Cancer Immunotherapy
Re-Engineered

Intern: Process Development and Manufacturing Sciences

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another day at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being a part of a growing Process Development team, then this role may be for you! As an Intern, you will report to the Formulation Manager within the Bioprocess Development and Manufacturing Sciences team. With responsibilities spanning across our multi-virus platform, key duties as they relate to this role will include:

• Tracking and coordinating testing with various collaborators/partners
• Liaise with Projet Management and logistical team to ensure sample shipments are coordinated
• Manage incoming data for the process development team
• Analyze data by trending, and graphing
• Prepare presentations of data for discussion at group meetings
• Support design and execution of formulation studies which require knowledge of various characterization methods.

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportinites for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience & Qualifications:

This role is best suited for someone with the following:
• Masters’s or PhD degree in Science /Biology
• 1-2 years of overall experience within the biotech/pharmaceutical industry considered an asset
• Trained in one of the following fields: biology, biochemistry, or virology
• Basic knowledge of cell biology, and virology
• Excellent computer skills, including Microsoft Excell, Powerpoint, and Jmp
• Excellent data analysis capabilities including statistical methods
• Enjoy data mining, trending, and graphing data for presentation within reports or at meetings
• Excellent written communication skills to enable drafting of reports, and risk assessments
• Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency and function effectively in a fast-paced and dynamic environment
• Ability to multi-task and manage several competing priorities
• Attention to detail and highly organized

To Apply:

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another day at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being a part of a growing Technical Operations team, then this role may be for you! As the Director, Quality Assurance, you will oversee the Quality function to ensure GXP compliance in accordance with country regulations and guidelines, as well as the company’s policies and procedures.

The responsibilities include the following:

Drive the development of the company’s Quality strategy and policies.
Oversee company-wide documentation practices, record keeping, training, auditing, raw material qualification and risk assessment, SOPs, batch records, study protocols, reports, investigations, analytical methods, and release specifications.
Lead all QA efforts and documentation for the compliant manufacturing of lead product candidates.
Provide Quality Assurance and compliance oversight for contract manufacturers and research organizations to ensure products/deliverables meet all required quality standards and specifications.
Draft, review, and approve relevant sections of regulatory filings.
Build and scale the QA team to align with business objectives
Represent QA department at project and leadership team meetings.
Drive corporate and department objectives to completion through strong collaboration with a broad range of internal and external functions and levels of management
Cultivate a culture of quality and shared accountability throughout the organization to help ensure compliance with applicable regulations, guidelines, and corporate standards, policies and procedures.
Ensure that the company and its contactors (e.g., CMOs, clinical sites) are prepared for state, regional, or country authority inspections. Coordinate all authority inspections by ensuring sufficient resources are in-place to respond to information requests, adjudicate compliance discussions, and negotiate any required corrective actions.

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportinites for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience & Qualifications:

BA/BS Degree
Minimum of 10 years of operational quality assurance and GxP compliance. Requires manufacturing experience in a pharma or biotech environment, preferably focused in viruses or vaccines, gene or cell therapy.
Prior experience implementing quality systems and advancing novel therapeutics from preclinical stages through IND to BLA is desired.
Effectively managed FDA inspections/audits, and conducted supplier/manufacturer audits.
Demonstrated ability to manage staff and projects (direct and indirectly) and variable workloads with demanding timelines.
Ability to build/scale Quality functions.
Strong interpersonal, teamwork, and organizational skills; effective oral and written communication skills.

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another day at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

Our Bioprocess Development and Manufacturing Sciences (PD&MS) team within the overall Technical Operations department is growing. As an Associate Scientist on the PD&MS team, you will report to the Process Development Engineer responsible for leading all of the upstream process development activities, like cell line and media development, optimization of cell culture, bioreactor engineering and virus manufacturing. The responsibilities for this position span across our multi-virus platform and include:

· Study design, planning and implementation to drive process development activities to include protocol design, data analysis, and report writing.
· Building and maintaining data-rich batch analysis to enable data interpretation and ongoing trending
· Communicating study findings at internal Technical Operations meetings, and to external stakeholders via powerpoint presentation of the analyzed data
· Technology transfer of process development successes to larger scale and GMP
· Cell line and cell train development to fit to new bioreactors, reduce the use of animal-derived additives, and enable high virus productivity from cells
· Optimize virus infection and harvest conditions to ensure maximum productivity per cell
· Building and utilizing process engineering knowledge and analyzing processes to identify areas for improvement
· Conduct research on literature, new technologies and process data to offer insight and direction with regards to upstream process development approaches and findings

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportinites for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience & Qualifications:

The Associate Scientist will be positioned in our Ottawa, Canada office Head Quarters
A Bachelor’s of Science (BSc) and Master’s degree in one of these related fields: virology, biochemistry, or molecular biology (PhD considered an aasset)
Virology focused post-graduate degree highly desirable
Strong knowledge of virology, mammalian cell culture, viral molecular biology and/or virus processing/manufacture is required
3+ years of experience post-education working in Industry, academia, or research laboratory
Experienced and confident in presenting data to key stakeholders and external partners
Innovative thinker with a proven track record of designing complex yet targeted experiments to answer key questions
Analytical minded individual with the ability to investigate technically challenging problems
Mature interpersonal skills and a communication style that matches the Turnstone style: respectful, transparent, and constant
Excellent computer skills, including Microsoft Excel and Powerpoint
Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency and function effectively in a fast-paced and dynamic environment
Able to manage competing priorities effectively and adapt to changing priorities

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being a part of a growing Analytical Development & Quality Control team, then this role may be for you! As an Associate Scientist, Analytical Development, you will be responsible for designing, developing, and qualifying assays to support any number of functions within the technical operations scope:  process development, formulation development, product characterization, raw material testing, and GMP product release and stability testing.  You will regularly interact with other Turnstone team members to establish needs, help with result analysis, and transfer well-established analytical methods. Your role will be to work directly with the lead Scientist for Analytical Development of cellular biology assays.  This role will involve some wet bench work to troubleshoot and optimize assays, through well-thought out experiments.  You will have experience working with some or all the following, as they relate to the Associate Scientist, Analytical Development duties:

• Designing and executing experiments precisely and carefully to drive development and optimization activities for cellular assays
• Developing and/or qualifying analytical assays suitable for characterization, in-process testing, final drug-product release, and/or product stability
• In-depth experience with various cellular methods such as:  plaque assay and TCID50s, ELISA, Western blot, Bradford assay, viral killing potency assay, etc
• Trending analytical metrics to confirm method reproducibility and consistency.  Experience with meta-analysis an asset
• Writing and reviewing protocols and reports describing analytical assays contributing to regulatory filings
• Transferring methods to other internal or external partners and supporting the collaboration through timely result analysis
• Communicating analytical results in a timely manner and collaborating with internal and external development teams to support their goals and timelines
• Managing multiple tasks and changing priorities in a fast-paced environment
• Communicating effectively to peers and leadership to support decision-making, including writing protocols and summarizing results in a report or presentation.

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution.  With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader.  Passionate about being a part of a critical function of a growing company and continuous learning?  We will have plenty of that for you!

We are in the early stages of building strategies, structures, and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The Details

This role is best suited for someone with the following:

• 2+ years of overall experience within the biotech/pharmaceutical industry in a laboratory setting performing cellular biology methods
• Proven ability to apply advanced analysis principles, theories, and concepts to solving complex problems associated with drug development
• In depth experience in a variety of cGMP laboratory activities and analytical techniques applied to the testing of viral-based products
• Strong ability to critically review, evaluate, and interpret analytical results (including stability data) and support investigations to resolve analytical issues
• Working knowledge of GMP regulations and FDA guidance applicable to biologics and immuno-therapy manufacturing
• Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency and function effectively in a fast-paced and dynamic environment
• Strong organizational skills to prioritize and manage multiple time-sensitive projects simultaneously
• A self-starting attitude: you work independently and effectively, with little oversight or management
• Advanced degree (M.S., Ph.D.) in cellular biology or related discipline
• Experience working in a fast-growing start-up environment strongly preferred

This role will be based in Ottawa, Ontario.

To Apply: Please click here to apply!

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title Associate Scientist, Analytical Development.

