ABOUT US

Our Mission

Turnstone Biologics’ mission is to deliver breakthrough viral immunotherapies to improve survival for patients with cancer.

Turnstone Biologics is a privately-held immuno-oncology company based in Ottawa, Ontario. Since 2015, we have raised $50 million in venture capital financing, brought in more than $100 million in non-dilutive funding, and have received numerous biotechnology industry awards, including being named a 2017 Fierce 15 company.

 

Our scientific founders, Drs. John Bell, David Stojdl and Brian Lichty, are world leaders in the oncolytic virus and immunotherapy field. Collectively, they have published more than 200 publications in leading journals, and have spent years engineering and developing viruses to create the next generation of powerful, targeted therapies for cancer patients.

 

Our passionate team of leaders in oncology has decades of experience in biotechnology, academia and pharmaceutical drug development. With comprehensive capabilities in immuno-oncology discovery, basic research, translation, clinical development, manufacturing, and commercialization, we are committed to bringing new medicines to people with cancer to improve their lives.

 

our science

Breakthrough Viral Immunotherapies

Turnstone Biologics is the sole company developing viral immunotherapies that drive benefit through simultaneous generation of targeted immune responses and modulation of the tumor environment.

The Maraba Virus

Turnstone Biologics’ founders screened hundreds of viruses before discovering that Maraba, a single-stranded RNA virus isolated from sand flies around the Maraba region of Brazil, was an optimal platform for cancer therapeutics. Maraba was engineered to MG1 to optimize its safety, selectivity, manufacturability and potency to kill tumor cells, and transgene capacity was added for targeted expression of tumor-associated antigens and immunomodulatory agents.

MG1: The First 2-In-1 Approach

Our engineered oncolytic Maraba virus, known as MG1, is the first therapeutic 2-in-1 approach to combine an oncolytic virus and an antigen-specific cancer vaccine. With its unprecedented dual-mechanism driving robust killer T cell responses and disrupting the tumor microenvironment, MG1 kills cancer cells at metastatic sites throughout the body, and generates a durable immune response resulting in long-term memory to prevent recurrence.

our pipeline

Driven by Science and Innovation

Our first program is an engineered Maraba virus (MG1) that expresses the tumor-associated antigen MAGEA3, which is highly expressed on many different types of solid tumors. We are evaluating this therapy in patients with non-small cell lung cancer (NSCLC) and skin cancers in two clinical trials – alone and in combination with the anti-PD-1 checkpoint inhibitor Keytruda™.  Our second MG1 therapy for patients with human papillomavirus (HPV) positive tumors is also being evaluated in a Phase I/II clinical trial, and we have additional therapies on track to enter the clinic in 2019.

 

Program Pipeline

Turnstone Biologics Pipeline

For more information about the HPV trial click here, the MAGEA3 monotherapy trial click here, and the MAGEA3 and anti-PD-1 combination trial click here.

our team

Leadership

Turnstone Biologics was founded by world-leading experts in oncolytic viruses and immunotherapies who have defined and advanced the field over the course of multiple decades. Our leadership team includes experts from academia and the life sciences industry who share the vision of bringing innovative viral immunotherapies based on our unique oncolytic Maraba virus platform to patients.

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Sammy Farah, Ph.D., M.B.A.

Sammy Farah, Ph.D., M.B.A.

President and Chief Executive Officer

Dr. Sammy Farah has extensive vaccine expertise and almost 20 years of scientific, business and executive management experience in the biotechnology industry. He joined Turnstone Biologics from Synthetic Genomics Vaccines, Inc., where he served as President. Prior to that, he was Chief Business Officer of Immune Design Corp. And before then, Sammy was at Versant Ventures where he specialized in biotechnology investing and new company formation, and at Merck & Co., Inc. where he led technology support for multiple commercial vaccine franchises before joining the business development and licensing group to evaluate and execute new external technology and research partnerships. Dr. Farah earned an M.B.A. from the Wharton School at the University of Pennsylvania, a Ph.D. in biochemical engineering from Stanford University, and a B.S. in biochemical engineering from the Massachusetts Institute of Technology.

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Mike Burgess, M.B.Ch.B., Ph.D.

Mike Burgess, M.B.Ch.B., Ph.D.

President of R&D

Dr. Mike Burgess brings 20 years of drug research and development experience to Turnstone Biologics. At Bristol-Myers Squibb, he led strategy and execution of translational medicine, early-stage clinical trials and clinical pharmacology across all therapeutic areas, including oncology. Prior to this at Roche, Mike held several different senior leadership positions, including acting global head of Roche Pharma Research and Early Development (pRED) and Senior Vice President and Global Head of Oncology Research and Early Development. Before joining Roche, Mike spent 7 years at Lilly working on early stage oncology trials. Mike received his medical degree (MBChB) and a Ph.D. in molecular biology from the University of Bristol, UK and spent 10 years as a practicing physician in pediatrics and pediatric oncology.

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Jane Pritchett Henderson

Jane Pritchett Henderson

Chief Financial Officer

Jane Pritchett Henderson brings nearly 30 years of experience in health care and life sciences to her new role as Chief Financial Officer of Turnstone. Previously, she served as Chief Financial Officer and Senior Vice President of Corporate Development of Voyager Therapeutics since January 2017. Prior to Voyager, Ms. Henderson served as Chief Financial and Business Officer of Kolltan Pharmaceuticals, Inc., having joined the privately held biopharmaceutical company in early 2013 and leading the sale of Kolltan to Celldex Pharmaceuticals, Inc., in late 2016. Prior to Kolltan, Ms. Henderson served in various financial and business development leadership roles at ISTA Pharmaceuticals, Axerion Pharmaceuticals and Panacos Pharmaceuticals. In her more than 19 years in healthcare investment banking, Ms. Henderson executed more than 95 mergers and acquisitions, advisory and financing deals, holding senior roles at HSBC Holdings plc, Canadian Imperial Bank of Commerce, Lehman Brothers and Salomon Brothers. Ms. Henderson currently serves on the Board of Directors of Sesen Bio (formerly Eleven Biotherapeutics, Inc.) and Ophthotech as well as a non-profit foundation, The EQUUS Foundation.

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José Manuel Otero, Ph.D.

José Manuel Otero, Ph.D.

SVP of Technical Operations

Dr. José Manuel (Manny) Otero has 15 years of experience in the biopharmaceutical industry, including in bioprocess development, manufacturing, and CMC of vaccines and complex biologics. He joined Turnstone Biologics from Seres Therapeutics, Inc., a leader in human microbiome therapeutics, where he was Vice President of Bioprocess Development and Manufacturing. At Seres Therapeutics, Dr. Otero oversaw the expansion of the bioprocess development and manufacturing group, and was the corporate team leader for the first synthetic microbiome therapeutic to enter Phase 1b clinical studies in the United States. Prior to that, Dr. Otero was Director of Engineering at Merck & Co.’s Vaccine Manufacturing Sciences & Commercialization division. In that role, he supported development programs for the Varivax™, Zostavax™, ProQuad™, and MMRII™ franchises. Prior to that role, he was Head of Fermentation Process Development, Vaccine Process Development within Merck Research Labs. Dr. Otero has authored more than 20 peer-reviewed publications. He earned a Ph.D. in chemical and biological engineering from Chalmers University of Technology in Gothenburg, Sweden, and an M.Eng. in biomedical engineering and a B.S. in chemical engineering from the Massachusetts Institute of Technology.

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Kristin Gustafson

Kristin Gustafson

SVP of HR and Facilities

Kristin Gustafson brings with her more than 18 years of Human Resources experience specific to the biotech and pharmaceutical sector to Turnstone. Prior to joining Turnstone, Ms. Gustafson was with Kite Pharma, a Gilead company, where she led the global Human Resource and Facilities function during a time of explosive growth and the approval of Yescarta, the first CAR-T adult immunotherapy approved by the U.S. Food and Drug Administration (FDA). Prior to Kite, she spent four years at Intercept Pharmaceuticals and served as the company’s Senior Vice President of Global Human Resources and Facilities and also served in leadership roles at Cochlear and MGI Pharma.  Kristin attended the University of Wisconsin, Madison.

