ABOUT US

Our Mission

Turnstone Biologics’ mission is to deliver breakthrough viral immunotherapies to improve survival for patients with cancer.

Turnstone Biologics is a privately-held immuno-oncology company based in Ottawa, Ontario. Since 2015, we have raised $50 million in venture capital financing, brought in more than $100 million in non-dilutive funding, and have received numerous biotechnology industry awards, including being named a 2017 Fierce 15 company.

 

Our scientific founders, Drs. John Bell, David Stojdl and Brian Lichty, are world leaders in the oncolytic virus and immunotherapy field. Collectively, they have published more than 200 publications in leading journals, and have spent years engineering and developing viruses to create the next generation of powerful, targeted therapies for cancer patients.

 

Our passionate team of leaders in oncology has decades of experience in biotechnology, academia and pharmaceutical drug development. With comprehensive capabilities in immuno-oncology discovery, basic research, translation, clinical development, manufacturing, and commercialization, we are committed to bringing new medicines to people with cancer to improve their lives.

 

our science

Breakthrough Viral Immunotherapies

Turnstone Biologics is the sole company developing viral immunotherapies that drive benefit through simultaneous generation of targeted immune responses and modulation of the tumor environment.

The Maraba Virus

Turnstone Biologics’ founders screened hundreds of viruses before discovering that Maraba, a single-stranded RNA virus isolated from sand flies around the Maraba region of Brazil, was an optimal platform for cancer therapeutics. Maraba was engineered to MG1 to optimize its safety, selectivity, manufacturability and potency to kill tumor cells, and transgene capacity was added for targeted expression of tumor-associated antigens and immunomodulatory agents.

MG1: The First 2-In-1 Approach

Our engineered oncolytic Maraba virus, known as MG1, is the first therapeutic 2-in-1 approach to combine an oncolytic virus and an antigen-specific cancer vaccine. With its unprecedented dual-mechanism driving robust killer T cell responses and disrupting the tumor microenvironment, MG1 kills cancer cells at metastatic sites throughout the body, and generates a durable immune response resulting in long-term memory to prevent recurrence.

our pipeline

Driven by Science and Innovation

At Turnstone Biologics, we are science-driven: science informs our research, clinical development and approach for patients. We have developed a robust pipeline of new medicines for multiple solid tumors.

Our first program is an engineered Maraba virus (MG1) that expresses the tumor-associated antigen MAGEA3, which is highly expressed on many different types of solid tumors. We are evaluating this therapy in patients with non-small cell lung cancer (NSCLC), breast cancer and esophageal cancer in two clinical trials – alone and in combination with the anti-PD-1 checkpoint inhibitor Keytruda™. We expect to begin human studies with our second MG1 therapy for patients with human papillomavirus (HPV) positive tumors in 2018, and have multiple other viral immunotherapies in development.

 

Program Pipeline

For more information about the MAGEA3 monotherapy trial click here and the MAGEA3 and anti-PD-1 combination trial click here.

our team

Leadership

Turnstone Biologics was founded by world-leading experts in oncolytic viruses and immunotherapies who have defined and advanced the field over the course of multiple decades. Our leadership team includes experts from academia and the life sciences industry who share the vision of bringing innovative viral immunotherapies based on our unique oncolytic Maraba virus platform to patients.

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Sammy Farah, Ph.D., M.B.A.

Sammy Farah, Ph.D., M.B.A.

President and Chief Executive Officer

Dr. Sammy Farah has extensive vaccine expertise and almost 20 years of scientific, business and executive management experience in the biotechnology industry. He joined Turnstone Biologics from Synthetic Genomics Vaccines, Inc., where he served as President. Prior to that, he was Chief Business Officer of Immune Design Corp. And before then, Sammy was at Versant Ventures where he specialized in biotechnology investing and new company formation, and at Merck & Co., Inc. where he led technology support for multiple commercial vaccine franchises before joining the business development and licensing group to evaluate and execute new external technology and research partnerships. Dr. Farah earned an M.B.A. from the Wharton School at the University of Pennsylvania, a Ph.D. in biochemical engineering from Stanford University, and a B.S. in biochemical engineering from the Massachusetts Institute of Technology.

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Mike Burgess, MBChB, Ph.D.

Mike Burgess, MBChB, Ph.D.

President of R&D

Dr. Mike Burgess brings 20 years of drug research and development experience to Turnstone Biologics. At Bristol-Myers Squibb, he led strategy and execution of translational medicine, early-stage clinical trials and clinical pharmacology across all therapeutic areas, including oncology. Prior to this at Roche, Mike held several different senior leadership positions, including acting global head of Roche Pharma Research and Early Development (pRED) and Senior Vice President and Global Head of Oncology Research and Early Development. Before joining Roche, Mike spent 7 years at Lilly working on early stage oncology trials. Mike received his medical degree (MBChB) and a Ph.D. in molecular biology from the University of Bristol, UK and spent 10 years as a practicing physician in pediatrics and pediatric oncology.

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Jane Pritchett Henderson

Jane Pritchett Henderson

Chief Financial Officer

Jane Pritchett Henderson brings nearly 30 years of experience in health care and life sciences to her new role as Chief Financial Officer of Turnstone. Previously, she served as Chief Financial Officer and Senior Vice President of Corporate Development of Voyager Therapeutics since January 2017. Prior to Voyager, Ms. Henderson served as Chief Financial and Business Officer of Kolltan Pharmaceuticals, Inc., having joined the privately held biopharmaceutical company in early 2013 and leading the sale of Kolltan to Celldex Pharmaceuticals, Inc., in late 2016. Prior to Kolltan, Ms. Henderson served in various financial and business development leadership roles at ISTA Pharmaceuticals, Axerion Pharmaceuticals and Panacos Pharmaceuticals. In her more than 19 years in healthcare investment banking, Ms. Henderson executed more than 95 mergers and acquisitions, advisory and financing deals, holding senior roles at HSBC Holdings plc, Canadian Imperial Bank of Commerce, Lehman Brothers and Salomon Brothers. Ms. Henderson currently serves on the Board of Directors of Sesen Bio (formerly Eleven Biotherapeutics, Inc.) and Ophthotech as well as a non-profit foundation, The EQUUS Foundation.

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Kris Elverum, M.B.A.

Kris Elverum, M.B.A.

Chief Business Officer

Kris Elverum has more than 12 years of experience in the pharmaceutical/biotech industry, with expertise in corporate strategy, business development, commercial and operations. He joined Turnstone Biologics from SQZ Biotech, a pre-clinical stage biotechnology company developing cell therapies, where he was Chief Business Officer. Prior to that, he led the U.S. commercial model for CTL019, Novartis’ breakthrough CAR-T cell therapy, and other CAR-T cell immunotherapies. Earlier in his career, he held various commercial roles for Novartis Pharmaceuticals and served as Global Head of Strategy for Sandoz. Before that, he was an Engagement Manager with McKinsey & Co. where he served clients across the healthcare value chain. Kris earned an M.B.A. and a B.S. from the University of Minnesota’s Carlson School of Management.

