and interpretation.

-Prepare data/figures and presentations to communicate results from experiments to senior research staff

-Generate study reports in a timely manner

-Write and review SOPs and overseeing training for team members

-Contribute to a team-centric culture that embraces scientific excellence, integrity, and urgency

Experience:

-Ph.D. in Immunology/Microbiology/Biochemistry (research primarily focused in immunology) with post graduate experience or and/or biotech or pharmaceutical industry experience

· This role will be positioned out of our new San Diego site

-Deep knowledge and experience in T cell function/differentiation/signaling/regulation, metabolism/phenotypic analysis of inhibitory and costimulatory targets and pathways and/or neoantigen biology and vaccines is highly preferred.

-Robust understanding of innate and adaptive immune systems is required

-An expert knowledge of immune based in vitro assays, flow cytometry and common molecular techniques such as cell based and biochemical assays to interrogate the immunological mileu of human blood tissue or tumour samples, including ICS, ELISpot assay, ELISA, RNA seq

-Experience with T cell engineering highly preferred

-Experience studying T cell metabolism and cell state highly preferred

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

This role will be responsible for elevating the Program Leadership/Project Management and Alliance Management functions to ensure creation of the program plans and budgets, as well as day-to-day planning, coordinating and tracking of critical activities. You will be responsible for providing critical Program/Project Management expertise and support to Turnstone Biologics internal programs and strategic partnerships to ensure all Program / Project milestones and deliverables are met, and that tasks are well managed and executed. You will also be responsible for driving the program timelines to keep them on schedule and within budget. Additional coordination responsibilities, as highlighted in more detail below, also include planning, facilitating, and following-up on regular program team meetings; anticipating and managing potential program issues; understanding the scope, schedule and resources for the program; utilization of Gantt charts and other project management tools to facilitate communication within the team, across the organization, and with external collaborators.

RESPONSIBILITIES

· Oversee internal program leadership, project management and alliance management
· Partner with the Program Leaders, project and alliance managers to optimize team effectiveness and decision making
· Coordinate the management of internal and external programs including project planning, progress tracking and budget planning & tracking
· Interface internally by acting as a liaison and facilitator of cross functional teams (i.e., Clinical Development, Clinical Operations, Technical Operations, Regulatory, Quality Assurance, Finance, etc.) in planning and executing trials
· Champion the development of the Program Leadership Department through introduction of new tools and processes for continuous improvement
· Sets key performance indicators and create timelines for driving internal and external programs on schedule.
· Facilitate highly effective team building and communication
· Proactively and independently, identifies and resolves program team challenges
· Perform effective risk management assessments with the Program Team, the Program Leader, and stakeholders
· Drive information flow and communicates program status to all stakeholders in collaboration with the Program Leaders and Project Managers.
· Coordinate production of regular status reports (milestones, status, issues, decisions), following review by the Program Leader and Program Team, for executive and senior management
· Coordinate portfolio reviews
· Support program knowledge management and data integrity procedures
· Partner with business development to initiate strategic relationships
· Manage and optimize the value of our strategic alliances across research, development and clinical
· Function as the internal and external point of contact for collaboration management and progress
· Support sponsored research contract execution
· Interface externally with collaborators, vendors, contractors, and consultants to ensure communication and deliverables in accordance with planned program objectives
· Identify platform, program and product issues
· Support regulatory filings
· Support setting of program strategy
· Support corporate financing initiatives
· Mentor and develops program leadership & management group members

Experience & Qualifications:

Minimum of a BA/BS is required, while an advanced degree (PharmD, PhD) is highly desirable.
· 10+ years of work experience, 8-10 years of Program/Project or Alliance Management experience, preferably within a matrixed pharmaceutical, biotechnology or medical device organization
· Extensive project planning experience required, especially an understanding of the clinical development and product commercialization processes. PM Certification is a plus
· Oncology experience is highly desirable.
· Advanced (gene or cell) therapy experience is highly desirable.
· Proactive mindset with strong formal and informal leadership, facilitation, teamwork and influence management/negotiation skills.
· Must have excellent verbal and written communication skills as well as exceptional organizational capability.
· Prior experience in leading and managing interdisciplinary or cross functional pharmaceutical or biotech teams is required.
· Ability to drive program plans and timelines (across multiple functional areas) is essential
· Proven success in goal setting, prioritization and time management is required
· Understanding of FDA and/or EMA quality and regulatory processes. Prior experience with regulatory filings is highly desired
· Experience working with external partners is highly desirable
· Experience actively participating in a steering committee or joint development committee for pharmaceutical, biotech, or medical device product development is highly desired
· Ability to work independently in decision-making and resolution of program obstacles and conflicts
· Familiarity with developing budgets and forecasting is desirable
· Keen insight, independent judgment and tactful discretion are required
· Must be able to demonstrate strong analytical and problem-solving capabilities
· Ability to function autonomously, with an appreciation of detail while being cognizant of “the big picture”
· Proficiency with Microsoft Word, Excel, PowerPoint, and Project is required.