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Steve Bernstein, M.D.

Steve Bernstein, M.D.

SVP of Clinical Research and Development

Steven Bernstein, M.D., has more than 20 years of experience as a treating physician, translational scientist and pharmaceutical executive.  Prior to joining Turnstone, Dr. Bernstein served as Chair, Immuno-Oncology Translational Research and Development, and Head, Integrated Science, at Bristol-Myers Squibb. Prior to BMS, he was as an academic physician scientist most recently at the University of Rochester’s James P. Wilmot Cancer Institute, where he was Professor of Medicine, Co-Director of the Hematological Malignancy and Lymphoma Biology Programs and Co-PI of the University of Rochester/Arizona Cancer Center NCI SPORE grant in lymphoma. Dr. Bernstein was a member of the Lymphoma Working Group of SWOG, and the Scientific Advisory Boards of both the Lymphoma Research Foundation and the Leukemia and Lymphoma Society.

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Kris Elverum, M.B.A.

Kris Elverum, M.B.A.

SVP of Corporate Development

Kris Elverum has more than 14 years of experience in the pharmaceutical/biotech industry, with expertise in corporate strategy, business development, commercial and operations. He joined Turnstone Biologics from SQZ Biotech, a pre-clinical stage biotechnology company developing cell therapies, where he was Chief Business Officer. Prior to that, he led the U.S. commercial model for CTL019, Novartis’ breakthrough CAR-T cell therapy, and other CAR-T cell immunotherapies. Earlier in his career, he held various commercial roles for Novartis Pharmaceuticals and served as Global Head of Strategy for Sandoz. Before that, he was an Engagement Manager with McKinsey & Co. where he served clients across the healthcare value chain. Kris earned an M.B.A. and a B.S. from the University of Minnesota’s Carlson School of Management.

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Brian Lichty, Ph.D.

Brian Lichty, Ph.D.

SVP, Basic Research

Dr. Brian Lichty is a distinguished scientist with extensive expertise in oncolytic viruses and related immunotherapies, including seminal work with Dr. John Bell at the Ottawa Regional Cancer Centre. He is a professor in the Department of Pathology & Molecular Medicine and the McMaster Immunology Research Centre (MIRC) at McMaster University. Dr. Lichty’s expertise includes influence research in the identification of strategies to leverage oncolytic viruses to harness the patient’s immune system in a sustainable manner, including vaccine design and engineering to directly engage the adaptive immune system tumor-specific and/or to enhance combinations with other immunotherapies. He is also director of the Robert E. Fitzhenry vector lab at McMaster University where clinical-grade viral vaccines are manufactured for human clinical trials. Dr. Lichty earned a Ph.D. from the University of Toronto and a B.Sc. from the University of Guelph.

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David Stojdl, Ph.D.

David Stojdl, Ph.D.

SVP of Discovery Research

Dr. David Stojdl pioneered the exploration of host-virus interactions critical to oncolytic therapy to guide the clinical development of more effective virus platforms. At the Ottawa Regional Cancer Centre, he first identified VSV as an oncolytic virus and defined the archetypal role of interferon signaling in tumor-specific oncolytic virus targeting. Since joining the CHEO Research Institute in 2004, Dr. Stojdl has discovered and developed several novel oncolytic vector platforms, including the Maraba oncolytic virus platform. Dr. Stojdl also directs the CHEO Automated Screening Centre (CASC), leveraging state-of-the-art high-throughput robotic screening technology to uncover new insights for the clinical development of oncolytic virus biotherapies. Dr. Stojdl is a professor in the Department of Pediatrics and Department of Biochemistry, Microbiology and Immunology at the University of Ottawa. He was a scientific co-founder and consultant to Jennerex Biotherapeutics (later acquired by SillaJen Biotherapeutics). He received a Ph.D. from the University of Ottawa and an M.S. and B.S. in microbiology and immunology from the University of Western Ontario.

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Caroline Breitbach, Ph.D.

Caroline Breitbach, Ph.D.

Vice President, Translational Development

Dr. Caroline Breitbach joined Turnstone Biologics from SillaJen Biotherapeutics (formerly Jennerex) where she was Vice President, Clinical and Translational Research. In that position, she oversaw translational and early-stage clinical development of an oncolytic immunotherapy and contributed to lead candidate development from Phase 1 through initiation of Phase 3 evaluation. Previously, she worked in Dr. John Bell’s group at the University of Ottawa, where she evaluated acute effects of oncolytic viruses on the tumor immune microenvironment. She earned a Ph.D. in biochemistry from the University of Ottawa and an Honor’s B.Sc. in microbiology and immunology from McGill University.

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Maura Campbell, Ph.D.

Maura Campbell, Ph.D.

Vice President, Corporate Affairs

Dr. Maura Campbell has spent more than 20 years in technology transfer and the management and commercialization of intellectual property (IP). She has business management experience in all key sectors of biotech, including private and public companies, universities and research institutes, and government-funded public sector research organizations (National Centre of Excellence [NCE]). Maura joined Turnstone Biologics from VBI Vaccines where she served as Director, Intellectual Property. She also was with the Ottawa Hospital Research Institute (OHRI) as a Senior Research Program Manager, where she oversaw the oncolytic vaccine project commercialization. Earlier in her career, Maura was the Director of Intellectual Property for PainCeptor Pharma Corporation, the Manager of Technology Transfer & Commercialization for the OHRI, and the Manager of Technology Transfer at the Institute for Robotics and Intelligent Systems at NCE. She has served as an IP consultant to a number of Canadian start-ups including Neurochem, Conjuchem, Aonix, AMRIC and Sussex Research Labs. Maura received a Ph.D. in biochemistry from the University of Ottawa, and an M.Sc. and a B.Sc. in biochemistry from Queen’s University in Kingston.

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Karen Major

Karen Major

VP of Regulatory

Karen Major has 18 years of Regulatory Affairs experience, specializing in the global development of biotechnological oncology products.  Prior to joining Turnstone, she was Sr. Director Regulatory Affairs at Arbutus Biopharma, focusing on chronic HBV. Prior to that, she held the same position at Tekmira Pharmaceuticals, developing siRNA-LNP products in oncology, infectious disease and metabolic indications. Karen led the Regulatory Affairs departments at YM BioSciences (acquired by Gilead in 2013) and Viventia Biotechnologies. Karen holds an honors BSc in Pharmacology and Toxicology from the University of Toronto, a post-graduate diploma in Regulatory Affairs and Quality Operations from Seneca College, and a Regulatory Affairs Certification (RAC) from RAPS.

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Adina Pelusio

Adina Pelusio

VP of Clinical Operations

Adina Pelusio has more than 15 years of experience in drug development, most recently as the Vice President, Clinical Operations at SillaJen Biotherapeutics (formerly Jennerex, Inc), where she spent a decade advancing oncolytic viruses in clinical trials. In addition to overseeing the Clinical Operations department at SillaJen, she managed and pioneered the medical educator role to expand hospital personnel comfort and knowledge globally with oncolytic viruses. Prior to Jennerex, Ms. Pelusio served as a SWAT Senior Clinical Research Associate at PPD, a large, global CRO, where she was tasked with study rescue and served on a technology committee assigned with developing training for CRAs and project teams on new technologies within the field.

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John Bell, Ph.D.

John Bell, Ph.D.