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Brian Lichty, Ph.D.

Brian Lichty, Ph.D.

Senior Vice President, Basic Research

Dr. Brian Lichty is a distinguished scientist with extensive expertise in oncolytic viruses and related immunotherapies, including seminal work with Dr. John Bell at the Ottawa Regional Cancer Centre. He is a professor in the Department of Pathology & Molecular Medicine and the McMaster Immunology Research Centre (MIRC) at McMaster University. Dr. Lichty’s expertise includes influence research in the identification of strategies to leverage oncolytic viruses to harness the patient’s immune system in a sustainable manner, including vaccine design and engineering to directly engage the adaptive immune system tumor-specific and/or to enhance combinations with other immunotherapies. He is also director of the Robert E. Fitzhenry vector lab at McMaster University where clinical-grade viral vaccines are manufactured for human clinical trials. Dr. Lichty earned a Ph.D. from the University of Toronto and a B.Sc. from the University of Guelph.

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José Manuel Otero, Ph.D.

José Manuel Otero, Ph.D.

Vice President, Manufacturing & CMC

Dr. José Manuel (Manny) Otero has 15 years of experience in the biopharmaceutical industry, including in bioprocess development, manufacturing, and CMC of vaccines and complex biologics. He joined Turnstone Biologics from Seres Therapeutics, Inc., a leader in human microbiome therapeutics, where he was Vice President of Bioprocess Development and Manufacturing. At Seres Therapeutics, Dr. Otero oversaw the expansion of the bioprocess development and manufacturing group, and was the corporate team leader for the first synthetic microbiome therapeutic to enter Phase 1b clinical studies in the United States. Prior to that, Dr. Otero was Director of Engineering at Merck & Co.’s Vaccine Manufacturing Sciences & Commercialization division. In that role, he supported development programs for the Varivax™, Zostavax™, ProQuad™, and MMRII™ franchises. Prior to that role, he was Head of Fermentation Process Development, Vaccine Process Development within Merck Research Labs. Dr. Otero has authored more than 20 peer-reviewed publications. He earned a Ph.D. in chemical and biological engineering from Chalmers University of Technology in Gothenburg, Sweden, and an M.Eng. in biomedical engineering and a B.S. in chemical engineering from the Massachusetts Institute of Technology.

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Maura Campbell, Ph.D.

Maura Campbell, Ph.D.

Vice President, Corporate Affairs

Dr. Maura Campbell has spent more than 20 years in technology transfer and the management and commercialization of intellectual property (IP). She has business management experience in all key sectors of biotech, including private and public companies, universities and research institutes, and government-funded public sector research organizations (National Centre of Excellence [NCE]). Maura joined Turnstone Biologics from VBI Vaccines where she served as Director, Intellectual Property. She also was with the Ottawa Hospital Research Institute (OHRI) as a Senior Research Program Manager, where she oversaw the oncolytic vaccine project commercialization. Earlier in her career, Maura was the Director of Intellectual Property for PainCeptor Pharma Corporation, the Manager of Technology Transfer & Commercialization for the OHRI, and the Manager of Technology Transfer at the Institute for Robotics and Intelligent Systems at NCE. She has served as an IP consultant to a number of Canadian start-ups including Neurochem, Conjuchem, Aonix, AMRIC and Sussex Research Labs. Maura received a Ph.D. in biochemistry from the University of Ottawa, and an M.Sc. and a B.Sc. in biochemistry from Queen’s University in Kingston.

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Caroline Breitbach, Ph.D.

Caroline Breitbach, Ph.D.

Vice President, Translational Development

Dr. Caroline Breitbach joined Turnstone Biologics from SillaJen Biotherapeutics (formerly Jennerex) where she was Vice President, Clinical and Translational Research. In that position, she oversaw translational and early-stage clinical development of an oncolytic immunotherapy and contributed to lead candidate development from Phase 1 through initiation of Phase 3 evaluation. Previously, she worked in Dr. John Bell’s group at the University of Ottawa, where she evaluated acute effects of oncolytic viruses on the tumor immune microenvironment. She earned a Ph.D. in biochemistry from the University of Ottawa and an Honor’s B.Sc. in microbiology and immunology from McGill University.

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John Bell, Ph.D.

John Bell, Ph.D.

Ottawa Hospital Research Institute

Dr. John Bell began his independent research career at McGill University before moving to the University of Ottawa and becoming a professor in the Department of Medicine. He is a member of the Center for Innovative Cancer Therapeutics at The Ottawa Hospital Cancer Center and a Senior Scientist at the Ottawa Hospital Research Institute. He heads the Canadian Oncolytic Virus Consortium, a Terry Fox-funded group from across Canada that is developing virus-based cancer therapeutics, and is the Director of the Biotherapeutics Program at the Ontario Institute for Cancer Research. John is the Scientific Director of the National Centre of Excellence for the development of Biotherapeutics for Cancer Therapy and a Fellow of the Royal Society of Canada. Dr. Bell received a Ph.D. from McMaster University and then trained at the Medical Research Council in London, U.K.

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Brian Lichty, Ph.D.

Brian Lichty, Ph.D.

McMaster University

Dr. Brian Lichty is a distinguished scientist with extensive expertise in oncolytic viruses and related immunotherapies, including seminal work with Dr. John Bell at the Ottawa Regional Cancer Centre. He is a professor in the Department of Pathology & Molecular Medicine and the McMaster Immunology Research Centre (MIRC) at McMaster University. Dr. Lichty’s expertise includes influence research in the identification of strategies to leverage oncolytic viruses to harness the patient’s immune system in a sustainable manner, including vaccine design and engineering to directly engage the adaptive immune system tumor-specific and/or to enhance combinations with other immunotherapies. He is also director of the Robert E. Fitzhenry vector lab at McMaster University where clinical-grade viral vaccines are manufactured for human clinical trials. Dr. Lichty earned a Ph.D. from the University of Toronto and a B.Sc. from the University of Guelph.

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David Stojdl, Ph.D.

David Stojdl, Ph.D.

University of Ottawa

Dr. David Stojdl pioneered the exploration of host-virus interactions critical to oncolytic therapy to guide the clinical development of more effective virus platforms. At the Ottawa Regional Cancer Centre, he first identified VSV as an oncolytic virus and defined the archetypal role of interferon signaling in tumor-specific oncolytic virus targeting. Since joining the CHEO Research Institute in 2004, Dr. Stojdl has discovered and developed several novel oncolytic vector platforms, including the Maraba oncolytic virus platform. Dr. Stojdl also directs the CHEO Automated Screening Centre (CASC), leveraging state-of-the-art high-throughput robotic screening technology to uncover new insights for the clinical development of oncolytic virus biotherapies. Dr. Stojdl is a professor in the Department of Pediatrics and Department of Biochemistry, Microbiology and Immunology at the University of Ottawa. He was a scientific co-founder and consultant to Jennerex Biotherapeutics (later acquired by SillaJen Biotherapeutics). He received a Ph.D. from the University of Ottawa and an M.S. and B.S. in microbiology and immunology from the University of Western Ontario.