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

The Research Technician provides support and assistance to senior researchers and project teams by performing a variety of experimental techniques using state-of-the-art instrumentation, and following established laboratory standard operating procedures (SOPs). The Research Technician is responsible for experimental laboratory duties such as: tissue culture; cell-based functional assays; ELISAs; qRT-PCR; Western blots; immunohistochemistry/immunofluorescence.

The candidate is expected to keep accurate experimental records and contribute to data analysis and figure preparation under supervision of senior research staff.

Additional responsibilities will include inventory management; laboratory organization; routine maintenance and calibration of laboratory equipment.
The incumbent will participate in an innovative research environment and will support a team working to translate basic research findings into novel therapeutic strategies. The position will contribute both intellectually and experimentally to the success of a multidisciplinary team.

Responsibilities:

• Prepare media and solutions
• Tissue culture: maintain primary cells and cell line cultures
• Perform Western and Southern blots
• PCR Analysis
• Assist lab members with various experiments
• Keep accurate experimental records
• Autoclave instruments
• Responsible for following Standardized Operating Protocol for lab tests
• Assist in the summation or analysis of data required for communications/reports/presentations.
• Perform a range of duties associated with maintaining laboratory readiness in cooperation with other team members
• Inventory management, i.e. order/unpack/restock/organize lab supplies as required
• laboratory equipment maintenance and operation
• Other duties as required

Experience & Qualifications:

• Undergraduate degree in science (BSc) or diploma with an acceptable combination of education and experience.
• 2-3 years’ experience in an academic or industrial laboratory preferred
• Must have good analytical and problem solving abilities with strong attention to detail
• Knowledge and experience with standard software (e.g. LIMS, Microsoft Office Suite, GraphPad Prism)
• Knowledge and commitment to Occupational Health and Safety Procedures and Biosafety Procedures in a laboratory.

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

The Director of Program Management will design appropriate program management plans and processes to support clear communication, decision making, prioritization and resource planning. Interact collaboratively with colleagues to ensure alignment on project action items, deliverables, and vision. Responsible for planning and execution of product development projects in the RIVAL portfolio. Plans and directs schedules and monitors budget/spending. Ensures consistent practices throughout all phases of the project life cycle. Drives the development and manages the execution of high quality, integrated cross-functional plans for projects. Applies project management best practices in the development, initiation, planning, execution, control and closing of projects. Provides clear direction on product development requirements to meet expectations of internal and external stakeholders. Interacts with research and development, manufacturing, clinical and regulatory departments and with external stakeholders. Responsible for project performance, risk management, administration, financial management and issue resolution for functional group.

• Ensuring that programs in the Research and Development portfolios are supported with appropriate and consistent Project/Program Management support, including:
o Facilitating the development of cross functional strategy and ensuring appropriate communication to internal stakeholders
o Defining program level plans that include scope, timelines, milestones, deliverables, key Go/NoGo decisions points, resources, and budgets
o Tracking and owning program timeline, milestone, and budget data
o Leading the team through planning for cross functional transitions
o Ensuring that changes to program timelines are appropriately communicated to the team and Leadership
o Coordinating team meetings as needed to meet team deliverables, track decisions and follow up on action items
o Working with the team to identify program risks and develop mitigation strategies
o Partnering with Program Team Leader to drive the team to clear and effective decision points.
• Ensuring that corporate alliances and/or academic collaborations are supported with Alliance management support, including:
o Facilitating joint team meetings at appropriate frequency to meet the needs of the team
o Ensuring internal team and leadership team is aware of and working towards meeting collaboration expectations
o Understanding Turnstone positions on strategic goals and ensuring appropriate communication to partner
o Ensuring team is meeting contractual obligations and flagging to leadership when contractual interpretation is required
• Maintaining close cross-departmental relationships to ensure that all critical parties are aware of project activities, issues and contingencies.
• Proactively, and independently, identifies and resolves program team challenges.
• Preparing information with appropriate input from program team members for internal as well as external partner review/governance meetings
• Developing and implementing communication tools that enhance information exchange within program teams and across functions
• Serving as an integral member of the program management function, ensuring cross-functional alignment of program strategies.
• Driving high performing, cross-functional teams to promote effective communication and ensure integration and alignment of internal subject matter experts via team meetings and program updates
• Performing effective risk management assessments with the Program Team, the Program Leader, and stakeholders
• Reviews and proposes revised program work plans to accommodate changes in technical, marketing, or business objectives
• Providing input along with other senior managers in establishment of strategic plans and objectives. Accountable for making final decisions on administrative or operational matters and ensuring operations effective achievement of objectives.
• Partnering with functional leaders to define project strategies and proactively identify and escalate risks, gaps and challenges, key dependencies and decisions points. Works with teams to develop scenarios and solve problems
• Tailoring program, approach and systems to small and rapidly growing organization.