Ottawa Hospital Research Institute

Dr. John Bell began his independent research career at McGill University before moving to the University of Ottawa and becoming a professor in the Department of Medicine. He is a member of the Center for Innovative Cancer Therapeutics at The Ottawa Hospital Cancer Center and a Senior Scientist at the Ottawa Hospital Research Institute. He heads the Canadian Oncolytic Virus Consortium, a Terry Fox-funded group from across Canada that is developing virus-based cancer therapeutics, and is the Director of the Biotherapeutics Program at the Ontario Institute for Cancer Research. John is the Scientific Director of the National Centre of Excellence for the development of Biotherapeutics for Cancer Therapy and a Fellow of the Royal Society of Canada. Dr. Bell received a Ph.D. from McMaster University and then trained at the Medical Research Council in London, U.K.

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Brian Lichty, Ph.D.

Brian Lichty, Ph.D.

McMaster University

Dr. Brian Lichty is a distinguished scientist with extensive expertise in oncolytic viruses and related immunotherapies, including seminal work with Dr. John Bell at the Ottawa Regional Cancer Centre. He is a professor in the Department of Pathology & Molecular Medicine and the McMaster Immunology Research Centre (MIRC) at McMaster University. Dr. Lichty’s expertise includes influence research in the identification of strategies to leverage oncolytic viruses to harness the patient’s immune system in a sustainable manner, including vaccine design and engineering to directly engage the adaptive immune system tumor-specific and/or to enhance combinations with other immunotherapies. He is also director of the Robert E. Fitzhenry vector lab at McMaster University where clinical-grade viral vaccines are manufactured for human clinical trials. Dr. Lichty earned a Ph.D. from the University of Toronto and a B.Sc. from the University of Guelph.

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David Stojdl, Ph.D.

David Stojdl, Ph.D.

University of Ottawa

Dr. David Stojdl pioneered the exploration of host-virus interactions critical to oncolytic therapy to guide the clinical development of more effective virus platforms. At the Ottawa Regional Cancer Centre, he first identified VSV as an oncolytic virus and defined the archetypal role of interferon signaling in tumor-specific oncolytic virus targeting. Since joining the CHEO Research Institute in 2004, Dr. Stojdl has discovered and developed several novel oncolytic vector platforms, including the Maraba oncolytic virus platform. Dr. Stojdl also directs the CHEO Automated Screening Centre (CASC), leveraging state-of-the-art high-throughput robotic screening technology to uncover new insights for the clinical development of oncolytic virus biotherapies. Dr. Stojdl is a professor in the Department of Pediatrics and Department of Biochemistry, Microbiology and Immunology at the University of Ottawa. He was a scientific co-founder and consultant to Jennerex Biotherapeutics (later acquired by SillaJen Biotherapeutics). He received a Ph.D. from the University of Ottawa and an M.S. and B.S. in microbiology and immunology from the University of Western Ontario.

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Brad Bolzon, Ph.D.

Brad Bolzon, Ph.D.


Dr. Brad Bolzon is a Managing Director at Versant Ventures and on the biotech investment team. He has more than 13 years of global pharmaceutical industry experience. He specializes in early-stage biotech investing with a particular emphasis on new company start-ups. Prior to joining Versant, Brad served as Executive Vice President, Global Head of Business Development, Licensing & Alliances for F. Hoffmann-La Roche. Under his leadership, Roche established alliances with more than 75 biotech companies worldwide and significantly strengthened its product pipeline. Previously, Brad held executive roles at Eli Lilly in drug discovery, clinical research, regulatory affairs, and business development.

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Jerel Davis, Ph.D.

Jerel Davis, Ph.D.


Dr. Jerel Davis is a Managing Director at Versant Ventures and is based in Vancouver. Since joining Versant in 2011, he has played a critical role in launching and investing in a number of Versant’s portfolio companies including Quanticel Pharmaceuticals, Crispr Therapeutics, Blueline Bioscience, Northern Biologics and several of the Inception Sciences discovery start-ups. He has also led Versant’s execution of build-to-buy structured acquisitions with Celgene, Roche and Bayer. Over the last few years, Jerel has focused on establishing Versant’s presence in Canada, including the launch of new companies in Vancouver, Toronto and Montreal. Prior to joining Versant, Jerel was Associate Principal at McKinsey and Company where he advised pharmaceutical, biotechnology, medical device and molecular diagnostics companies. He has worked in a number of healthcare markets globally including the United States, Europe, China, Russia and India. Jerel was a post-doctoral researcher at Stanford University and worked in research at Amgen.

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Rishi Gupta, J.D.

Rishi Gupta, J.D.


Rishi Gupta is a private equity partner at OrbiMed. Prior to that, he was a healthcare investment banker at Raymond James & Associates, served as manager of corporate development at Veritas Medicine and was a summer associate at Wachtell, Lipton, Rosen & Katz. Rishi has published scientific articles on the mechanisms of HIV entry into host cells and legal articles on intellectual property laws in the developing world. In addition to Turnstone Biologics, he serves or has served on the boards of Dimension Therapeutics, Symbiomix Therapeutics, Avitide, Verona Pharma, ChemoCentryx and Sientra. He has also been actively involved with OrbiMed’s investments in Acceleron Pharma, CoGenesys, Supernus Pharmaceuticals, Adimab, Receptos, Aragon Pharmaceuticals, Seragon Pharmaceuticals, Alector, Arsanis, Biotie, Invitae and ORIC Pharmaceuticals. Rishi earned a J.D. from the Yale Law School and an A.B. degree magna cum laude in biochemical sciences from Harvard College.

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Sammy Farah, Ph.D., M.B.A.

Sammy Farah, Ph.D., M.B.A.


Dr. Sammy Farah has extensive vaccine expertise and almost 20 years of scientific, business and executive management experience in the biotechnology industry. He joined Turnstone Biologics from Synthetic Genomics Vaccines, Inc., where he served as President. Prior to that, he was Chief Business Officer of Immune Design Corp. And before then, Sammy was at Versant Ventures where he specialized in biotechnology investing and new company formation, and at Merck & Co., Inc. where he led technology support for multiple commercial vaccine franchises before joining the business development and licensing group to evaluate and execute new external technology and research partnerships. Dr. Farah earned an M.B.A. from the Wharton School at the University of Pennsylvania, a Ph.D. in biochemical engineering from Stanford University, and a B.S. in biochemical engineering from the Massachusetts Institute of Technology.

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Patrick Machado

Patrick Machado


Patrick Machado is a co-founder of Medivation, Inc., a biopharmaceutical company, and has served on its Board of Directors since April 2014. Prior to his retirement in April 2014, Mr. Machado served as Medivation’s Chief Financial Officer since its inception in September 2003 and as its Chief Business Officer since December 2009. From 1998 until 2001, Mr. Machado was employed by ProDuct Health, Inc., a privately-held medical device company, as Vice President, Chief Financial Officer and General Counsel from 1998 to 2000, and as Senior Vice President and Chief Financial Officer from 2000 to 2001. From 2001 until 2002, Mr. Machado served as a consultant to Cytyc Corporation, to assist with transitional matters related to Cytyc Corporation’s acquisition of ProDuct Health, Inc. Mr. Machado received a J.D. from Harvard Law School and a B.A. and B.S. in German and Economics, respectively, from Santa Clara University.

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Robert Gould

Robert Gould


Robert Gould joined Fulcrum as president and CEO at the time of the company’s launch in 2016, bringing over 30 years of experience to the role. Previously, he served as president and CEO of Epizyme from 2010 to 2015. Prior to joining Epizyme, Robert served as director of novel therapeutics at the Broad Institute of MIT and Harvard from 2006 to 2010. Robert spent 23 years at Merck where he held a variety of leadership positions, culminating in the role of vice president, licensing and external research. Throughout his time at Merck, Robert was instrumental in advancing more than 20 compounds from discovery into clinical development in multiple therapeutic areas. Robert received a B.A. from Spring Arbor College and a Ph.D. from the University of Iowa and completed postdoctoral studies at the Johns Hopkins University.