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Brad Bolzon, Ph.D.

Brad Bolzon, Ph.D.


Dr. Brad Bolzon is a Managing Director at Versant Ventures and on the biotech investment team. He has more than 13 years of global pharmaceutical industry experience. He specializes in early-stage biotech investing with a particular emphasis on new company start-ups. Prior to joining Versant, Brad served as Executive Vice President, Global Head of Business Development, Licensing & Alliances for F. Hoffmann-La Roche. Under his leadership, Roche established alliances with more than 75 biotech companies worldwide and significantly strengthened its product pipeline. Previously, Brad held executive roles at Eli Lilly in drug discovery, clinical research, regulatory affairs, and business development.

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Jerel Davis, Ph.D.

Jerel Davis, Ph.D.


Dr. Jerel Davis is a Managing Director at Versant Ventures and is based in Vancouver. Since joining Versant in 2011, he has played a critical role in launching and investing in a number of Versant’s portfolio companies including Quanticel Pharmaceuticals, Crispr Therapeutics, Blueline Bioscience, Northern Biologics and several of the Inception Sciences discovery start-ups. He has also led Versant’s execution of build-to-buy structured acquisitions with Celgene, Roche and Bayer. Over the last few years, Jerel has focused on establishing Versant’s presence in Canada, including the launch of new companies in Vancouver, Toronto and Montreal. Prior to joining Versant, Jerel was Associate Principal at McKinsey and Company where he advised pharmaceutical, biotechnology, medical device and molecular diagnostics companies. He has worked in a number of healthcare markets globally including the United States, Europe, China, Russia and India. Jerel was a post-doctoral researcher at Stanford University and worked in research at Amgen.

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Rishi Gupta, J.D.

Rishi Gupta, J.D.


Rishi Gupta is a private equity partner at OrbiMed. Prior to that, he was a healthcare investment banker at Raymond James & Associates, served as manager of corporate development at Veritas Medicine and was a summer associate at Wachtell, Lipton, Rosen & Katz. Rishi has published scientific articles on the mechanisms of HIV entry into host cells and legal articles on intellectual property laws in the developing world. In addition to Turnstone Biologics, he serves or has served on the boards of Dimension Therapeutics, Symbiomix Therapeutics, Avitide, Verona Pharma, ChemoCentryx and Sientra. He has also been actively involved with OrbiMed’s investments in Acceleron Pharma, CoGenesys, Supernus Pharmaceuticals, Adimab, Receptos, Aragon Pharmaceuticals, Seragon Pharmaceuticals, Alector, Arsanis, Biotie, Invitae and ORIC Pharmaceuticals. Rishi earned a J.D. from the Yale Law School and an A.B. degree magna cum laude in biochemical sciences from Harvard College.

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Ben Auspitz

Ben Auspitz


Ben Auspitz is a Partner at F-Prime Capital and has worked in the pharmaceutical and life science industry for more than 20 years, both as a consultant and investor. Before joining F-Prime Capital, he served as Therapeutic Area Head for immuno-inflammatory products at CombinatoRx Inc. during its growth from an angel-backed start-up to a publicly-listed company. In that role, he oversaw the advancement of seven programs from assay stage into Phase 2 clinical studies, and was co-inventor on 15 product patents. Ben focuses on therapeutics and has a particular interest in Series A and company formation — including first venture investments in Ultragenyx, REGENX Biosciences, Symbiomix Therapeutics, Precision Biosciences, Unum Therapeutics, and two companies for which he was a company founder, Orchard Therapeutics and Dimension Therapeutics. He currently serves on the board of directors of Unum Therapeutics, Precision Biosciences, Orchard Therapeutics, Symbiomix Pharmaceuticals and Compass Therapeutics. Previously, Ben was involved in F-Prime Capital investments in Bikam Pharmaceuticals (acquired by Shire), Ligocyte Pharmaceuticals (acquired by Takeda), Respivert (acquired by Johnson and Johnson), Blueprint Medicine (NASDAQ: BPMC), Coherus Biosciences (NASDAQ: CHRS), REGENXBio (NASDAQ: RGNX), Dimension Therapeutics (NASDAQ:DMTX), and Ultragenyx (NASDAQ: RARE). He received a B.A. from Harvard University.

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David O’Neill, Ph.D.

David O’Neill, Ph.D.


David O’Neill brings extensive experience in Pharma and biotech to his role as Acting President of FACIT.  FACIT is the commercialization partner of the Ontario Institute for Cancer Research and an active seed stage investor.  Dr. O’Neill has a wealth of networks and transaction experience through various business development roles at AstraZeneca, Ambit Biosciences (Daiichi Sankyo), Kinomescan (Discoverx/Eurofins), Fluorinov Pharma (Trillium Therapeutics).  He also held operational roles including non-clinical safety, IND submission and Project Leader during clinical development of Quizartinib.  He has provided interim executive management to FACIT spin outs Turnstone, Propellon and Novera Therapeutics. In addition to serving on the Board of Turnstone, he is also a Board Observer for Fusion Pharmaceuticals.  Dr. O’Neill holds a Ph.D from Western University from the Faculty of Health Sciences with an emphasis on heat shock protein biology.

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Sammy Farah, Ph.D. M.B.A.

Sammy Farah, Ph.D. M.B.A.


Dr. Sammy Farah has extensive vaccine expertise and almost 20 years of scientific, business and executive management experience in the biotechnology industry. He joined Turnstone Biologics from Synthetic Genomics Vaccines, Inc., where he served as President. Prior to that, he was Chief Business Officer of Immune Design Corp. And before then, Sammy was at Versant Ventures where he specialized in biotechnology investing and new company formation, and at Merck & Co., Inc. where he led technology support for multiple commercial vaccine franchises before joining the business development and licensing group to evaluate and execute new external technology and research partnerships. Dr. Farah earned an M.B.A. from the Wharton School at the University of Pennsylvania, a Ph.D. in biochemical engineering from Stanford University, and a B.S. in biochemical engineering from the Massachusetts Institute of Technology.

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John Bell, Ph.D.

John Bell, Ph.D.


Dr. John Bell began his independent research career at McGill University before moving to the University of Ottawa and becoming a professor in the Department of Medicine. He is a member of the Center for Innovative Cancer Therapeutics at The Ottawa Hospital Cancer Center and a Senior Scientist at the Ottawa Hospital Research Institute. He heads the Canadian Oncolytic Virus Consortium, a Terry Fox-funded group from across Canada that is developing virus-based cancer therapeutics, and is the Director of the Biotherapeutics Program at the Ontario Institute for Cancer Research. John is the Scientific Director of the National Centre of Excellence for the development of Biotherapeutics for Cancer Therapy and a Fellow of the Royal Society of Canada. Dr. Bell received a Ph.D. from McMaster University and then trained at the Medical Research Council in London, U.K.

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Jeff Courtney

Jeff Courtney

In Memoriam

Jeff Courtney helped to form Turnstone Biologics and was an outstanding leader for FACIT (Fight Against Cancer Innovation Trust). Jeff’s life’s work and warm personality inspires all of us at Turnstone Biologics to drive forward our mission to help cancer patients, and we greatly miss his presence, leadership and friendship.