Experience & Qualifications:

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth, we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Requirements:

• MSc or BSc Degree
• 8+ years experience in a project management role in a biotechnology or pharmaceutical company
• PMP Project Management Certificate preferred
• Experience with advanced therapeutics including virus- and cell-based therapies preferred
• Oncology experience is highly desirable
• Familiar with drug development process and a demonstrated understanding of the clinical development process
• Ability to foster business relationships with internal and external business partners.
• Proven ability to influence others to get things done without formal authority.
• Demonstrated ability to map out new business processes and improve existing processes
• Ability to facilitate, negotiate and communicate in cross-functional team environment to achieve overall project goals.
• Self-motivated, comfortable in fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities
• Effective communication, interpersonal skills, collaboration and negotiation skills
• Highly organized and efficient, close attention to details and able to orchestrate multiple projects simultaneously
• Able to represent and communicate project timelines/priorities at senior management meetings
• Proficiency in using Microsoft Office suite – Word, Excel, PowerPoint and Project.

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

This role is part of the Computational Sciences team parting with the Translational Medicine Biomarker team to build and utilize big-data platforms to analyze preclinical, translational, and clinical data. This is a hands-on technical role in which you will aggregate patient clinical data and biomarker data (bulk and single cell NGS and TCRseq, multiplexed flow cytometry, pathology, functional immunology, and proteomic data) to assist in the identification of relevant biomarkers as well as to generate hypotheses that will define and drive the next generation of oncology therapies.
The responsibilities for this role include:

• Manage and evolve global data platforms for clinical and multidimensional correlative data and integrate and analyze such data to understand and define predictive biomarkers, mechanisms of action, mechanism of resistance and disease selection so to drive our optimal clinical development as well as discovery efforts.
• Design and implement computational bioinformatic methodologies to analyze and interpret data from a wide variety of sources including clinical data, external literature, high throughput genomic data, multidimensional pathology data, flow cytometry, functional immune and proteomic data.
• Utilize APIs, data exploration and visualization tools as well as bioinformatics approaches to support discovery, pre-clinical and clinical studies including, but not limited to, informing new disease indications for our therapies, and developing predictive biomarkers
• Collaborate with domain experts in privacy, security, and compliance to ensure that the R&D data platforms uphold privacy, security, and compliance requirements

Experience & Qualifications:

• PhD or Master’s degree in bioinformatics, computer science, statistics, data science or a related field with a particular focus on data analysis.
• This role will be positioned out of either site in San Diego or Ottawa
• Willingness to travel (when it’s safe as it pertains to global pandemics) up to 10-30% to other Turnstone sites and/or external CMOs throughout North America (USA, Canada) and Europe
• First-hand experience using patient clinical and biomarker data (proteomic, flow cytometry, pathology and genomic data-bulk and single cell NGS) in concert with preclinical and public NGS data to develop and support disease selection and biomarker strategies
• 5 years of experience in life sciences, pharma or informatics industry working with clinical trials data, genomics, and biomarker data is preferred.
• 5 years of hands-on experience of applying data science methods and tools to diverse problems using R and/or Python is preferred.
• Expert programmer in at least one language, with experience working in production environments.
• Experience with statistical analysis, bioinformatics/genomics tools (such as GATK, BEDtools, VCFtools, STAR aligner, DEseq, etc.), data visualization, and databases
• Working understanding of innate and adaptive immune systems is preferred
• Experience with data analysis – RNA-Seq, single cell analysis, flow cytometry, variant calling
• Experience with existing and upcoming machine learning methods (supervised and unsupervised) in pharmaceutical data analysis
• Collaborative development skills using version control systems (e.g., Git)
• Familiarity with using virtualized working environments such as Docker
• Proven ability to work in a matrix environment is preferred
• Comfortable in a dynamic environment with competing priorities
• Strong communication both written and spoken
• Strong interpersonal skills and a communication style that matches the Turnstone style: respectful, transparent, and constant

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

In this role, you will have the opportunity to develop your ability to think strategically and drive fast-paced execution. With our company size and growth, we will give you plenty of opportunities for you to be an inspirational and collaborative functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

This role will lead the development of data platforms to analyze preclinical, manufacturing and clinical data. You will lead the aggregation and analysis of multiple data types including bulk and single cell genome and transcript sequence data, multiplexed flow cytometry, proteomics, pathology, functional immunology, and manufacturing data. You will help define mechanisms of action, manufacturing optimization strategies and product portfolio development and selection as well as to generate hypotheses that will define and drive the next generation of oncology therapies.

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company. Turnstone is based in Ottawa, Canada, and San Deigo, USA. This role can be associated with either site, or remote, assuming flexibility to travel between sites as required.

The Responsibilities of the role include:

• Supervise and mentor all company bioinformatics/computational biology/machine learning staff to generate biological insights.
• Lead end-to-end analyses that include tool development, processing, analysis, iteration with partners, and presentation of results
• Design, execute, and own computationally efficient software solutions to analyze large, complex genomics datasets using machine learning and statistical methods
• Investigate the biology of tumor-reactive T cells, nucleic acid in cancer, generate statistically secure findings, and relate them to performance and clinical value of novel gene and cellular therapies
• Interact cross-functionally and work closely with interdisciplinary teams including research, clinical, product development, laboratory operations, and external collaborators
• Lead cross-functional collaborations between informatics team and other R&D and GMP manufacturing functions and teams
• Work with company executive leadership to formulate and translate corporate strategy and priorities into concrete informatics projects and deliverables
• Represent company externally in informatics in business development activities and industry conferences
• Stay abreast of industry and academic developments in the statistical genomics and real-world evidence generation and apply to translational study design and analysis