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Stefan Larson, Ph.D.

Stefan Larson, Ph.D.


Dr. Larson joined Sectoral in 2018 as Partner – Private Equity, responsible for leading biotechnology private equity investments. Prior to joining Sectoral, Dr. Larson was an Entrepreneur-in-Residence and later Venture Partner with Versant Ventures, where he led the establishment of their Toronto-based Discovery Engine and was the founding CEO of Northern Biologics. Dr. Larson was also a co-founder of two medical device companies: Perimeter Medical Imaging, and Tornado Spectral Systems. He began his career at McKinsey & Company in San Francisco and Toronto. Dr. Larson received his B.Sc. in Biology from McGill University, and his M.Sc. in Molecular and Medical Genetics from the University of Toronto, prior to completing his Ph.D. in Biophysics at Stanford University.

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Jeff Courtney

Jeff Courtney

In Memoriam

Jeff Courtney helped to form Turnstone Biologics and was an outstanding leader for FACIT (Fight Against Cancer Innovation Trust). Jeff’s life’s work and warm personality inspires all of us at Turnstone Biologics to drive forward our mission to help cancer patients, and we greatly miss his presence, leadership and friendship.

We are backed by top-tier investors who are committed to the company’s growth. We have raised approximately $50 million in venture capital financing since our inception.

Turnstone Biologics views strategic partnerships as a core component of our strategy and is interested in collaborating with biopharma companies, academic centers, and universities to transform patient care.

In the fall of 2017, Turnstone Biologics entered into a strategic research, option and license agreement with AbbVie for our Ad-MG1-MAGEA3 therapy and two research-stage candidates that are presently in development.

Careers

Turnstone Biologics’ team works with a sense of urgency to fulfill our mission. Our decision-making is driven by science and our therapeutics are designed with the patient in mind.

We value transparency, innovation, integrity and purpose as we collaborate to transform cancer care. If you’re a passionate person, and our mission and science excite you, Turnstone Biologics might be for you.

Team Member Openings

Turnstone Biologics is dedicated to excellence and innovation in every aspect of our science and business. We are actively looking for exceptional individuals who share our passion for developing and delivering next-generation viral immunotherapies. We offer competitive compensation and benefits and are an equal opportunity employer.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies harness anti-tumor immunity by combining the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine. Our robust pipeline of early-stage biologics, based on our MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses. Turnstone continues to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, and Hamilton, Canada and New York, USA.

Position Overview:

The Lab Operations Manager (Temporary) is responsible for overseeing the day-to-day operations of the local R&D group. Responsibilities include sourcing and procurement of all lab consumables and equipment, managing logistics and maintaining communication with all team members to support their activities and enhance productivity. The Lab Operations Manager will apply technical expertise to inform decision-making and coordinate with Scientists to prioritize objectives. Administrative responsibilities include document control for the local R&D group, selection and management of vendors, management of equipment and facility maintenance, biological and consumable inventories, budgeting, invoice approvals and site-specific staff on-boarding. The Lab Operations Manager is responsible for maintaining a safe work environment in compliance with health and safety regulations. They will develop SOPs and support staff training requirements for the local R&D group. The Lab Operations Manager will coordinate with internal stakeholders, vendors and collaborators. They will manage projects in response to and in support of the evolving needs of the company, which will involve coordination of stakeholders and management of budget and timeline.

Experience & Qualifications:

  • 5 years experience in an industrial laboratory
  • Must have good analytical and problem-solving abilities
  • Self-starter with a strong work ethic and attention to detail
  • Knowledge and experience with standard software (e.g. LIMS, Microsoft Office Suite, Graphpad Prism)
  • Knowledge and commitment of Occupational Health and Safety Procedures in a laboratory.

 To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being part of a dynamic team of  key “go-to” biomarker and assay professionals, then this role may be for you!  Your role will be to drive/support/contribute to the implementation of the clinical biomarker strategy for multiple therapeutics.  You will have experience working with some or all the following, as they relate to Biomarker duties:

  • Manage the development of companion diagnostics in collaboration with appropriate vendors and other stakeholders
  • Select centralized testing vendors and assays to best investigate the clinical biomarkers and mechanism-of-action questions
  • Oversee assay development and validation of assays at CROs
  • Oversee implementation of clinical trial assays at centralized testing vendors
  • Remain up to date on new technologies, methods, and regulatory expectations
  • Perform data analysis of various assays, which could include (but is not limited to) virus plaque assays, RT-qPCR and RT-PCR, western blots, IHC, immunoassays (ICS, ELISPOT), neutralizing antibody assays, NGS, RNAseq, among others
  • Draft reports for internal and external stakeholders
  • Review, summarize, document, and prepare data for databases and formal reports
  • Trend data on per patient and per group basis to discover meaningful correlations and trends
  • Draft regulatory documents for biomarker and companion diagnostics
  • Maintain knowledge of applicable regulatory requirements and relevant scientific/technical issues
  • Generate and maintain clinical SOPs and SOWs to support technical work at sites
  • Manage contracts, budgets and timelines
  • Maintain involvement in a wide spectrum of R&D functions including evaluation of drug candidates and clinical biomarker research

The details

This role is best suited for a some with the following:

  • PhD in immunology, virology or other related disciplines
  • At least 5 years of pharma research-related experience (individuals with considerable academic experience will be considered)
  • Experience and knowledge with some of the following assays: virus plaque assays, RT-qPCR and RT-PCR, western blots, IHC, immunoassays (ICS, ELISPOT, flow cytometry), nAb assays, NGS, RNAseq, among others
  • Experience in development and validation of clinical assays at CROs.
  • Experience with outsourcing and monitoring of clinical assays
  • Excellent analytical, technical writing, and data management skills
  • Excellent working knowledge of Microsoft Office, including Word, Excel, PowerPoint, Outlook
  • Excellent written and oral communication skills
  • Strong ability to work closely with several disciplines within a small company, displaying innovative thinking, motivation, and accountability
  • Good planning and organizational skills
  • Able to multi-task, react, and adapt to changing priorities
  • Attention to detail
  • Well-developed interpersonal skills
  • Ability to travel as required

Asset qualifications:

  • Companion diagnostic experience in oncology considered a strong asset
  • Knowledge and experience in virology, oncology, and immunology is preferred

To Apply:
Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

 

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies harness anti-tumor immunity by combining the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine. Our robust pipeline of early-stage biologics, based on our MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses. Turnstone continues to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, and Hamilton, Canada and New York, USA.

Position Overview:

Reporting to the Sr. Scientist in Ottawa, the position of Research Technician is responsible for supporting the testing of novel oncolytic vaccine constructs to contribute to Turnstone Biologics growing pre-clinical pipeline.

Our company’s technology is based around replicating oncolytic virus vaccines engineered to target tumours and launch massive tumour targeting immune responses.  The core of this technology lies in the designing and building of these genetically constructed viruses.  Your role will be to join a team of immunologists and molecular biologists who engineer and test these nanomedicines for preclinical and clinical development.  There will be additional opportunities to work with our CMC team and other R&D members to continually refine the technology and manufacturing process for this class defining technology. If you have experience with manual, or robotic automation of, cell based and biochemical assays including ELISA, ELISpot assay, PCR and/or mammalian cell culture, are meticulous and driven to achieve; then this opportunity may be just what you are looking for.

The Research Technician will work along side senior researchers and project teams and participate in designing and executing cell-based immunology and virology assay following established laboratory standard operating procedures (SOPs).  The incumbent is expected to prepare data/figures to report directly to senior research staff in support of multiple projects. Additional responsibilities will include inventory management; organize freezers; routine maintenance; calibration and troubleshooting on laboratory equipment.  We have an open, transparent and dynamic culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.