We are backed by top-tier investors who are committed to the company’s growth. We have raised approximately $50 million in venture capital financing since our inception.

Turnstone Biologics views strategic partnerships as a core component of our strategy and is interested in collaborating with biopharma companies, academic centers, and universities to transform patient care.

In the fall of 2017, Turnstone Biologics entered into a strategic research, option and license agreement with AbbVie for our Ad-MG1-MAGEA3 therapy and two research-stage candidates that are presently in development.

Careers

Turnstone Biologics’ team works with a sense of urgency to fulfill our mission. Our decision-making is driven by science and our therapeutics are designed with the patient in mind.

We value transparency, innovation, integrity and purpose as we collaborate to transform cancer care. If you’re a passionate person, and our mission and science excite you, Turnstone Biologics might be for you.

Team Member Openings

Turnstone Biologics is dedicated to excellence and innovation in every aspect of our science and business. We are actively looking for exceptional individuals who share our passion for developing and delivering next-generation viral immunotherapies. We offer competitive compensation and benefits and are an equal opportunity employer.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:

The Sr. Manager/Associate Director, Regulatory Affairs position is located in New York City and reports to the Senior Director, Regulatory Affairs.  The successful candidate will work directly with the Head of Regulatory Affairs to develop and implement innovative global regulatory strategies for novel early-stage oncolytic virus immunotherapies. S/he will lead and coordinate the preparation of Regulatory documents across cross-functional teams (Nonclinical, CMC, Clinical) and file submissions to Health Authorities according to current regulatory requirements and applicable timelines.

Responsibilities:

  • Serve as a Regulatory Lead on cross-functional program teams for products in Turnstone’s pipeline, providing strategic regulatory advice as required on all aspects of Regulatory during all stages of development
  • Responsible for planning and coordinating regulatory submissions necessary to support global clinical trials, with a view towards global product registration
  • Ensure global regulatory compliance with current applicable regulatory legislation and guidelines
  • Serve as a liaison to global Health Authorities, as applicable
  • Compile, edit, review, and submit INDs, CTAs, MAAs, and BLAs in eCTD-compliant regulatory submission format
  • Provide strategy for and compile additional applications such as Orphan, Fast Track, Breakthrough Therapy, annual reports/DSUR
  • Proactively communicate with internal stakeholders to lead and ensure regulatory strategy is understood, aligned with Program milestones and implemented by cross functional teams
  • Keep apprised of regulatory intelligence developments and communicate actionable feedback to functional teams
  • Proactively manage vendors e.g., local regulatory consultants and eCTD publisher

Experience & Qualifications:

  • BSc Required, MS/PhD preferred
  • Masters Regulatory Affairs/RAC is an asset
  • Previous experience with oncology and complex biologics preferred
  • Experience with CDRH and companion diagnostics preferred
  • Experience leading, preparing and conducting regulatory agency meetings
  • Knowledge of FDA, EMA, Health Canada, and other relevant regulatory bodies and related agencies
  • Ability to think strategically and creatively to proactively identify regulatory issues across all stages of the development process
  • Ability to work independently or as part of a team, especially with employees in other locations
  • Comfortable managing multiple projects and ability to adapt to changing priorities
  • Highly effective written and verbal communication skills and computer skills

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title SENIOR MANAGER – REGULATORY AFFAIRS.

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

 

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:

The Animal Research Technician is located in Hamilton and will bring hands-on experience with mouse husbandry and procedures such as syngenic murine tumour models, intravenous and intramuscular injections, blood collection and necropsy, including experience with processing blood and tissues for ex vivo analysis. The incumbent will conduct laboratory activities including performing experiments, analyzing data, and will work closely with other lab members.

Responsibilities:

  • Application of preclinical models to enable the translation of cancer therapies
  • Characterizing in vivo models, ex vivo assays, syngeneic tumour models, mouse models to optimize their application in preclinical and translational studies for targeted therapies, cancer immunotherapies and combination therapies
  • Be highly involved in mouse animal handling requiring subcutaneous, intraperitoneal and intravenous injections, frequent tumor measurements, and regular health monitoring of animals
  • Performs blood collection through multiple routes, gaseous anaesthesia, tissue harvesting, and animal necropsies
  • Be involved in work with culture and/or cell separation methods; virus preparation; drug preparation
  • Provide technical support for assays: viral titration, flow cytometry, and fluorescence microscopy
  • Operate lab equipment such as centrifuges, pH meters, analytical balances, spectrophotometers, light microscopes and other equipment as instructed
  • Performs simple or moderately complex technical procedures
  • Participates in data entry and data analysis, including application of statistical analysis techniques using standard software
  • May perform study-related administrative tasks. Compiles data from related and/or unrelated sources
  • Communicates findings to other lab members and maintains records of experimental data
  • Must have strong interpersonal skills
  • Must have excellent verbal and written communication skills
  • Respond to and complete tasks as instructed by the P.I. and staff associated with designated research projects by carrying out the requested activities
  • Must have a willingness to perform repetitive tasks
  • Action oriented and eager to take on new opportunities and tough challenges with a sense of urgency, high energy, and enthusiasm
  • Ability to work and contribute in a fast-paced, collaborative team environment

Experience & Qualifications:

  • BSc in related science; or Medical Laboratory Technology certification; or an equivalent combination of education and experience.
  • 2-5 years’ experience working in research in either an academic or biotech/pharma setting with strong mouse-handling skills
  • Working knowledge of CCAC guidelines, OMAFRA regulations and animal use protocols (AUPs)
  • Knowledge and familiarity with regulations, standards, and guidelines for care and use of vertebrate animals in teaching, research, and service
  • All work must be performed at the highest quality and with the highest regard for animal welfare.
  • Must have attention to detail and excellent record keeping skills
  • Must possess an excellent work ethic, maintain a professional attitude and maintain high standards to detail, being able to work independently and in a team environment with the ability to interact positively with other team members
  • Must be able to detect, analyze and resolve issues professionally as they arise

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title ANIMAL RESEARCH TECHNICIAN (Hamilton).

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:

The position is located in Ottawa and reporting to the SVP, Discovery.  The position of Scientist/Immunologist is to manage all aspects of the discovery, validation and preclinical development to advance a novel neoantigen immunotherapy from the discovery phase into the clinic.  The incumbent will demonstrate their ability to participate in a highly matrixed and innovative research environment with a track record of translating basic research findings into novel therapeutic strategies that support clinical drug development.  They will contribute to the technical development and testing of a first-in-class personalized immunotherapy, meshing tumour genomics with individualized vaccine construction.  The position contributes both intellectually and experimentally as part of a multidisciplinary team with the development of strong cross-functional relationships being important for success.