Requirements

• Ph.D. (or MSc + with at least 8 years) in Bioinformatics, Computational Biology, Statistics, Biological Sciences, Cancer Biology, Genetics, Genomics, Computer Science, Physics, or equivalent preparation and experience.
• This role will be positioned out of either site in San Diego or Ottawa
• Willingness to travel (when it’s safe as it pertains to global pandemics) up to 25% to other Turnstone sites
• Proven track record of strong contributions demonstrated by highly cited publications, impactful tools, products, or data sets used by the scientific community and presentations at international conferences.
• Track record of significant scientific contribution to successful drug or diagnostic development programs
• Deep expertise in cancer genomics
• Extensive experience in molecular biology and NGS assay development and automation
• Experience with Illumina NGS workflows including library construction, hybrid capture enrichment, or amplicon-based sequencing
• Lead authorship roles on high-impact publications
• Experience with commercial deployment of AWS services and scale up/out of genomics analysis.
• Experience leading informatics in the FDA regulated / GMP manufacturing setting
• Able to work effectively in a fast-paced, small biotech environment
• Strategic agility and strong critical and logical thinking
• Willingness to roll-up sleeves and pitch in to help team hit milestones
• Strong ability to prioritize, multi-task, and work in an evolving environment
• Excellent presentation and written/verbal communication skills
• Contribute to building a culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

This role will build and utilize big-data platforms to analyze preclinical, manufacturing and clinical data. This is a hands-on technical role in which you will aggregate and analyze multiple data types including bulk and single cell genome and transcript sequence data, multiplexed flow cytometry, proteomics, pathology, functional immunology, and manufacturing data. You will help define mechanisms of action, manufacturing optimization strategies and product portfolio development and selection as well as to generate hypotheses that will define and drive the next generation of oncology therapies.
We are in the early stages of building strategies, structures and process so this role will be busy and expanding. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The responsibilities of this role include:

• Model and analyze large, complex genomics datasets using machine learning and statistical methods to generate biological insights.
• Support cross-functional collaborations between informatics team and other R&D and GMP manufacturing functions and teams.
• Create and/or operate computational approaches and analytical tools or customize existing applications (as required) to interrogate immune cell quantity, function and phenotype within the tumor microenvironment.
• Investigate the biology of tumor-reactive T cells, nucleic acid in cancer, generate statistically secure findings, and relate them to performance and clinical value of novel gene and cellular therapies.
• Consult within research and cross-functionally to analyze problems, recommend informatics-based solutions, or determine computational strategies.
• Work closely with interdisciplinary teams including research, clinical, product development, laboratory operations, and external collaborators.
• Represent company externally in informatics and industry conferences.
• Stay abreast of industry and academic developments in biological computational science.
• Generate, interpret and communicate knowledge from gene expression profiles, genome annotation, TCR sequencing and single cell RNA sequencing data.
• Manipulate publicly accessible, commercial, or proprietary genomic, proteomic, or post-genomic databases.
• Improve user interfaces to bioinformatics software and databases.
• Instruct others in the selection and use of optimal and appropriate bioinformatics tools
• Review professional literature to maintain professional knowledge.
• Contribute to building a culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.

Requirements

• Ph.D. (or MSc + at least 3 years) in Bioinformatics, Computational Biology, Statistics, Biological Sciences, Cancer Biology, Genetics, Genomics, Computer Science, Physics, or equivalent preparation and experience.
• This role will be positioned out of either site in San Diego or Ottawa
• Willingness to travel (when it’s safe as it pertains to global pandemics) up to 25% to other Turnstone sites
• Proven track record of strong contributions demonstrated by highly cited publications, impactful tools, products, or data sets used by the scientific community, presentations at international conferences, and awards.
• Deep expertise in cancer genomics
• Track record of scientific contributions to successful drug or diagnostic development programs
• Experience with NGS software workflows and analysis of single cell, whole exome, or targeted NGS sequencing data (DNA and RNA) on Illumina HiSeq/MiSeq sequencers
• Experience with Illumina NGS workflows including library construction, hybrid capture enrichment, or amplicon-based sequencing
• Collaborative development skills using version control systems (e.g., Git)
• Familiarity with using virtualized working environments such as Docker
• Experience working in the cloud (AWS), on a Linux based high-performance computing cluster, and contributing to shared code bases is desirable
• Proficiency with statistical analysis in R or Python, and data visualization highly desirable
• Experience with ELN and LIMS systems is desirable
• Working knowledge of RNA-Seq, flow cytometry, variant calling, single cell genomics analysis is preferred
• Lead authorship roles on high-impact publications is desirable
• Experience in supporting informatics in the FDA regulated / GMP manufacturing setting is desirable
• Working understanding of innate and adaptive immune systems is preferred
• Able to work effectively in a fast-paced, small biotech environment
• Willingness to roll-up sleeves and pitch in to help team hit milestones
• Strong ability to prioritize, multi-task, and work in an evolving environment
• Excellent presentation and written / verbal communication skills
• Strong interpersonal skills and a communication style that matches the Turnstone style: respectful, transparent, and constant

To Apply:
Please click here to apply!