Experience & Qualifications:

  • MSc, BSc or community college diploma plus 2-3 years’ experience in an academic or industrial laboratory or combination of education and experience.
  • Expert in mammalian cell-based and biochemical experimentation
  • Must have good analytical and problem-solving abilities
  • Robotic automation experience preferable
  • Self-starter with a strong work ethic and attention to detail
  • Knowledge and experience with standard software (e.g. LIMS, Microsoft Office Suite, Graphpad Prism)
  • Knowledge and commitment of Occupational Health and Safety Procedures in a laboratory.

 To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:

The position is located in Ottawa and Hamilton reporting to the SVP and/or Group Leader.  The position of Scientist/Immunologist is to manage all aspects of the discovery, validation and preclinical development to advance a novel neoantigen immunotherapy from the discovery phase into the clinic.  The incumbent will demonstrate their ability to participate in a highly matrixed and innovative research environment with a track record of translating basic research findings into novel therapeutic strategies that support clinical drug development.  They will contribute to the technical development and testing of a first-in-class personalized immunotherapy, meshing tumour genomics with individualized vaccine construction.  The position contributes both intellectually and experimentally as part of a multidisciplinary team with the development of strong cross-functional relationships being important for success.

Responsibilities:

  • Conduct research and design experiments that focus work in tumor and immune cell target identification/validation leading to innovative next generation biologics and modalities.
  • Utilize expertise to independently design, execute and analyze experiments using cellular and molecular immunological assays to investigate and uncover novel target biology and technologies to foster neoantigen targeted immunotherapy.
  • Effectively collaborate with other members of the company, including external collaborators and partners.
  • Prepare and present hypotheses, on-going progress reports, technical reports and future plans (including contributing to budget strategic presentations).
  • Supervise students and/or laboratory and research technicians in equipment management (e.g., flow cytometer) and ethical treatment of animals in research.
  • Contribute to building a culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.

Experience & Qualifications:

  • Must hold a Ph.D. in biology/immunology/oncology/pharmacology or a related field with 5+ years of experience or an acceptable combination of education and experience.
  • Robust understanding of innate and adaptive immune systems is required.
  • Experience with in vivo models, isolation and culture of primary cells (both mouse and human).
  • National Institutional Animal User Training Certification (NIAUT) an asset.
  • A working knowledge of immune based in vitro assays, flow cytometry and common molecular techniques.
  • Experience in T cell function/differentiation/signaling/regulation, phenotypic analysis of inhibitory and costimulatory targets and pathways and/or neoantigen biology and vaccines is highly preferred.

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another day at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

Our Bioprocess Development and Manufacturing Sciences (PD&MS) team within the overall Technical Operations department is growing. As an Associate Scientist on the PD&MS team, you will report to the Process Development Engineer responsible for leading all of the upstream process development activities, like cell line and media development, optimization of cell culture, bioreactor engineering and virus manufacturing. The responsibilities for this position span across our multi-virus platform and include:

· Study design, planning and implementation to drive process development activities to include protocol design, data analysis, and report writing.
· Building and maintaining data-rich batch analysis to enable data interpretation and ongoing trending
· Communicating study findings at internal Technical Operations meetings, and to external stakeholders via powerpoint presentation of the analyzed data
· Technology transfer of process development successes to larger scale and GMP
· Cell line and cell train development to fit to new bioreactors, reduce the use of animal-derived additives, and enable high virus productivity from cells
· Optimize virus infection and harvest conditions to ensure maximum productivity per cell
· Building and utilizing process engineering knowledge and analyzing processes to identify areas for improvement
· Conduct research on literature, new technologies and process data to offer insight and direction with regards to upstream process development approaches and findings

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportinites for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience & Qualifications:

    The Associate Scientist will be positioned in our Ottawa, Canada office Head Quarters
    A Bachelor’s of Science (BSc) and Master’s degree in one of these related fields: virology, biochemistry, or molecular biology (PhD considered an aasset)
    Virology focused post-graduate degree highly desirable
    Strong knowledge of virology, mammalian cell culture, viral molecular biology and/or virus processing/manufacture is required
    3+ years of experience post-education working in Industry, academia, or research laboratory
    Experienced and confident in presenting data to key stakeholders and external partners
    Innovative thinker with a proven track record of designing complex yet targeted experiments to answer key questions
    Analytical minded individual with the ability to investigate technically challenging problems
    Mature interpersonal skills and a communication style that matches the Turnstone style: respectful, transparent, and constant
    Excellent computer skills, including Microsoft Excel and Powerpoint
    Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency and function effectively in a fast-paced and dynamic environment
    Able to manage competing priorities effectively and adapt to changing priorities

    To Apply:

    Please click here to apply!

    Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

Position Overview:

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another day at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

The Analytical Development and Quality Control team is growing. The responsibilities for this position span across our multi-virus platforms and will touch several teams across the company:

• Lead all communication with our global network of Contract Testing Organizations (CTOs) to manage timelines, resources, and priorities
• Escalate issues to subject matter experts when required and enable key technical discussions
• Coordinate all meetings, track action items, and manage testing submissions
• Maintain a master Study Log that tracks study execution milestones to support the Tech Ops PMO for budgetary tracking
• Coordinate, prioritize, and support all non-GMP testing across our external testing network in collaboration with the Tech Ops PMO logistics team
• Support AD/QC team with developing and managing development timelines, risk communication and mitigation strategies in collaboration with the PMO

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution. With our company size and growth, we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader. Passionate about being a part of a critical function of a growing company and continuous learning? We will have plenty of that for you!

We are in the early stages of building strategies, structures, and process so this role will be busy and expanding. You’ll use your strong organizational and multi-tasking skills to support critical analytics across the company, all the while learning about analytical development and quality control. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

Experience & Qualifications:

    • The Analytics Technical Coordinator will be positioned in our Ottawa, Canada office Head Quarters
    • Strong desire and ability to learn about analytics in the biotech field and to contribute to team goals
    • Basic knowledge of molecular biology, cell biology, or virology
    • Bachelor’s degree in a related Science field, with an advanced degree considered an asset
    • Experience within the biotech/pharmaceutical industry would be considered an asset
    • Ability to multi-task and manage several competing priorities
    • Attention to detail and highly organized
    • This is a role that requires constant interface with, and representation of, the team. The candidate must have mature interpersonal skills, and a communication style that matches the Turnstone style: respectful, transparent, and team-oriented
    • Excellent computer skills, including Microsoft Excel and Powerpoint
    • Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency and function effectively in a fast-paced and dynamic environment
    • Experience building project timelines using Gantt software considered an asset

    To Apply:

    Please click here to apply!

    Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

 

If you are interested in being a part of a growing Analytical Development & Quality Control team, then this role may be for you! As an Associate Scientist, Analytical Development, you will be responsible for designing, developing, and qualifying assays to support any number of functions within the technical operations scope:  process development, formulation development, product characterization, raw material testing, and GMP product release and stability testing.  You will regularly interact with other Turnstone team members to establish needs, help with result analysis, and transfer well-established analytical methods. Your role will be to work directly with the lead Scientist for Analytical Development of molecular biology assays.  This role will involve some wet bench work to troubleshoot and optimize assays, through well-thought out experiments.  You will have experience working with some or all the following, as they relate to the Associate Scientist, Analytical Development duties:

  • Designing and executing experiments precisely and carefully to drive development and optimization activities for molecular assays
  • Developing and/or qualifying analytical assays suitable for characterization, in-process testing, final drug-product release, and/or product stability
  • In-depth experience with various molecular methods such as:  (q)PCR, sequencing, picogreen, nucleic acid extractions from various matrices, electrophoresis, etc
  • Trending analytical metrics to confirm method reproducibility and consistency.  Experience with meta-analysis an asset
  • Writing and reviewing protocols and reports describing analytical assays contributing to regulatory filings
  • Transferring methods to other internal or external partners and supporting the collaboration through timely result analysis
  • Communicating analytical results in a timely manner and collaborating with internal and external development teams to support their goals and timelines
  • Managing multiple tasks and changing priorities in a fast-paced environment
  • Communicating effectively to peers and leadership to support decision-making, including writing protocols and summarizing results in a report or presentation.