Responsibilities:

  • Conduct research and design experiments that focus work in tumor and immune cell target identification/validation leading to innovative next generation biologics and modalities.
  • Utilize expertise to independently design, execute and analyze experiments using cellular and molecular immunological assays to investigate and uncover novel target biology and technologies to foster neoantigen targeted immunotherapy.
  • Effectively collaborate with other members of the company, including external collaborators and partners.
  • Prepare and present hypotheses, on-going progress reports, technical reports and future plans (including contributing to budget strategic presentations).
  • Supervise students and/or laboratory and research technicians in equipment management (e.g., flow cytometer) and ethical treatment of animals in research.
  • Contribute to building a culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.

Experience & Qualifications:

  • Must hold a Ph.D. in biology/immunology/oncology/pharmacology or a related field with 5+ years of experience or an acceptable combination of education and experience.
  • Robust understanding of innate and adaptive immune systems is required.
  • Experience with in vivo models, isolation and culture of primary cells (both mouse and human).
  • National Institutional Animal User Training Certification (NIAUT) an asset.
  • A working knowledge of immune based in vitro assays, flow cytometry and common molecular techniques.
  • Experience in T cell function/differentiation/signaling/regulation, phenotypic analysis of inhibitory and costimulatory targets and pathways and/or neoantigen biology and vaccines is highly preferred.

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title SCIENTIST-IMMUNOLOGIST. Although not required, you are invited to include your salary expectations in your cover letter.

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being the key “go-to” clinical project person, then this role may be for you! Your role will supervisor overall management and execution of operational activities involved in the planning, implementation, conduct and completion of clinical trials. You will have experience working with some or all the following, as they relate to Clinical Project Manager duties:

  • Manage and coordinate all aspects of assigned clinical trials, North America and Global, to ensure they are conducted in accordance with established protocols, Company standards (SOPs), ICH/GCP and applicable jurisdiction regulations.
  • Assists/leads the identification, evaluation and selection of external vendors (central lab, CROs, consultants/contractors, etc.).
  • Coordinates and assists in the CRO and vendor contracting process and performs ongoing vendor management to ensure deliverables and performance adhere to contract
  • Oversees, manages and reports on project activities, including scope, schedule, budget and risk associated with each assigned project.
  • Identifies and tracks key study metrics in order to identify/anticipate issues (early) and conduct root-cause investigations for issue resolution and/or escalation (as needed)
  • Develops clinical trial timelines, tracks the overall study critical path and manages/oversees all study activities to ensure on-time study delivery.
  • Reports study performance and timelines to senior management
  • Oversees the identification, selection and initiation of clinical sites
  • Oversees the development of required study plans and execution of those plans related to site monitoring, safety management, data management and biostatistics
  • Oversees development of CRFs, clinical and safety databases, and shell Tables, Figures and Listings
  • Plans, coordinates and conducts investigator meetings
  • Plans, coordinates and conducts Data Safety Monitoring Board (DSMB) meetings
  • Coordinates and manages timely database freeze and database lock.
  • Participates in data review meeting.
  • Maintains the Trial Master File for each project and oversee the archival process
  • Assists the scientific staff in developing and reviewing protocols, investigator brochures, informed consent forms, clinical study reports and other scientific documents
  • Assists Regulatory Affairs as necessary for IND/CTA filing and other necessary compliance requirements.

What’s in it for you?

In this role, you will have the opportunity to develop this role from scratch.  We have not had a field Clinical Project Manager yet at Turnstone, we have exciting current and new trials starting,  we have opportunities for you to mentor other clinical team members, we are growing fast so we have several new employees…we are all learning together.  Thus, you have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The details

This role is best suited for a some with the following:

  • BS in scientific discipline or pharmacy, RN, or BSN degree or equivalent combination of education and experience
  • Minimum 5 years of clinical trial/project management experience
  • Oncology background or experience preferred
  • Ability to travel approximately 20-50% based on study demands
  • Excellent working knowledge of GCP/ICH Guidelines
  • Ability to work effectively independently or as part of a team, remotely or in-office
  • Comfortable managing multiple projects and ability to adapt to changing priorities
  • Effective written communication skills and computer skills are required
  • Strong understanding of Clinical Development

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title Clinical Project Manager.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being a part of a growing clinical operations team, then this role may be for you! Your role will be to assist with the Turnstone Clinical and Program teams by; maintaining the study materials folder, including: site training documents, site reference binders, study presentations, CRA training material, etc. You will have experience working with some or all the following, as they relate to CTA duties:

  • With minimal supervision, provide administrative support to the Clinical, Project Management and Medical teams by maintaining the study materials folder, including: site training documents, site reference binders, study presentations, CRA training material, etc.
  • Track site visits from the clinical and medical group, including: visit coordination tasks (administrative), tracking of documentation from visits, copying and filing documents and reports, and providing metrics to the VP of Clin Ops and other management as required
  • Track vendor management activities within clinical operations including: uploading of site visit reports, scheduling of co-monitoring visits, receiving, copying, and filing documentation of this review, and providing metrics to VP Clin Ops and management staff as required
  • Tracking and recording invoices received from clinical trial vendors, and working with the VP of Clin Ops on quarterly budget review
  • Assists with the tracking of clinical trial progress within a dashboard, updates drug accountability and dispensation records, and communicates with supply chain to ensure that study supplies and IP are requested as needed
  • Track, reconcile, and process SAE reports under the guidance of the Medical Monitor
  • Assists with the development and review of clinical trial documents as assigned such as: ICF, eCRF, paper CRF, site training documents, etc.
  • Participates in clinical team meetings and interacts in a positive, professional manner.  May coordinates meetings/teleconference/BlueJeans.  May be asked to prepare agendas, minutes and tracks action items.
  • Maintains completion of required corporate training on standards, policies, work instructions by due date

What’s in it for you?

In this role, you will have the opportunity to develop your CTA skills as a jumping off point in clinical.  We have exciting current and new trials starting so this role will be busy and expanding,  we have opportunities for you to be mentor by other clinical team members, since we are growing so fast, we have several new employees…we are all learning together.  Thus, you have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The details

This role is best suited for a some with the following:

  • BA/BS or equivalent degree in a scientific discipline or related field is preferred but not required
  • 1-3 years experience in the pharmaceutical, biotechnology, CRO and/or healthcare setting is preferred
  • Demonstrate basic understanding of medical terminology and clinical activities
  • Demonstrate computer proficiency with MS Office Suite products and MAC iOS
  • Understanding in relevant clinical operations activities
  • Basic knowledge and understanding of ICH/GCP guidelines and FDA regulations required
  • Working knowledge of TMF maintenance and management of essential documents
  • Solid interpersonal, written and verbal communication skills across study team including study management
  • Desire to work within a small team environment. Must be a self-starter and able to work under limited supervision
  • Computer skills including proficiency in the use of Microsoft Word, Excel, Powerpoint, Outlook, and organization tools
  • Experience with filing systems such as Sharepoint, Dropbox, Box, or Soonr is desirable
  • Attention to detail and accuracy in work
  • Effective time management and organization skills
  • Ability to multi-task under limited direction and on own initiative

 

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title CTA.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being the key “go-to” field clinial person, then this role may be for you! Your role will assist with the monitoring, surveillance, and engagement of clinical trial sites globally. You will have experience working with some or all the following, as they relate to Sr. CRA duties:

  • Conduct Site Qualification, Site Initiation, Interim Monitoring, Site Close-out, and other study-specific visits including the completion of trip reports and follow-up letters after each visit
  • Verify that the investigator has adequate qualifications and resources including facilities, laboratories, equipment, and staff to safely and properly conduct the trial. Confirms that qualifications and resources remain adequate throughout the trial period
  • Train PI and Site Personnel on GCP/ICH, CFR regulations (if applicable) and monitor compliance
  • Ensure the collection and maintenance of required essential documents and responsible for filing within and auditing the Trial Master File and Investigator Site File
  • Ensuring the sites are adequately prepared and trained to participate in the clinical trial including protocol adherence, drug storage, receipt and preparation, drug administration procedures, data collection, etc.
  • Ensure that the investigator receives the current Investigators Brochure, all documents, and all trial supplies needed to conduct the trial properly and to comply with the applicable regulatory requirement(s)
  • Verify investigational product is handled and destroyed according to regulation
  • Report site status and develop a patient recruitment plan in conjunction with the site.
  • Verify that the investigator provides all the required reports, notifications, applications, and submissions, and that these documents are accurate, complete, timely, legible, dated, and identify the trial
  • Determine whether all adverse events (AEs) are appropriately reported within the time periods required by Good Clinical Practices (GCP), the protocol, the Ethic Committees (IRB/IEC), the sponsor, and the applicable regulatory requirement(s)
  • Communicate deviations from the protocol, SOPs, GCP, and the applicable regulatory requirements to the investigator and taking appropriate action designed to prevent recurrence of the detected deviations
  • Maintain current, accurate and complete tracking tools and provide status updates including essential documents, monitoring visits, CRF collection, data entry, query status, SAE reporting, subject screening and recruitment, supplies inventory, and overall project timelines and budgets.
  • As a senior CRA, review site budget adherence and address budget variance with VP, Clin Ops
  • As a Senior CRA, provide mentorship and oversight to junior staff members regarding clinical monitoring activities and assist with minor project management responsibilities, including: leading operational meetings/topics, updating content and presenting at Investigator Meetings, collaborating with senior clinical operations team on recruitment timelines, and reviewing monitoring reports from junior CRAs.
  • As a senior CRA, Work with senior clin ops team on developing an audit plan, reviewing and resolving audit findings/reports, and roll-out quality improvements throughout the course of the trial as needed based on auditor recommendations

What’s in it for you?

In this role, you will have the opportunity to develop this role from scratch.  We have not had a field Sr CRA yet at Turnstone, we have exciting current and new trials starting,  we have opportunities for you to mentor other clinical team members, we are growing fast so we have several new employees…we are all learning together.  Thus, you have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The details

This role is best suited for a some with the following:

  • Must possess a Bachelor’s Degree or higher. A degree in health or biological science (e.g. BS, BA, BscN, higher) is preferred
  • Industry experience working in a small to mid-sized biotechnology or pharmaceutical company is strongly preferred
  • Thorough understanding of the clinical trial development process and knowledgeable (with documented training) on ICH/GCP guidelines and US FDA CFR
  • Experience with IND/protocol submissions, and Appendix M/NIH submissions preferred
  • Understanding and knowledge of hospital operations particularly as they pertain to patient management, standard universal precautions, logistics, patient recruitment, etc.
  • At least 2 years of Independent monitoring experience required. Candidates with oncology experience, will be given the highest priority, but extensive monitoring experience particularly in infectious disease or autoimmune indications may be considered in lieu of oncology experience.
  • International monitoring experience (e.g. Canada) or managerial experience outside the US strongly preferred
  • Strong attention to detail
  • Solid interpersonal, written and verbal communication skills
  • High-energy, self-starter
  • Flexible and dynamic, willing to “wear a lot of hats”
  • Desire to work within an international team environment. Growth potential within a global company headquartered in New York and Ottawa.
  • Proficient in MS Word, Excel, PowePoint is required. Knowledge of MS Project preferred
  • Effective time management and organization skills
  • Self-starter with a “can-do” attitude who can work independently and multi-task under limited direction and on own initiative, but still must also be able to function flexibility within a small team environment
  • Must be field based and travel +50% is required, including international travel. Candidate must therefore possess a valid passport or be able to obtain one within 4 weeks of hiring.
  • Infectious disease, oncolytic virus experience, and/or cancer vaccine experience highly preferred.

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title Sr CRA.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing clinical team that embraces being a learning organization with a sense of urgency, where clinical is a differentiator and enabler rather than a cost-center. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

The company has multiple programs either in the clinic or in late stage preclinical development. Establishing high quality scientific and development capabilities is essential for the success of the company. This position reports to the President of R&D:

Key responsibilities include:

Clinical Development:

  • Responsible for clinical development strategies including phase 1 through 3, life cycle managements, medical affairs and safety reporting.
  • Oversees and participates in all interactions with regulatory agencies related to his/her clinical programs.
  • Leads and oversees the tactical development of clinical trial programs, including protocol writing, interpretation of clinical data, and literature reviews.
  • Ensures the highest quality of ethical standards and scientific methods are applied to clinical and scientific programs.
  • Ensures that clinical timelines and budgets are met and provides solutions for potential challenges to mitigate any impact on such timelines or budgets.
  • Ensures the identification, recruitment and selection of appropriate clinical investigators.
  • Partner with the supporting functions, project leadership and management, clinical operations, regulatory and biomarkers to ensure optimally integrated development
  • Partner with the Scientific Founders to provide clinical insights to better identify appropriate clinical candidates
  • Define the patient selection strategy, if required, for the assets and partners with the bioassay lead to identify the appropriate research or companion diagnostic tests.
  • Partner with internal and external thought leaders to identify trends in oncology and define efficient approaches to ensure preclinical discoveries are able to address unmet medical through cutting edge clinical development
  • As part of the R&D leadership group provide scientific, clinical and operational input to the overall R&D strategy and organization

Corporate Leadership;

  • Assist in creating a strong and dynamic scientific and medical culture consistent with the position of Turnstone Biologics as the world’s leading viral immunotherapy company
  • Present to the Board and/or Scientific Advisory Board and/or to external investor groups as required.
  • Enhance the external presence of the company through presentations at scientific meetings, to academic cooperative groups and to the investigator community.
  • Support business development and provide clinical and scientific expertise to external partnerships.

Key requirements include:

  • A MD/PhD with a strong background in immuno-oncology and a track record of leading academic and clinical research
  • Excellent scientific rigor and experience in overseeing multiple programs in oncology and hematology
  • Proven pharmaceutical experience working with both preclinical research and clinical development
  • An ability to work in a small scientifically driven biotech company in which resources may be limited and hence a willingness to work beyond job title and scope to ensure the success of the programs and company.
  • Strong external presence with key opinion leaders within the immuno-oncology world
  • A track record of success in delivering on goals with academic and industrial partners. Demonstrated success at recruiting and retaining highly qualified talent

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title VP – CLINICAL DEVELOPMENT.

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing CMC team that embraces being a learning organization with a sense of urgency, where CMC is a differentiator and enabler rather than a cost-center. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

What’s in it for you?