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

The Research Associate or Senior Associate, in this individual contributor, lab-based role, will work in a collaborative environment to perform Analytical testing and development to support Turnstone’s TIL cell therapy development programs. This position will join the development group and work with the analytical testing group that values data quality, high productivity and teamwork. The key deliverables for this role are precise, accurate, and high-quality data presented, communicated, and integrated in an effective manner. This position will require thorough documentation of all experimental steps and final data readout.

Responsibilities:

• Execution of key analytical methods such as multi-parameter flow cytometry, bioassays and qPCR-based methods and data analysis in support of process development activities, product characterization, and raw materials testing.
• Provide support to other groups for assay development, qualification, and transfer into Analytical Development
• Developing processes and methods to improve lab execution and data analysis
• Timely and thorough documentation and completion of electronic laboratory notebooks
• Author reports detailing experimental work and summarizing results
• Contribute to an overall high-performing laboratory, with a willingness to contribute in all ways, such as ordering, tracking, and maintaining inventory of lab supplies and reagents

Experience & Qualifications:

• BS in a scientific discipline 2+ yrs experience (1+yrs with MS) of relevant industrial experience. Final role can be commensurate with relevant industry experience.
• Experience with flow cytometry or cell-based bioassays, ELISA, and PCR techniques
• Experience with aseptic cell culture and cell-based assays.
• Ability to follow laboratory procedures with attention to detail, and successfully execute experiments at the bench.
• Experience with other techniques in molecular biology, such as RT-PCR is preferred
• Previous experience with cell therapy products is preferred
• Demonstrated ability to effectively work in cross functional teams, meet deadlines, and prioritize multiple projects
• Experience working in a self-driven, performance/results oriented, fast paced matrix environment
• Working knowledge of statistical software (R, JMP, Minitab) is preferred.

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

As an Engineer or Sr. Engineer (depending on your relevant experiences and expertise), you will provide process development and engineering support for process design, characterization, and improvements with a goal of ultimately enabling GMP manufacturing. Primary responsibility will be to design, lead, and execute experiments that contribute to development and characterization of the TIL cell therapy manufacturing process. Experiments will be performed to identify and define Critical Process Parameters and process ranges. Additionally, you will draft and review study plans and reports, analyze and trend process data, perform Design of Experiments (DoEs), and provide technical support for manufacturing sciences, technology, and process changes. Turnstone works in a highly cross-functional environment, so your contributions will be critical for our pre-clinical, clinical, and regulatory workflows, with an opportunity to engage and enable your colleagues across the business.

Responsibilities:

• Develop manufacturing processes for cell therapy products and develop process improvements and efficiencies
• Lead and execute laboratory studies to support process design and development, characterization and process improvements
• Write and review technical documentation
• Participate and report to a cross-functional development team to advance production activities
• Assist in technology transfer to GMP manufacturing by generating development reports and providing on-site technical support.
• Authoring and assistance in the technical review of supporting documents, reports, including CMC sections for regulatory filings.
• This is a hands-on position requiring conducting laboratory experiments, good documentation review skills, good writing skills, and the flexibility to move between the management and execution of each required function as needed.
• Act as technical expert to train and supervise process technicians

Experience & Qualifications:

• Minimum of 3 years of relevant industry experience, with role flexibility available commensurate with experience
• Degree in Biochemical Engineering, Chemical Engineering, Biomedical Engineering, Biotechnology or related discipline with pharmaceutical/biotech manufacturing & process development experience required
• Fluency with cGMP manufacturing and regulatory regulations and requirements for pharmaceuticals and devices
• Cell culture and aseptic processing experience
• Working knowledge of scientific and engineering principles
• Experience in statistical analysis using JMP or Minitab
• Practical experience in GMP operations
• Ability to function efficiently and independently in a changing environment
• Self-motivated and willing to accept temporary responsibilities outside of initial job description
• Excellent interpersonal, verbal and written communication skills are essential in this collaborative work environment
• Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities
• The primary location of the position is San Diego, but may be required to travel, based on business priorities

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

This is an opportunity to build the Cell Therapy Manufacturing team in partnership with Tech Ops Leadership. We are growing quickly and establishing our work flows and practices to ensure operational excellence, fitfor-purpose, at every stage of development. As a core team within TechOps, this team is responsible for the GMP manufacturing of our TIDAL cell therapy products: cutting-edge autologous TIL products for underserved solid cancers. To support this goal, the team will also oversee all unit operations, from molecular diagnostics to peptide chemistry to TIL expansion at our global network of contract manufacturing organizations, and be pivotal in exploring when, how, and to what degree internalization of manufacturing operations should occur.

The ultimate goal is to have manufacturing leadership, infrastructure, and expertise such that we remain in full control of our own destiny. The team will work closely with the cell therapy development team to support tech transfers to GMP partners, capturing process knowledge and ensuring a smooth transition. As the Director of the Cell Therapy Manufacturing team, you will report to the Senior Director of CMC and QC (core member of TechOps Leadership Team reporting to the Chief Technology Officer, member of the executive team).