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution.  With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader.  Passionate about being a part of a critical function of a growing company and continuous learning?  We will have plenty of that for you!

We are in the early stages of building strategies, structures, and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The Details

This role is best suited for someone with the following:

  • 2+ years of overall experience within the biotech/pharmaceutical industry in a laboratory setting performing molecular methods
  • Proven ability to apply advanced analysis principles, theories, and concepts to solving complex problems associated with drug development
  • In depth experience in a variety of cGMP laboratory activities and analytical techniques applied to the testing of viral-based products
  • Strong ability to critically review, evaluate, and interpret analytical results (including stability data) and support investigations to resolve analytical issues
  • Working knowledge of GMP regulations and FDA guidance applicable to biologics and immuno-therapy manufacturing
  • Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency and function effectively in a fast-paced and dynamic environment
  • Strong organizational skills to prioritize and manage multiple time-sensitive projects simultaneously
  • A self-starting attitude: you work independently and effectively, with little oversight or management
  • Advanced degree (M.S., Ph.D.) in molecular biology or related discipline
  • Experience working in a fast-growing start-up environment strongly preferred

This role will be based in Ottawa, Ontario.

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title Associate Scientist, Analytical Development Chemistry Assay.

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being a part of a growing Analytical Development & Quality Control team, then this role may be for you! As an Associate Scientist, Analytical Development, you will be responsible for designing, developing, and qualifying assays to support any number of functions within the technical operations scope:  process development, formulation development, product characterization, raw material testing, and GMP product release and stability testing.  You will regularly interact with other Turnstone team members to establish needs, help with result analysis, and transfer well-established analytical methods. Your role will be to work directly with the lead Scientist for Analytical Development of cellular biology assays.  This role will involve some wet bench work to troubleshoot and optimize assays, through well-thought out experiments.  You will have experience working with some or all the following, as they relate to the Associate Scientist, Analytical Development duties:

  • Designing and executing experiments precisely and carefully to drive development and optimization activities for cellular assays
  • Developing and/or qualifying analytical assays suitable for characterization, in-process testing, final drug-product release, and/or product stability
  • In-depth experience with various cellular methods such as:  plaque assay and TCID50s, ELISA, Western blot, Bradford assay, viral killing potency assay, etc
  • Trending analytical metrics to confirm method reproducibility and consistency.  Experience with meta-analysis an asset
  • Writing and reviewing protocols and reports describing analytical assays contributing to regulatory filings
  • Transferring methods to other internal or external partners and supporting the collaboration through timely result analysis
  • Communicating analytical results in a timely manner and collaborating with internal and external development teams to support their goals and timelines
  • Managing multiple tasks and changing priorities in a fast-paced environment
  • Communicating effectively to peers and leadership to support decision-making, including writing protocols and summarizing results in a report or presentation.

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution.  With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader.  Passionate about being a part of a critical function of a growing company and continuous learning?  We will have plenty of that for you!

We are in the early stages of building strategies, structures, and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The Details

This role is best suited for someone with the following:

  • 2+ years of overall experience within the biotech/pharmaceutical industry in a laboratory setting performing cellular biology methods
  • Proven ability to apply advanced analysis principles, theories, and concepts to solving complex problems associated with drug development
  • In depth experience in a variety of cGMP laboratory activities and analytical techniques applied to the testing of viral-based products
  • Strong ability to critically review, evaluate, and interpret analytical results (including stability data) and support investigations to resolve analytical issues
  • Working knowledge of GMP regulations and FDA guidance applicable to biologics and immuno-therapy manufacturing
  • Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency and function effectively in a fast-paced and dynamic environment
  • Strong organizational skills to prioritize and manage multiple time-sensitive projects simultaneously
  • A self-starting attitude: you work independently and effectively, with little oversight or management
  • Advanced degree (M.S., Ph.D.) in cellular biology or related discipline
  • Experience working in a fast-growing start-up environment strongly preferred

This role will be based in Ottawa, Ontario.

To Apply: Please click here to apply!

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title Associate Scientist, Analytical Development.

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.  If you are interested in being a part of a growing team, then this role may be for you! The Project Coordinator will mainly be responsible for capturing and integrating technical operations related activities across multiple programs and coordinating those activities to ensure project goals are met.

You will have experience working with some or all the following, as they relate to the Project Coordinator duties:

  • Develop timelines, coordinate execution of activities for all elements related to process development, assay development and production of non-GMP material (SOW, contracts, NDA/CDA, approval of invoices, maintaining inventory of material and Turnstone equipment)
  • Support testing (GMP and non-GMP) and logistics activities as needed
  • Closely monitor/control project progression to ensure project deadline are met
  • Reports project progress to key stakeholders
  • Serves as liaison with client contacts and organizes project team meetings
  • Represents company in project meetings, prepares meeting agenda and minutes, and follows up on action items
  • Ensure effective communication, cooperation and trust with client
  • Work closely with team members across all Technical Operations related business units to ensure coordination of all efforts and real-time communication with all stakeholders

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution.  With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader.  Passionate about Tech Ops and continuous learning?  We will have plenty of that for you! 

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The details

This role is best suited for a some with the following:

  • This work requires attention to detail and accuracy
  • High degree of organizational skills is required
  • Excellent written and oral communication skills
  • Must demonstrate initiative and ability to work independently to resolve issues.
  • Ability to work on tight deadlines
  • Ability to set up and maintain detailed tracking data bases while continuously reviewing and updating inventories
  • Ability to multi-task and coordinate project activities through completion
  • Well-developed interpersonal and client relationship building skills
  • Strong ability to work closely with all disciplines within a small company, displaying innovative thinking, motivation, and accountability
  • Excellent working knowledge of Microsoft Office, including Word, Excel, PowerPoint, and Outlook
  • Knowledge of project management software (MS Project, Merlin)
  • Previous experience in coordinating multiple projects
  • Experience coordinating process development activities is considered to be an asset
  • Knowledge of cGxP
  • A degree in Biology, Biotechnology, or related field is preferred
  • Must be able to travel (domestic, international)

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title Tech Ops Project Coordinator.

 Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being a part of a growing Manufacturing Sciences team, then this role may be for you! As an Associate Scientist/Engineer, Manufacturing Sciences, you will report to Manufacturing Sciences lead, within the Bioprocess Development and Manufacturing Sciences team. With responsibilities spanning across our multi-virus platform, key duties as they relate to this role will include:

  • Batch Analysis, data trending, and presentation preparation of the trended data
  • Master Batch Record review, and field copy review
  • Tracking and trending of deviations and investigations
  • Performing risk assessments across a varity of process, manufacturing, and equipment challenges
  • Participate in the equipment selection, procurement, and validation process

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution.  With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader.  Passionate about being a part of a critical function of a growing company and continuous learning?  We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The Details

This role is best suited for someone with the following:

  • 1-2 years of overall experience within the biotech/pharmaceutical industry
  • Bachelors degree in Science / Engineering, with a Master’s degree considered an asset.
  • Trained in one of the following fields: chemical engineering, biology, biochemistry, or virology
  • Basic knowledge of cell biology, and virology
  • Excellent computer skills, including Microsoft Excel, PowerPoint, and Jump
  • Excellent data analysis capabilities including statistical methods
  • Enjoy data mining, trending, and graphing data for presentation within reports or at meetings
  • Excellent written communication skills to enable drafting of reports, and risk assessments
  • Previous experience drafting or reviewing Batch Records considered an asset
  • Knowledge of GMPs considered an asset
  • Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency and function effectively in a fast-paced and dynamic environment

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title Associate Scientist/Engineer, Manufacturing Sciences.

 Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being a part of a growing Technical Operations team, then this role may be for you! As the Manager of Downstream Drug Substance Development, you will provide leadership, plan, direct, and coordinate all Downstream Process Development efforts to support our viral-based platforms. Reporting to the Director of Bioprocess Development & Manufacturing Sciences, you and your team will lead all aspects of virus based purification techniques, including chromatography, UF/DF, clarification and filtration. The responsibilities include the following:

  • Manage portfolio of viral and non-viral cancer immunotherapy products for all downstream process development
  • Potential to lead a team of 3+ engineers by mid-2020 for all Downstream process development
  • Process ranging from Phase I start up, through Phase III readiness and strategy for process improvements of clinical-stage programs
  • Direct downstream bioprocess development work in partner labs, including a network of 4-6 experienced CDMO partners
  • Definition and process characterization to refine CPPs with line of sight for process validation
  • Present trended data, and recommendations in a cross functional Project Team
  • Travel required, 10 – 15%
  • Participation in regulatory strategy and document authoring/reviewing for interactions with FDA, EMA, and Health Canada

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution.  With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader.  Passionate about being a part of a critical function of a growing company and continuous learning?  We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportinites for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The Details

This role is best suited for someone with the following:

  • 7+ years of overall experience within the biotech/pharmaceutical industry Scientist or Engineer with advanced degree (MSc or PhD)
  • Educated in one of the following fields: chemical engineering, biochemistry, virology
  • SME of virus based purification techniques
  • Experience trouble-shooting new processes, and taking processes from early phase clinical development through validation
  • Experience in a small company, preferred (BioTech / Start up experience)
  • Strong interpersonal skills, and ability to manage several competing priorities
  • Leadership experience preferred

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being a part of a growing Analytical Development & Quality Control team, then this role may be for you! As the Quality Control team leader (title dependent on experience), you will provide leadership, plan, and  direct the Quality Control testing and review of engineering and GMP product lots for characterization , product release testing, and stability programs. You will drive the development and maintaining of Quality Control policies and ensure quality and compliance in the Quality Control laboratories. Your role will be to work directly with the Leader of Analytical Development and Quality Control and be responsible for the supervision of daily operations of the Quality Control team, managing the product lot release and stability programs including trending, scheduling, training, troubleshooting to ensure all operations are in full compliance with applicable SOPs, safety, and regulatory guidelines. You will have experience working with some or all the following, as they relate to the Manager of Quality Control duties:

  • Lead and manage the day to day activities of quality control operations and ensure the efficiency and effectiveness of activities related to product characterization, product lot release testing, stability testing, and analytical method validation
  • Stay up to date on global QC regulatory requirements (EU, US, Canada) and expectations with regards to lot release testing, raw material testing, and stability programming and ensure that our programs are compliant.
  • Assist in the design, implementation, and continuous improvement of Quality Control systems that are technically sound, promote effective and efficient operations, and comply with GMP requirements
  • Ensure QC test data and drug product CoA are reviewed and available for drug product release.
  • Perform tracking and trending of analytical data from the Quality Systems and assist in writing and reviewing periodic reports
  • Work independently to review and trend QC data, generating stability and other trending reports as necessary
  • Lead a team of QC scientists, supporting them in their duties to execute the lot release programs and the stability programs for several complex viral biologic agents.
  • Support QC deviations, investigations, analytical method performance trending.
  • Reviews manufacturing, environmental monitoring, and quality control data for in-process and finished products as part of the investigation process
  • Identify and mitigate risks in QC laboratory that could negatively impact the safety, identity, strength, purity, or quality of the product
  • Create and approve relevant Standard Operating Procedures (SOP) as needed
  • Act as subject matter expert for QC GMP operations during diligence and regulatory interactions

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution.  With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader.  Passionate about being a part of a critical function of a growing company and continuous learning?  We will have plenty of that for you! 

We are in the early stages of building strategies, structures, and process so this role will be busy and expanding. We also have opportunities for you to be a mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The Details

This role is best suited for someone with the following:

  • 7+ years of overall experience within the biotech/pharmaceutical industry with a majority of the experience focused in Quality Control or related area
  • Direct experience supporting the testing of GMP products with a minimum of 3 years of managerial experience is required
  • Experience in a QC role in an early clinical phase to phase 3 biotech organization is highly preferred
  • Experience working with external partners to support manufacturing, testing, and product distribution
  • Experience working closely with cross-functional teams within an organization to achieve goals in a timely and efficient manner
  • Strong working knowledge of GMP regulations and FDA guidance applicable to biologics and immuno-therapy manufacturing
  • Self-motivated and efficient, able to manage responsibilities with an appropriate sense of urgency and function effectively in a fast-paced and dynamic environment
  • Strong organizational skills to prioritize and manage multiple time-sensitive projects simultaneously;
  • Exceptional project management skills with the ability to multi-task, prioritize, and meet deadlines in a fast-paced environment.
  • A self-starting attitude. You work independently and effectively, with little oversight or management.
  • Bachelor of Science degree or Postgraduate degree in Cell Biology, Molecular Biology, Biochemistry, Microbiology, or a related discipline. Bachelor’s degree should be supplemented with additional year of work experience.
  • Experience working in a fast-growing start-up environment strongly preferred.

To Apply:

Please forward applications via email only to hr@turnstonebio.com including a cover letter and resume. In the e-mail subject line, please indicate the position title Manager, Quality Control.

 Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies harness anti-tumor immunity by combining the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine. Our robust pipeline of early-stage biologics, based on our MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses. Turnstone continues to build a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, and Hamilton, Canada and New York, USA.

We are currently seeking a highly qualified, motivated and experienced individual for the position of Assistant Controller, reporting to the Vice President of Finance and will interact with the Chief Financial Officer and all levels of management and third-party vendors. The ideal candidate is a licensed CPA with biotechnology or pharmaceutical experience.

This position will have accountability and responsibility for aspects of the company’s financial reporting requirements including IPO readiness and potential SEC filings (coordinate the preparation of close packages amongst key stakeholders to ensure accuracy and quality of financial statements and disclosures), risk management, variance analytics, addressing technical accounting issues arising from business transactions and manage and grow a team. This candidate will primarily be responsible for meeting each month-end close, this candidate is responsible for accounting entries requiring high accounting acumen (i.e. revenue and stock compensation expense).

The Assistant Controller will oversee integration of new accounting pronouncements. This position will also assist in building the infrastructure, processes and controls to achieve SOX compliance. This includes working with IT to utilize existing financial systems in the most effective manner to develop scalable and efficient accounting processes.

This individual frequently interacts with accounting staff, IT, HR, Legal, International Operations (travel necessary for close at first) and other key stakeholders across the organization as well as external auditors. This role requires critical thinking skills, effective organizational skills, excellent written and verbal communication skills, and a strong ability to build effective relationships across the Company.