In this role, you will have the opportunity to design, build, implement, and operate a clinical manufacturing supply chain for our suite of novel biotherapeutics to combat cancer. On the heels of a successful Series B financing, Turnstone’s CMC team is expanding to support the development of several parallel candidates towards the clinic. Joining Turnstone at this early phase, will allow you to actively participate in developing a role designed just for you. One that leverages your expertise, while challenging you to develop new skills. This role will include driving a raw materials inventory, product inventory, distribution, and warehousing, all while serving as the primary contact amongst our network of external products to move product from R&D to GMP manufacturing to the patients we serve. Fortunately, the Turnstone CMC team has already initiated two clinical studies with Health Canada, so you’re not starting from zero, but we need someone to really own, drive, and lead our supply chain, showing us how the professionals do it, all while remaining flexible, dynamic, working with a sense of urgency, and innovation. This is definitely a ‘roll up your sleeves’ role, but we’re hiring a leader that is setting the foundation for mature, manufacturing supply chain capable of supporting late-stage (Ph3/Pivotal) clinical studies, and commercial launch – you will bring the vision.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Wednesday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in leading critical procurement, warehousing, and logistics operations under highly fluid, rapidly changing conditions – this job is for you! You’ll enjoy a diverse role as you partner closely with various groups such as Manufacturing Sciences & Technology, Analytical Development and Quality Control, Manufacturing Operations, Quality Assurance, and Clinical Operations to ensure all types of materials are procured, appropriately distributed, and stored in a compliant manner. In addition, you’ll partner closely with CDMOs, CROs, and CTOs to manage relationships, negotiate pricing and terms, and conquer challenges.  You’ll use your well-developed communication skills in monitoring and enforcing requirements with all vendors and as you work with internal stakeholders at all levels.  You’ll have experience working with some or all of the following, as they relate to supply chain management:

  • Inventory and Enterprise Resource Management systems
  • Procurement systems
  • Critical logistics, including import/export, cold chain, and time-sensitive shipping
  • External vendors, including critical material suppliers and contract development/manufacturing organizations (CDMOs), contract testing organizations (CTOs), and contract research organizations (CROs)
  • Warehouse materials management, including receipt, storage, issuance, and shipping, preferably at multiple sites
  • Quality systems (change control, deviations, corrective and preventive actions, document control)
  • Experience with Lean principles, Kanban, Just-In-Time logistics, Continuous Improvement, etc. are a plus. This is definitely a ‘hands-on’ role with incredible upside opportunities.

The details

This role is best suited for supply chain professionals with significant experience developing and managing a GMP clinical manufacturing supply chain. You’ve likely studied supply chain and logistics, or perhaps were a classically trained scientist/engineer and supplemented your education to be successful. You must be able to demonstate both leadership and a willingness to be a ‘do-er’, likely having 5 years or more experience in GMP manufacturing supply chain and logistics. You have demonstrated the ability to manage both small and large projects, multi-tasking effectively, and having an external presence that is professional, collaborative, and influential. You will need to travel monthly to our various vendors, and also visit our Ottawa and NYC offices often to stay connected, productive, and excited. This role will report to the Vice President of CMC/Manufacturing at Turnstone and be a part of the CMC Leadership Team. Based on a mutual discussion of fit, the successful candidate(s) will reside at either the Ottawa or New York office location.

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title MANUFACTURING SUPPLY CHAIN LEADER.


Turnstone Biologics welcomes and encourages applications from people with disabilities.
Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing CMC team that embraces being a learning organization with a sense of urgency, where CMC is a differentiator and enabler rather than a cost-center. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

What’s in it for you?

In this role, you will have the opportunity to lead, drive, and own GMP clinical manufacturing operations for a suite of novel biotherapeutics to combat cancer. On the heels of a successful Series B financing, Turnstone’s CMC team is expanding to support the development of several parallel candidates towards the clinic. Joining Turnstone at this early phase, will allow you to actively participate in developing a role designed just for you: one that leverages your expertise, while challenging you to develop new skills. This role will include partnering very closely with our Manufacturing Sciences & Technology group to understand the Drug Substance and Drug Product processes, with a collaborative effort to successfully transfer those processes to our network of CDMOs. Once transferred, you will lead all manufacturing operations including batch production record management, manufacturing schedule, providing ‘on-the-floor’ review and support as required, and overcoming challenges related to manufacturing deviations. You are truly the relationship manager and interface between Turnstone Biologics and our Manufacturing partners, representing us with the professionalism, creativity, and collaborative spirit that embodies who we are. Fortunately, the Turnstone CMC team has already initiated two clinical studies with Health Canada, so you’re not starting from zero, but we need someone to really own, drive, and lead our manufacturing operations, showing us how the professionals do it, all while remaining flexible, dynamic, working with a sense of urgency, and innovation. This is definitely a ‘roll up your sleeves’ role, but we’re hiring a leader that is setting the foundation for mature, manufacturing operations capable of supporting late-stage (Ph3/Pivotal) clinical studies, and commercial launch – you will bring the vision.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Wednesday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you. If you are interested in leading, driving, and owning manufacturing operations for an early clinical-stage company, where you need to both provide vision and strategy while rolling up your sleeves, then this role may be for you! You’ll enjoy a diverse role as you partner closely with various groups such as Manufacturing Sciences & Technology, Analytical Development and Quality Control, Supply Chain, Quality Assurance, and Clinical Operations. You will have led GMP manufacturing operations for complex biopharmaceuticals, ideally live-virus vaccines or similar, and will have both clinical and commercial manufacturing experience. You’ll use your well-developed communication skills and ability to influence and partner very closely with our networks of CDMOs and internal stakeholders at all levels.  You’ll have experience working with some or all the following, as they relate to manufacturing operations:

  • Live-virus manufacturing experience, ideally hands-on as well as leading broader manufacturing teams or projects partners with external vendors
  • Very well versed in GMPs with a clear understading of ‘phase-appropriateness’ as well as an appreciation for continuous improvement
  • A relationship manager and primary interface for external vendors, including critical material suppliers and contract development/manufacturing organizations (CDMOs), contract testing organizations (CTOs), and contract research organizations (CROs)
  • Quality systems (change control, deviations, corrective and preventive actions, document control)
  • Experience with Lean principles, Kanban, Continuous Improvement, etc. are a plus. This is definitely a ‘hands-on’ role with incredible upside opportunities.

The details

This role is best suited for manufacturing professionals with significant experience developing and managing a GMP manufacturing operation. You’re likely a classically trained scientist/engineer and supplemented your education to be successful, particularly with training in operational excellence and manufacturing. You must be able to demonstate both leadership and a willingness to be a ‘do-er’, likely having 5 years or more experience in GMP clinical or commercial manufacturing. You have demonstrated the ability to manage both small and large projects, multi-tasking effectively, and having an external presence that is professional, collaborative, and influential. You will need to travel monthly to our various vendors, and also visit our Ottawa and NYC offices often to stay connected, productive, and excited. This role will report to the Vice President of CMC/Manufacturing at Turnstone and be a part of the CMC Leadership Team. Based on a mutual discussion of fit, the successful candidate(s) will reside at either the Ottawa or New York office location.