The responsibilities for this role include:

– Establishing workflows, SOPs, and practices for manufacturing operations at external CMO partners

– Growing, hiring, coaching, mentoring, and developing the Cell Therapy Manufacturing team to meet the evolving clinical needs

– Leading cell therapy manufacturing campaigns with external CMO partners, serving as the principal external facing leader of Turnstone cell therapy manufacturing operations

– Support manufacturing batch readiness including process definition, raw material procurement, and batch documentation preparation and/or revision

– Support ongoing batch monitoring including person-in-plant coverage

– Participate in cross functional teams troubleshooting and lead deviation investigations with ongoing manufacturing runs, in very close partnership with the cell therapy development team and R&D

– Lead autologous product manufacturing campaign closeout including the review of executed batch records and shipping/logistics of finished material

– Support process development, engineering runs, and other process scale-up related studies

– Lead the identification and selection of new external CMO partners

– Lead manufacturing sciences, building a robust approach for process data collection, analysis, and interpretation

– Influence and contribute to the development of Turnstone’s cell therapy manufacturing strategy and roadmap, informing key decisions around external CDMO supply network vs. internal manufacturing capabilities/infrastructure.

– Serve as a key member of the Extended TechOps Leadership Team, aiming to develop the next generation of talent amongst our scientific and engineering leaders, and group leaders.

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth, we will give you plenty of opportunities for you to be an inspirational and collaborative leader. Passionate about being a part of a critical function of a growing company and continuous learning? You will be engaged in building a team and a workflow that plays a critical role in getting cutting edge therapies to people suffering from cancer.

We are in the early stages of building strategies, structures, and processes so this role will be busy and expanding. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience & Qualifications:

• This role will be formally positioned out of San Diego, California or Ottawa, Canada

• Willingness to travel (when it’s safe as it pertains to global pandemics) up to 10-30% to other Turnstone sites and/or external CMOs throughout North America (USA, Canada) and Europe

• MSc or PhD in Cell Biology, Immunology, Chemical Engineering, Biomedical Engineering or a related scientific discipline

• 7-10 years of relevant experience in a manufacturing operation, manufacturing sciences and technology, or manufacturing technical support role

• Experience with the manufacturing and operational complexity of cell therapy-based therapeutics such as TIL, CAR-T, TCR, or stem cell products, especially experience with autologous therapies is considered very important

• Understanding of aseptic manufacturing processes and related risk assessments and mitigation strategies

• A depth of understanding of current good manufacturing practices (GMP) in an early clinical to late phase clinical manufacturing setting is important, with commercialization experience as a bonus

• Experience managing external relationships such as CMO partners or clients as a CMO provider and a mature and thoughtful communication approach to support strong partnerships

• Comfortable leading a cross-functional team in time sensitive, high pressure, and high-risk situations (e.g. manufacturing issue resolution)

• Experience leading, developing, and coaching a team of direct reports, while also building a team from the ground up

• Comfortable in a dynamic environment with competing priorities

• Strong technical writing skills

• Strong communication both written and spoken

• Strong interpersonal skills and a communication style that matches the Turnstone style: respectful, transparent, and constant

• Excellent computer skills, including Microsoft Excel and PowerPoint

• Strong data analysis skills, with familiarity with JMP or similar data analysis tools

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth, we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Our Virus Manufacturing (VMFG) team is growing. As part of the Technical Operations organization, the VMFG team is responsible for the GMP manufacture of Cell Banks, Virus Banks, Drug Substance and Drug Product for our clinical-stage assets. VMFG supports technology transfers and collaborates closely with the Virus Development & Manufacturing Sciences team to develop and capture process knowledge and ensure overall manufacturing success. As an Associate Engineer of Virus Manufacturing on the VMFG team, you will be tasked with supporting manufacturing campaigns from end-to-end within our external contract manufacturing organization (CMO) network.

The responsibilities for this position span across our multi-modal platform and include:

– Support virus manufacturing campaigns with external CMO partners
– Support virus manufacturing batch readiness including process definition, raw material procurement, and batch documentation preparation
– Support ongoing batch monitoring including person-in-plant coverage
– Support cross functional teams troubleshooting and resolving issues with ongoing manufacturing runs
– Support virus manufacturing campaign closeout including the review of executed batch records and shipping/logistics of finished material
– Support process development, engineering runs, and other process scale-up related studies
– Support the identification and selection of new external CMO partners
– Support drafting of regulatory documentation including INDs, CTAs, etc.
– Represent the Virus MFG team at Technical Operations cross-functional program meetings

Experience & Qualifications:

• This Associate Engineer role will be formally positioned out of our Ottawa, Canada office
• Willingness to travel (when it’s safe as it pertains to global pandemic) up to 10-30% to other Turnstone sites and/or external CMOs throughout North America (USA, Canada) and Europe
• BSc in a science, engineering, or biotechnology related discipline; MSc considered an asset
• 1-3 years’ experience in a technical operations or research/development role
• Experience with live virus based therapeutic manufacturing such as viral immunotherapies, vaccines, cell and gene therapies, or other complex biologics
• Experience with good manufacturing practices (GMP) in a clinical or commercial manufacturing setting
• Experience with the qualification and operational use of single use, small scale mammalian cell culture, tangential flow filtration, and/or chromatography-based purification equipment and raw materials
• Comfortable in a dynamic environment with competing priorities
• Strong technical writing skills
• Teamwork – willingness to lead and willingness to be lead when it’s appropriate
• Positive Attitude – interest in learning how to adapt to fast-growing teams and a dynamic virtual working environment
• Communication – interest in learning how to communicate effectively cross functionally with multiple levels in the organization and externally to global partners
• Growth mindset – constant approach of challenging oneself to learn more, learn faster, and learn better
• Excellent computer skills, including Microsoft Excel and PowerPoint