RESPONSIBILITIES

  • Manage external reporting process, working with accounting, FP&A and consultants; assist in gathering data from key stakeholders to prepare schedules and analytics
  • Responsible for leading and managing aspects of month end close, technical accounting, equity accounting, Stock option & ESPP, purchase to pay and payroll cycle
  • Work with external auditor to manage the audit process
  • Responsible for managing staff and review of full purchase to pay cycles and payroll cycle
  • Prepare and communicate the quarterly close reporting calendar, which involves coordinating key timelines and deliverables to the external auditors, legal team, tax partner and senior mgmt.
  • Manage the timely and accurate preparation, review and filing of all external financial reports, including those potentially filed with the SEC on Form 10-Q, 10-K and 8-K and associated consolidated financial statements, footnotes, management discussion and analysis
  • For the Company’s financial statements, prepare disclosure checklists and disclosure meeting presentations, ensure the filings are properly formatted and accurate and perform XBRL tagging
  • Comply with internal controls related to the SEC reporting process in support of management’s and the external auditors’ assessment of internal controls over financial reporting
  • Staying abreast of new accounting principles, SEC reporting and general trends within the financial services industry
  • Develop and own tax function working with external consultant
  • Assess quarterly transactions for disclosure, perform technical accounting and IRS ruling research, draft memos
  • Coordinates/monitors/reviews the execution of key processes including those in support of management’s assessment of internal controls over financial reporting in accordance with the COSO Framework and Sarbanes-Oxley Act (SOX)
  • Ensures integrity of the company’s accounting system, including new account, department and project set-up, financial report development and maintenance, and interfaces between payroll, equity, financial planning and expense management systems to the general ledger
  • Provides support to all other teams across the company as needs arise, including special projects, system improvements or ad-hoc financial analyses as assigned

QUALIFICATIONS/SKILLS REQUIRED

  • 8+ years of relevant experience (biotech/pharma industry preferred)
  • Active CPA (Big four audit experience preferred)
  • Strong knowledge and understanding of US GAAP and SEC Regulations.
  • Proficiency in Excel and Word and ability to learn new systems quickly are required
  • An independent problem-solver with strong work ethics and intellectual curiosity will thrive
  • Attention to detail, ability to multi-task, and strong interpersonal skills including verbal and written communication are essential in this collaborative work environment
  • Requires strong leadership and diplomacy skills to guide teams and facilitate collaboration
  • Bachelor’s degree (MBA Preferred) in Accounting or Finance with progressive accounting experience in publicly traded companies
  • Experience with integrated systems including financial reporting, general ledger, purchasing, payables management (NetSuite ERP a plus)
  • Experience with assessing, designing and implementing internal controls over financial reporting
  • Ability to engage peers from across the organization and direct/indirect reports
  • Ability to work in a dynamic work environment
  • Biotech/Pharma experience
  • Strong team orientation and highly collaborative

To Apply:

Please click here to apply!

Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

 

 

Turnstone Biologics Inc. is the leading virus-based immunoncology biotechnology company developing novel oncolytic vaccine therapeutics for cancer patients. Our first-in-class platform technology attacks tumours using a two-pronged approach: targeted and robust tumour killing using an oncolytic virus, in combination with a cancer vaccine that generates long-lasting anti-tumour immune responses. Turnstone is building a world-class, high-performing team that embraces being a learning organization with a sense of urgency. Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Canada and New York, USA. For more information, please visit www.turnstonebio.com or email info@turnstonebio.com.

How do you know if you’re the right fit?

Imagine coming to work every day where over-communication, transparency, teaching, listening, asking, thinking, working hard, and having fun are normal – actually, expected? Imagine having a coach, mentor, peers, and partners where candid feedback, self-improvement, risk taking, failing, learning from that failing, and succeeding are what we call ‘another Thursday at Turnstone’? At Turnstone, the science drives decision making, and our drugs are designed with the patient in mind. Like the disease we’re fighting, our platform is complex, and transformative. If you’re a passionate person, and our science excites you – this opportunity may be for you.

If you are interested in being a part of a growing IT and business operations team, then this role may be for you! Your role will be to work directly with the CFO and manage the global Information Technology and Informatics function.  Lead the design, implementation and growth of our information architecture.  This individual will manage infrastructure and resources to meet organizational needs and will be responsible for working cross-functionally with all departments to identify long-term, scalable, practical solutions for research and operations as the organization grows.   He/she will be expected to establish close partnerships with colleagues from multiple disciplines to translate business needs into state-of-the-art informatics solutions.  You will have experience working with some or all the following, as they relate to the Director of IT duties:

Leadership

  • Provide strong leadership and business acumen, as well as data and analytical skills and relationship-building capabilities to inspire the organization around common goals, vision and values for IT and informatics
  • Define and implement data architecture and company-wide strategy for data storage, processing, analysis and mining
  • Serve as champion for global data management, governance, quality and vendor relationships across the company
  • Establish an architecture and a collection of integrated decision-support applications and databases, providing the company easy access to corporate data.
  • Grow the breadth and depth of department expertise to meet short and long-term corporate objectives

Information Technology

  • Oversee contingency planning and IT security and compliance by establishing controls and processes in support of data security, PHI, SOX and other relevant regulatory requirements
  • Manage vendors, consultants and overall budget for data management and IT
  • Lead the planning and estimation of IT & Informatics projects
  • Regularly and effectively communicate with key project stakeholders, keeping them advised of project progress and generally making IT activities transparent to stakeholders
  • Set strategy for IT infrastructure and software capabilities for current and future organizational needs
  • Maintain ongoing knowledge of industry trends and ability to utilize that knowledge to determine the most efficient ways to meet business needs
  • Communicate strategy to scientific personnel, operations and senior management to ensure alignment
  • Measures availability, performance, capacity, and utilization of IT and Informatics services
  • Detects, monitors, reports, manages, escalates and ultimately prevents service failures and/or degradations.
  • Takes ownership of security across the board and lead IT related compliance for the Company.
  • Collaborate with others to facilitate business needs definition, workflow design and integration of scientific processes and technology into effective IT solutions
  • Understanding and familiarity with Mac, Apple iOS preferred

Research Informatics

  • Work with R&D team to develop and implement computational biology strategy, goals and evolution of the team
  • Implement and maintain key research systems, including ELN, LIMS and Results Management
  • Grow and effectively maintain cloud-based computing environment
  • Develop and implement data integration and analytics strategy

What’s in it for you?

In this role, you will have the opportunity to develop your ability to think both strategically and drive fast-paced execution.  With our company size and growth we will give you plenty of opportunities for you to be an inspirational and collaborative co-functional leader.  Passionate about IT and Information and continuous learning?  We will have plenty of that for you!

We are in the early stages of building strategies, structures and process so this role will be busy and expanding. We also have opportunities for you to be mentor to other team members. You would have the opportunity to create something new and ‘WOW!’ all of us and grow right along with the company.

The details

This role is best suited for a some with the following:

  • Advanced degree in life sciences, plus 7-10 years of relevant experience working in Biotech
  • 5-7 years of experience managing and implementing informatics and IT solutions in a start-up, biotech environment
  • Ability to identify impediments to complex business and research issues and provide timely and cost-effective solutions
  • Solid scientific/ technical knowledge to be able to successfully ensure project scope and fit technology for applications, networking and information systems strategic roadmap and execution of all Informatics solutions and IT services
  • Experience with evaluating, implementing and managing scientific data management platforms, cloud computing (AWS), Document control/electronic lab notebook software, on-site storage solutions and IT vendor services
  • Prior experience and record of accomplishment leading cross functional teams and delivering on schedule in a start-up biotech environment
  • Prior experience in successfully implementing, utilizing and leveraging outsourcing strategies
  • Practical understanding of relational database design and development
  • Demonstrated understanding of the software development lifecycle
  • Ability to adapt to increasing scope and complexity of work brought on by growth/change and helps others manage through change
  • Strong written, oral and public speaking communication skills.

 To Apply:

Please click here to apply!

 Turnstone Biologics welcomes and encourages applications from people with disabilities. Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.

Notice to Recruiters: Turnstone Biologics values our recruiting partnerships, but to protect the interest of all parties, we do not accept unsolicited resumes from recruiters. All recruiting is managed through our human resources department.

Contact

Ottawa

787 Bank Street, 2nd Floor
Ottawa, Ontario K1S 3V5
(613) 421-8930

New York City

920 Broadway, 16th Floor
New York, New York 10010
(613) 421-8930

General

Please contact us with any questions
or comments.

Info@turnstonebio.com

Media

Please contact Pure Communications
for any media inquiries.

Turnstone@W2OGroup.com