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title MANUFACTURING OPERATIONS LEADER.


Turnstone Biologics welcomes and encourages applications from people with disabilities.
Accommodations are available on request for candidates taking part in all aspects of the selection process. We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being a part of a growing IT and business operations team, then this role may be for you! Your role will be to work directly with the CFO and manage the global Information Technology and Informatics function.  Lead the design, implementation and growth of our information architecture.  This individual will manage infrastructure and resources to meet organizational needs and will be responsible for working cross-functionally with all departments to identify long-term, scalable, practical solutions for research and operations as the organization grows.   He/she will be expected to establish close partnerships with colleagues from multiple disciplines to translate business needs into state-of-the-art informatics solutions.  You will have experience working with some or all the following, as they relate to the Director of IT duties:

Leadership

  • Provide strong leadership and business acumen, as well as data and analytical skills and relationship-building capabilities to inspire the organization around common goals, vision and values for IT and informatics
  • Define and implement data architecture and company-wide strategy for data storage, processing, analysis and mining
  • Serve as champion for global data management, governance, quality and vendor relationships across the company
  • Establish an architecture and a collection of integrated decision-support applications and databases, providing the company easy access to corporate data.
  • Grow the breadth and depth of department expertise to meet short and long-term corporate objectives

Information Technology

  • Oversee contingency planning and IT security and compliance by establishing controls and processes in support of data security, PHI, SOX and other relevant regulatory requirements
  • Manage vendors, consultants and overall budget for data management and IT
  • Lead the planning and estimation of IT & Informatics projects
  • Regularly and effectively communicate with key project stakeholders, keeping them advised of project progress and generally making IT activities transparent to stakeholders
  • Set strategy for IT infrastructure and software capabilities for current and future organizational needs
  • Maintain ongoing knowledge of industry trends and ability to utilize that knowledge to determine the most efficient ways to meet business needs
  • Communicate strategy to scientific personnel, operations and senior management to ensure alignment
  • Measures availability, performance, capacity, and utilization of IT and Informatics services
  • Detects, monitors, reports, manages, escalates and ultimately prevents service failures and/or degradations.
  • Takes ownership of security across the board and lead IT related compliance for the Company.
  • Collaborate with others to facilitate business needs definition, workflow design and integration of scientific processes and technology into effective IT solutions
  • Understanding and familiarity with Mac, Apple iOS preferred

Research Informatics

  • Work with R&D team to develop and implement computational biology strategy, goals and evolution of the team
  • Implement and maintain key research systems, including ELN, LIMS and Results Management
  • Grow and effectively maintain cloud-based computing environment
  • Develop and implement data integration and analytics strategy

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution.  With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader.  Passionate about IT and Information and continuous learning?  We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The details

This role is best suited for a some with the following:

  • Advanced degree in life sciences, plus 7-10 years of relevant experience working in Biotech
  • 5-7 years of experience managing and implementing informatics and IT solutions in a start-up, biotech environment
  • Ability to identify impediments to complex business and research issues and provide timely and cost-effective solutions
  • Solid scientific/ technical knowledge to be able to successfully ensure project scope and fit technology for applications, networking and information systems strategic roadmap and execution of all Informatics solutions and IT services
  • Experience with evaluating, implementing and managing scientific data management platforms, cloud computing (AWS), Document control/electronic lab notebook software, on-site storage solutions and IT vendor services
  • Prior experience and record of accomplishment leading cross functional teams and delivering on schedule in a start-up biotech environment
  • Prior experience in successfully implementing, utilizing and leveraging outsourcing strategies
  • Practical understanding of relational database design and development
  • Demonstrated understanding of the software development lifecycle
  • Ability to adapt to increasing scope and complexity of work brought on by growth/change and helps others manage through change
  • Strong written, oral and public speaking communication skills.

 To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title Director, IT.

 Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being a part of a growing finance and business operations team, then this role may be for you! Your role will be to work directly with the CFO and manage the global accounting and finance function.  Oversee finance, general and technical accounting, SEC reporting in future, budget and forecasting management, tax and tax planning, equity administration, and compliance (including trading and disclosure).  You will have experience working with some or all the following, as they relate to the VP of Finance duties:

  • Lead all aspects of financial planning, budgeting and forecasting. Work closely with the executive team to plan for key revenue and cost drivers.
  • Manage cashflow and oversee accounting operations such as account receivables, payables, payroll.
  • Develop accounting systems, reporting and policies to ensure accordance with generally accepted accounting principles. Oversee timely and efficient monthly and quarterly closing process.
  • Develop the financial reporting infrastructure (e.g. program and function P&Ls) to enable strategic decisions, ongoing analysis and performance tracking for the executive team/company.
  • Partner with legal and business development on contractual terms to assess financial and accounting impact and oversee financial compliance with all significant contractual obligations
  • Help lead fundraising and financing efforts, working closely with the executive team. Help nanage ongoing relationships with financial institutions.
  • Build and lead a world-class finance and accounting team for public company.
  • Prepare and present financials to the company, board members and key stakeholders.
  • Manage global tax planning and compliance with all required federal, state, local, payroll, property and other applicable taxes.
  • Oversee cash management and act as company treasurer
  • Help manage business insurance requirements

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution.  With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader.  Passionate about finance and continuious learning?  We will have plenty of that for you! 


We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportinites for you to be mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The details

This role is best suited for a some with the following:

  • 10-15 plus years overseeing all aspects of finance and accounting, including 5+ years of public accounting including financial reporting in a SOX-compliant public company.
  • Solid track record as a manager
  • Success in building an effective financial function in a high growth biotech or life sciences environment, including implementing “best practice” policies and processes related to operations and reporting of a public company
  • Very strong analytical and technical accounting capabilities
  • Significant experience setting strategy for and managing treasury/cash management functions in a biotech or pharmaceutical organization.
  • Exceptional project management skills with the ability to multi-task, prioritize and meet deadlines in a fast-paced environment.
  • An enormous appetite for detail and precision, and ability to roll up your sleeves to do the dirty work.
  • A self-starting attitude. You work independently and effectively, with little oversight or management.
  • Experience with financings, collaborations and M&A is a plus
  • Bachelor’s degree in Accounting, Finance or Business. CPA strongly preferred but not required.
  • Experience working in a fast-growing start-up environment strongly preferred.

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title VP, FInance.

 Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Notice to Recruiters: Turnstone Biologics values our recruiting partnerships, but to protect the interest of all parties, we do not accept unsolicited resumes from recruiters. All recruiting is managed through our human resources department.

Contact

Ottawa

787 Bank Street, 2nd Floor
Ottawa, Ontario K1S 3V5
(613) 421-8930

New York City

110 East 25th Street
New York, New York 10010
(613) 421-8930

General

Please contact us with any questions
or comments.

Info@turnstonebio.com

Media

Please contact Pure Communications
for any media inquiries.

Turnstone@W2OGroup.com