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

As the Sr. Engineer/Sr. Scientist of upstream process development, you will report to the Head of Drug Substance Process Development. As part of this role, you will lead all of the technical aspects of our virus process development program across cell line, media/feed strategies, infection/harvest and bioreactor scale up and development. You will be a critical member of our Process Development team and help contribute to the overall strategy and execution of our virus CMC and translation. Specifically, you will:

· Develop the upstream process development targets and strategy to reach our program needs across a suite of virus-based drug products
· Contribute as the subject matter expert to the overall upstream process development of our virus pipeline supporting cell line development, media development, feed strategy development, infection and harvest conditions, and bioreactor scale up
· Lead interactions with our external CDMO network to accomplish efficient process development advancement
· Collaborate with Drug Product development, Manufacturing Sciences and Manufacturing Operations to support smooth translation of processes through inception to clinical manufacturing
· Participate in technology transfer of our processes to local and international GMP partners
· Support Manufacturing Sciences team with scale-up of the manufacturing processes, and deviation investigations
· Employ QbD principals to perform process characterization studies
· Act as subject matter expert for review of data in regulatory filings

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size (approximately 100 team members, and growing fast!) we will give you plenty of opportunities to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience

Turnstone Technical Operations is a virtual organization, where the majority of our wetbench work is executed at third party CMO/CRO partners. We have offices in Ottawa, Canada and San Diego, USA and this role would ideally inspire you to relocate. Most of our virus development team is stationed in Ottawa and most of our partnerships are in Europe – therefore being in Ottawa would be ideal, but if you believe you can be successful in San Diego, we would love to speak with you! This role is best suited for someone with the following:

· Scientist or Engineer with advanced degree in Biochemical Engineering, Biotechnology or in other related Science field (virology, biology, biochemistry, protein chemistry, pharmaceutical chemistry)
· 5-7 years of experience in upstream process development within biotech/pharma
· Experience with process scale up, deployment and technology transfer of complex biological processes in a GMP manufacturing environment, and process qualification/validation are strongly preferred
· Proven expertise and technical depth in upstream process development (mammalian cell culture expression systems, ideally for the manufacture of live-viruses) is required
· Experience with media and feed development strategies
· Expertise in microcarrier, and aseptic process experience, is strongly preferred
· Experience leading bioreactor development workstreams and support scale up from benchm, to pilot, to GMP scale SUB
· Excellent communication skills with the proven ability to build open and collaborative relationships, work effectively as a member of a multidisciplinary team
· Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency, and function effectively in a fast-paced and dynamic environment
· The candidate must exude a mature communication style that matches the Turnstone style: respectful, transparent, with a high degree of integrity and humility
· Able to manage competing priorities effectively and adapt to changing priorities
· Analytical and quantitative approach to problem solving, with the ability to self-start and independently investigate technically challenging problems
· Excellent computer skills, including JMP, Microsoft Excel, Powerpoint and Word

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

As the Associate Director of Formulation and Drug Product Development, you will provide leadership to a team of Scientists, drive the strategic development plan and direct all Drug Product (DP) and formulation development efforts to support our viral-based platforms (RIVAL). Reporting to the head of viral development, you will:

· Participate as an active member of the Viral Development leadership team, to support overall analytical and process development needs across Drug Substance and Drug Product development
· Manage a cross-functional matrix team (Clinical, Supply Chain, Regulatory, Quality, Tech Ops) to develop overall Drug Product development strategy for a suite of viral-based products
· Provide leadership and guidance to a small team of Scientists
· Drive development of improved viral delivery systems (IV infusion, IT or IM injections) to enable optimization of pharmacy DP handling and administration
· Develop and drive the overall stability program strategy at all key stages of manufacture
· Work closely with the Analytical Development team to ensure appropriate and robust assays are in place to enable stability assessments, and drug product characterization
· Lead all aspects of pre-formulation and formulation development across a range of DP images (liquid, and lyophilization)
· Drive to definition of DP critical quality attributes through forced degradation studies and advanced analytical tools
· Support biophysical analytical development and design of characterization studies
· Participation in regulatory strategy and document authoring/reviewing for interactions with FDA, EMA, Health Canada, MFDS, and other jurisdiction as they emerge

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience & Qualifications:

Turnstone Technical Operations is a virtual organization, where nearly all of our wetbench work is executed at third party CMO/CRO partners. We have offices in Ottawa, Canada and San Diego, USA and ideally you feel motivated to relocate for this role to one of those sites. Most of our virus development team is stationed in Ottawa Canada, and most of our partnerships are in Europe – therefore relocating to Ottawa would be ideal, but if you feel you can be successful from San Diego, then let’s chat! This role is best suited for someone with the following:

· 8-10 years of overall experience within the biotech/pharmaceutical industry
· Minimum of 3 years of leadership experience demonstrated as either having direct reports, and/or demonstrated leadership across complex projects and cross functional teams
· Scientist with advanced degree (PhD strongly preferred but not required)
· Strong interpersonal skills required
· Experience developing and/or interpreting biophysical analytical methods
· Expertise developing novel formulations (experience developing live virus formulations considered a very strong asset)
· Experience working with drug transfer devices and planning pharmacy handling procedures
· Expertise managing stability programs, including knowledge of relevant regulatory guidances, considered a strong asset
· Educated in one of the following fields: Biochemical Engineering, Biological/Biomedical Engineering, Virology, Biology, or Biochemistry
· Experience designing, and planning accelerated studies to evaluate degradation pathways and define CQAs
· Excellent computer skills, including Microsoft Excel and Powerpoint
· Able to manage competing priorities effectively and adapt to changing priorities
· Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency, and function effectively in a fast-paced and dynamic environment
· The candidate must exude a mature communication style that matches the Turnstone style: respectful, transparent, with a high degree of integrity and humility

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics (“Turnstone”), a privately held clinical stage biotech company, is developing breakthrough cancer immunotherapies by advancing two leading and complementary platforms that drive innate and adaptive tumor immunity, to provide benefit to the millions of cancer patients underserved by current treatment options. Turnstone’s proprietary vaccinia virus platform is engineered to drive coordinated immune activation, potent viral activity, and local expression of encoded therapeutics. The innovative TIL cell therapy platform leverages clinically validated treatment protocols and has been specifically designed to extend beyond the use of bulk TILs to enrich for the most relevant T-cells for tumor eradication, preserving broad antigen diversity and minimizing time to treatment for patients. The Company has an ongoing Phase 1/2a trial in solid tumors (RAPTOR) for its leading oncolytic virus candidate, RIVAL-01, and is expecting to file an IND for the lead TIL therapy candidate, TIDAL-01, in 2021.

At Turnstone, the science drives decision making and our therapeutics are designed with the patient foremost in mind. We continue to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding thereafter are what we call ‘another day at Turnstone’? If you are a passionate person, and our science excites you – this opportunity may be for you.

Position Overview:

Reporting to the Chief Financial Officer, this role will be responsible for managing the global accounting and finance function of Turnstone Biologics Corp. The Controller will oversee general and technical accounting, budget and forecasting management, tax operations and planning, equity administration, and, in the event the company undertakes an initial public offering of its securities, SEC reporting and compliance. The position will be directly involved with some or all the following.

Responsibilities:

Accounting and Controls

· Develop accounting and reporting systems and policies to ensure compliance with generally accepted accounting principles. Oversee timely and efficient monthly and quarterly closing and reporting process. On transition to a public company, ensure accurate and timely SEC filings (10-K, 10-Q, 8-K)

· Lead the annual audit process, prepare all supporting information for the annual audit. Develop strong partnership with external auditors to ensure clean audit sign offs and efficient quarterly reviews

· Consult with appropriate resources to ensure that new accounting guidance are analyzed and understood from an accounting standpoint. Communicate impact of technical accounting matters to executive management as necessary.

· Own and drive efficient and effective delivery of accounting services across Turnstone, to include general accounting, account receivables, payables and payroll. Collaborate with IT to drive development of appropriate financial systems to support accounting operations.

· Partner with legal and business development on contractual terms to assess financial and accounting impact and oversee financial compliance with all significant contractual obligations

· Help lead fundraising and financing efforts, working closely with the executive team. Help manage ongoing relationships with financial institutions.

· Prepare and present financials to the company, Board Audit Committee and key stakeholders.

· Develop, implement and monitor internal controls and financial policies and procedures to ensure that the organization’s day-to-day operational activities are efficient and effective, and investments are in-line with budgets.

Financial Planning & Analysis

· Lead all aspects of financial planning, budgeting and forecasting. Work closely with business partners and the executive team to plan for key revenue and cost drivers.

· Develop annual budgets for the review and approval of Management and the Board of Directors; ensure that input is provided by Project Managers in the development of budgets and forecasts.

· Prepare and provide quarterly detailed financial reporting packages (budget/cash flow forecasting/variance analysis) to Management, the Board of Directors and Investors of the organization

· Develop the financial reporting infrastructure (e.g., program and function P&Ls) to enable strategic decisions, ongoing analysis and performance tracking by the executive team

Tax and Treasury

· Manage global tax compliance with all required federal, state, local, payroll, property and other applicable taxes. Ensure that the organization makes all required government remittances and remits applicable taxes in which it operates

· Oversee cash management and act as the company’s treasurer

· Manage stock plan administration activities

· Assist with the management of business insurance requirements

Experience & Qualifications:

Qualifications:

· Undergraduate degree in business administration, accounting, finance, economics or related field is required; CPA required

· 15 years or more experience with progressively increasing responsibilities and leadership roles with significant experience in Accounting function

· Life science experience is required

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.