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies harness anti-tumor immunity by combining the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine. Our robust pipeline of early-stage biologics, based on our MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses. Turnstone continues to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, and Hamilton, Canada and New York, USA.

We are currently seeking a highly qualified, motivated and experienced individual for the position of Assistant Controller, reporting to the Vice President of Finance and will interact with the Chief Financial Officer and all levels of management and third-party vendors. The ideal candidate is a licensed CPA with biotechnology or pharmaceutical experience.

This position will have accountability and responsibility for aspects of the company’s financial reporting requirements including IPO readiness and potential SEC filings (coordinate the preparation of close packages amongst key stakeholders to ensure accuracy and quality of financial statements and disclosures), risk management, variance analytics, addressing technical accounting issues arising from business transactions and manage and grow a team. This candidate will primarily be responsible for meeting each month-end close, this candidate is responsible for accounting entries requiring high accounting acumen (i.e. revenue and stock compensation expense).

The Assistant Controller will oversee integration of new accounting pronouncements. This position will also assist in building the infrastructure, processes and controls to achieve SOX compliance. This includes working with IT to utilize existing financial systems in the most effective manner to develop scalable and efficient accounting processes.

This individual frequently interacts with accounting staff, IT, HR, Legal, International Operations (travel necessary for close at first) and other key stakeholders across the organization as well as external auditors. This role requires critical thinking skills, effective organizational skills, excellent written and verbal communication skills, and a strong ability to build effective relationships across the Company.

RESPONSIBILITIES

• Manage external reporting process, working with accounting, FP&A and consultants; assist in gathering data from key stakeholders to prepare schedules and analytics
• Responsible for leading and managing aspects of month end close, technical accounting, equity accounting, Stock option & ESPP, purchase to pay and payroll cycle
• Work with external auditor to manage the audit process
• Responsible for managing staff and review of full purchase to pay cycles and payroll cycle
• Prepare and communicate the quarterly close reporting calendar, which involves coordinating key timelines and deliverables to the external auditors, legal team, tax partner and senior mgmt.
• Manage the timely and accurate preparation, review and filing of all external financial reports, including those potentially filed with the SEC on Form 10-Q, 10-K and 8-K and associated consolidated financial statements, footnotes, management discussion and analysis
• For the Company’s financial statements, prepare disclosure checklists and disclosure meeting presentations, ensure the filings are properly formatted and accurate and perform XBRL tagging
• Comply with internal controls related to the SEC reporting process in support of management’s and the external auditors’ assessment of internal controls over financial reporting
• Staying abreast of new accounting principles, SEC reporting and general trends within the financial services industry
• Develop and own tax function working with external consultant
• Assess quarterly transactions for disclosure, perform technical accounting and IRS ruling research, draft memos
• Coordinates/monitors/reviews the execution of key processes including those in support of management’s assessment of internal controls over financial reporting in accordance with the COSO Framework and Sarbanes-Oxley Act (SOX)
• Ensures integrity of the company’s accounting system, including new account, department and project set-up, financial report development and maintenance, and interfaces between payroll, equity, financial planning and expense management systems to the general ledger
• Provides support to all other teams across the company as needs arise, including special projects, system improvements or ad-hoc financial analyses as assigned

QUALIFICATIONS/SKILLS REQUIRED

• 8+ years of relevant experience (biotech/pharma industry preferred)
• Active CPA (Big four audit experience preferred)
• Strong knowledge and understanding of US GAAP and SEC Regulations.
• Proficiency in Excel and Word and ability to learn new systems quickly are required
• An independent problem-solver with strong work ethics and intellectual curiosity will thrive
• Attention to detail, ability to multi-task, and strong interpersonal skills including verbal and written communication are essential in this collaborative work environment
• Requires strong leadership and diplomacy skills to guide teams and facilitate collaboration
• Bachelor’s degree (MBA Preferred) in Accounting or Finance with progressive accounting experience in publicly traded companies
• Experience with integrated systems including financial reporting, general ledger, purchasing, payables management (NetSuite ERP a plus)
• Experience with assessing, designing and implementing internal controls over financial reporting
• Ability to engage peers from across the organization and direct/indirect reports
• Ability to work in a dynamic work environment
• Biotech/Pharma experience
• Strong team orientation and highly collaborative

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.